Dmel008096.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila melanocephala
Gene Symbol
zfh1
Assembly
GCA_037043625.1
Location
JBAMBD010000597.1:1318612-1324302[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.7e-05 0.0018 18.6 1.0 1 23 152 174 152 174 0.97
2 15 0.00083 0.055 13.9 1.2 3 23 182 202 180 202 0.94
3 15 9e-05 0.006 16.9 0.1 1 23 356 378 356 378 0.98
4 15 0.0036 0.24 11.9 2.4 1 23 384 406 384 406 0.98
5 15 7.8e-05 0.0051 17.1 2.1 1 23 438 461 438 461 0.95
6 15 0.71 47 4.6 4.3 1 23 502 524 502 524 0.87
7 15 0.004 0.26 11.7 0.4 1 23 530 553 530 553 0.98
8 15 0.026 1.7 9.1 0.4 3 19 562 578 561 579 0.95
9 15 0.00016 0.01 16.2 5.6 1 23 588 610 588 610 0.97
10 15 0.041 2.7 8.6 1.2 2 23 616 637 615 637 0.96
11 15 9.2e-06 0.00061 20.0 1.0 1 23 646 668 646 668 0.98
12 15 0.00022 0.014 15.7 0.5 3 23 676 696 674 696 0.97
13 15 5.6e-05 0.0037 17.6 0.5 1 23 702 724 702 725 0.95
14 15 0.047 3.1 8.4 0.4 1 23 735 757 735 757 0.97
15 15 0.0005 0.033 14.6 0.8 1 23 1260 1282 1260 1282 0.98

Sequence Information

Coding Sequence
ATGAACAATCCGAACTATGGCGGCATCCAGTGGATACAGCAGGAAAACAGCGCCGTCGTCGACGACAGCGAATCAGAGATGACAGCAGCATATTTGGTCAACGCTGACGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTCATCTTTATGGCACGCGACGGCCAACTGAGCGAAATCATCGCCGCCAATGAGGCAaatggcggcagcagcacagTGCTAATCACGGAGAGCGACGGAAATAACGGTGTCGAGTACGCCGAGTCCTTTGACGATGATACCCAAGTCGTCACCGAGGAGATCATCACGGACGATTGGGTCCAGCATCAGGGTGCAGAGCGagTGGAAATTGCCGCTGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGCAGCAGAATGAGTATATGGCGATGCGTCCCTATCCCTGTGACTTTTGCAGTCGACGGTTTCGGAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGTCCCCATCTCTGCAAGCTGTGCGGGGCGCGTTTCTCGCGTCGCGCGGAGCTCATCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATCAAATTtgagccacaacagcagctgcaacaacagcagcagcgacaaattGATGATCATTTCTACGAGCAGGAATGGCCGCTGTAtcaggaacaggagcaggagcaggtcgaggagcagctggagcagatcgaggagcagcagcagttggaacagcaccagcagctaTTGCAACACTTGGTGGCACCACCAACCGCTGCCCGGGGACGCATCAGTCGCTTAAAGCTCAAGGAGGAGAGTTCGCAGTATATTGCGAATTGCGATCAATCACatgccaccaacaacaaccaactcCAGTCAACATCCAATAATgatgttgccactgctgctgctgctgctgatggggCACATGGGCAGGaacaggggcaggggcaggcaACGCTGCGTTTTCCCGTGCTCGACGAGAGCAAACCCTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAACTGCAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCATCGGCGGGCGAGGAGGATACGGCGAGCGAATCGGAAGCGGAACAGCTTTACGGCAATTACTACTGCGGCGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacagcaagcagctggctgcaacaacagctggcaacaacaacaacagtgtggcaactgcaacagcaacggatgcagctgcagctgcaactgatgTCGATGCTGATGATGCCAAAGATGCGCCACATTGTTGCCACACGTGCGGCAAGTCATTTCTCAGCGTACTCAAACTGCTCGCGCATACCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGCGTCAGTTTCTACGAGGAGCAGGCCATAAAGCGGCACCTGAACACGCGGCATCCGCATGAGCTGAAGCCCAATTCGTGTGTGCTGTGTGGCAAGGAGTGTCGGGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCACGGGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAACGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAGGTGTGCCACGAGGAGTTCCCAGATGGACGCACCTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCGCGCAGCTCGCAACAGATTCATGTGCGCATCCATACGGGTGAGAGGCCCTACGGCTGTCACTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGCAAACACGAACGCATCCACACGGGCGAGAAGCCCTATGCCTGCTCCGTCTGTCCGCGTGCCTTCAATCAGCGTGTCGTGTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGTGGCACGTACCATTGCACGGTCTGCTCCGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTacTGGTCCACGTAAATATAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCGCGCAGAGCACAAGGCTGGCGGGGGCGAaggcgaggaggaggaggagtatGGCAGCGACTTGGACTACTGCGATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAGCCGCagagccaccaccaccagccaCCAAAAAGGcgaaacgcaaacgcaaagcGCCAATTAAAACCGGCGATGAGCAAAGATTGTGGGATGAGAAATTCCTGCAGCAGGCGAGCAATGGGAACAGCGATGAGGCTTACAAGAGTTTCTTTCAAATGGACTCGCTGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCACGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAAAACTCAAAACAGGCAatcgcagcagcaaaagaaggGCAGGCAAATCTGGGGTAGGAGCAGCAGGTGGAACAGCAGGAGTAGTAGAAGCCGTTGCTGCTCCACGTCCCCGCATGATACACACGGCCAAGTCGCAGCAGACAACGTCAAGGAAATCCCGCACAAGGAGCTATGTCACACGCACCAGCACCaatgagcagctgcagcagcagcagacaggaGGAGGAGCAAGCCTCATCAAATCGCGCATTGTGGACGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCAAACAGGAGCAGgaacatcaacagcatcatcagcaacagcagcaccagcagcagcagcagcagcgagtccAACTACTCTTCGACGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCGAGCATTGTCCAAGATCTCGAGGAGATATTGCGTAGTCCCCCCAAGCATGAGCGAAACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTCATTAAGATCGAGCCAACGTCGCCGGATCTACGCGAAATGGTCGAgagccagcagccagccacaCTGCCCACATCCTCCTCCGCCGCCTGCTCAACGGCGGCACGCACTTTCCGCCACCTGCGACAGCTGACTGCCAAtcgttccagttccagttccattTCCACTGCCACTTCCGGTTCCAGTTCCAGTGCCGCTGCCAGCACGCGAGCCGCTGCCAAGCGCAATGCCAGCAAGCAGCTTGCCAAGAAATCCAAAGCCAATTCATCATCGTCTTATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcagccaGTGCCAATGGTTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCAGCGGACGCAGCCGATGCAGCTGCGaaggcagcagccagcaaaacgGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCAATTTTCCAGATCGCTCGCAGCTGCTGgaacacatgcacatacacatctaG
Protein Sequence
MNNPNYGGIQWIQQENSAVVDDSESEMTAAYLVNADANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNNGVEYAESFDDDTQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQQQQQRQIDDHFYEQEWPLYQEQEQEQVEEQLEQIEEQQQLEQHQQLLQHLVAPPTAARGRISRLKLKEESSQYIANCDQSHATNNNQLQSTSNNDVATAAAAADGAHGQEQGQGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNCSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNYYCGECGISFHRQDLLRRHSKQQHSKQLAATTAGNNNNSVATATATDAAAAATDVDADDAKDAPHCCHTCGKSFLSVLKLLAHTEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCHYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGGEGEEEEEYGSDLDYCDLDVENVDELLQEAAAEPPPPATKKAKRKRKAPIKTGDEQRLWDEKFLQQASNGNSDEAYKSFFQMDSLVVVNDQTLQPVDAGVATTKLQQAEIKEQKLKTGNRSSKRRAGKSGVGAAGGTAGVVEAVAAPRPRMIHTAKSQQTTSRKSRTRSYVTRTSTNEQLQQQQTGGGASLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHQQQQHQQQQQQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPATLPTSSSAACSTAARTFRHLRQLTANRSSSSSISTATSGSSSSAAASTRAAAKRNASKQLAKKSKANSSSSYLSYGVDSYNVGVAASANGSSDVSSGFFSISEVVSAADAADAAAKAAASKTERRTRCFECEMCSSNFPDRSQLLEHMHIHI