Ddif007596.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila differens
Gene Symbol
zfh1
Assembly
GCA_037043665.1
Location
JBAMAZ010000280.1:890185-896436[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.9e-05 0.0019 18.5 1.0 1 23 152 174 152 174 0.97
2 15 0.0016 0.11 13.0 1.4 3 23 182 202 180 202 0.94
3 15 9.7e-05 0.0063 16.9 0.1 1 23 381 403 381 403 0.98
4 15 0.00033 0.022 15.2 0.9 1 23 409 431 409 431 0.98
5 15 8.3e-05 0.0054 17.1 2.1 1 23 463 486 463 486 0.95
6 15 0.76 50 4.6 4.3 1 23 527 549 527 549 0.87
7 15 0.0043 0.28 11.7 0.4 1 23 555 578 555 578 0.98
8 15 0.028 1.8 9.1 0.4 3 19 587 603 586 604 0.95
9 15 0.00017 0.011 16.1 5.6 1 23 613 635 613 635 0.97
10 15 0.044 2.8 8.5 1.2 2 23 641 662 640 662 0.96
11 15 9.9e-06 0.00064 20.0 1.0 1 23 671 693 671 693 0.98
12 15 0.0011 0.073 13.5 0.1 3 23 701 721 699 721 0.97
13 15 6e-05 0.0039 17.5 0.5 1 23 727 749 727 750 0.95
14 15 0.051 3.3 8.3 0.4 1 23 760 782 760 782 0.97
15 15 0.00054 0.035 14.5 0.8 1 23 1287 1309 1287 1309 0.98

Sequence Information

Coding Sequence
ATGAACAATCCGAACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAATCAGAGATGACAGCAGCATATTTGGTCAACGCTGACGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAatcttatttttatggcacGCGACGGCCAACTGAGCGAAATCATCGCCGCCAATGAGGCAaatggcggcagcagcacagTGCTAATCACGGAGAGCGACGGAAATAACGGTGTCGAGTACGCCGAGTCCTTTGACGATGATACCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGTGCAGAGCGagTGGAAATTGCCGCTGAGCAAATCGCTGGCACCGGCAGCTCCCAGGAACTGTTGGACATGCAACAGAATGAGTATATGGCGATGCGTCCCTATCCCTGCGACTTTTGCAGTCGACGGTTTCGGAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGGCCCCATCTCTGCAAGCTGTGCGGGGCGCGTTTTTCGCGTCGCGCGGAGCTCCTCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATCAAATTtgagccacaacagcagctgcaacaacagcagcagcagcagcagcagcgacaaattGAGGATCATTTCTATGAGCAGGAATGGCCGCTGTatcaggaacaggaacaggagcaggagcaggtcgaggagcagctggagcagatcgaggagcagcagcagttggaacagcatcagcagctatTGCAACACTTGGTGGCACCACCAACCGCTGCCCGGGGACGCATCAGTCGCTTAAAGCTCAAGGAGGAGAGTTCGCAGTATATTGTGATTGCCTCCGATAAACAGGAggcggagacggagacggagttGCCTCAATACATGCATTGCGAGGCGAATTGCGACCAATCACatgccaccaacaacaaccaactcCAATCAACATCCAACAATgatgttgcaactgctgctgctgctgatgaggCACATGGGCAGGGGCATGGGCAGGCAACGCTGCGTTTTCCCGTGCTCGACGAGAGCAAACCCTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGGGTGGATTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAACTACAGTCTGCAGGAGCATCAGAAGACGCACCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCATCGGCGGGCGAGGAGGATACGGCGAGCGAATCGGAAGCGGAACAGCTTTACGGCAATTACTACTGCGGCGAATGCGGCATCTCCTTTCACCGGCAGGATTTGCTACGGCgccacagcaaacagcagcacagcaagcagctggctgcaacaacagctggcaacaacaacaacagtgtggcaactgcaacagcaacggatgcagctgcagctgcaactgatgCCGAAGCTGATGATGCCAAAGATGCGCCACATTGTTGCCACACGTGCGGCAAATCATTTCTCAGCGTACTCAAACTGCTCGCGCATACCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGCGTCAGTTTCTACGAGGAGCAGGCCATAAAGCGGCACCTGAATACGCGGCATCCGCATGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcaAGGAGTGTCGAGATCGGAAGGCGCTGATCAAACATGCCTGGGATCATTCACGGGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAACGACACATGGCGTCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCAGATGGACGCACCTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCGCGCAGCTCGCAACAGATTCATGTGCGCATCCATACGGGTGAGAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGCAAACACGAGCGCATCCACACGGGCGAGAAGCCCTATGCCTGCTCCGTCTGTCCGCGTGCCTTCAATCAGCGTGTCGTGTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGCGGCACGTATCATTGCACGGTCTGCTCCGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTACTGGTCCACGTAAATATAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCGCGCAGAGCACAAGGCTGGCGGTGGCGAAGGCGAGGAGGAGGATTATGGCAGCGACTTGGACTACTGCGATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAGCCGCagagccaccaccaccagccaCAAAAAAAGCGAAACGCAAACGCAAGGCGCCAATTAAAACCGGCGATGAGCAAAGATTGTGGGATGAGAAATTCCTGCAGCAGGCGAGCAATGGGAACAGCGATGAGGCCTACAAGAGTTTCTTTCAAATGGACTCGCTGGTCGTGGTCAATGACCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCACGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAAAACTCAAAACAGGCAatcgcagcagcaaaagaaggGCAGGCAAATCTGggggaggagcagcaggaggaacAGCAGGAGTAGTAGAAGCTGTTGCTCCTCCACGTCCCCGCATGATACACACGGCCAAGTCGCAGCAGACAACGTCAAGGAAGTCCCGCACAAGGAGTTATGTCACACGCACCAGCACAaatgagcagctgcagcagccaggaGGAGGAGCAAGCCTCATCAAATCGCGCATTGTGGATGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCAAACAGGAGCAGgaacatcaacagcatcatcagcaacagcagcaccagcaccagcagcagcaccagcgaGTCCAACTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCGAGCATTGTCCAAGATCTCGAGGAGATATTGCGTAGTCCCCCCAAGCATGAGCGAAACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTCATCAAGATCGAGCCAACGTCGCCGGATCTACGCGAAATGGTCGAgagccagcagccagccacaCTGCCCACATCCTCCTCCGCCGCCTGCTCAACGGCGGCACGCACTTCCCGCCACCTGCGACAGCTAACTGCCAATGGTTCCAGTTCCATTTCCACTGCCACTTCCAGTTCCAGTGCCGCTGGCAGCACGCGAGCCGCTGCCAAGCGCAATGCCAGCAAGCAGCTTGCCAAGAAATCCACTTCCAATAGCAGCAAAGCCAACTCATCATCGTCTTATCTCAGCTATGGCGTCGACTCCTATAATGTGGGCGTGTCAGCCAGTGCCAATGGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCAGCGGATGCAGCCGATGCAGCTGCgaaggcggcggcggcagcagccagcaaaacgGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCAATTTTCCAGATCGCTCACAGCTGCTGgaacacatgcacatacacatctAG
Protein Sequence
MNNPNYGGIQWIQQESSAVVDDSESEMTAAYLVNADANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNNGVEYAESFDDDTQVVTEEIITDDWVQHQGAERVEIAAEQIAGTGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELLSHFKAHAEAQVAADEEAAAAAIKFEPQQQLQQQQQQQQQRQIEDHFYEQEWPLYQEQEQEQEQVEEQLEQIEEQQQLEQHQQLLQHLVAPPTAARGRISRLKLKEESSQYIVIASDKQEAETETELPQYMHCEANCDQSHATNNNQLQSTSNNDVATAAAADEAHGQGHGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNYYCGECGISFHRQDLLRRHSKQQHSKQLAATTAGNNNNSVATATATDAAAAATDAEADDAKDAPHCCHTCGKSFLSVLKLLAHTEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGGEGEEEDYGSDLDYCDLDVENVDELLQEAAAEPPPPATKKAKRKRKAPIKTGDEQRLWDEKFLQQASNGNSDEAYKSFFQMDSLVVVNDQTLQPVDAGVATTKLQQAEIKEQKLKTGNRSSKRRAGKSGGGAAGGTAGVVEAVAPPRPRMIHTAKSQQTTSRKSRTRSYVTRTSTNEQLQQPGGGASLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHQQQQHQHQQQHQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPATLPTSSSAACSTAARTSRHLRQLTANGSSSISTATSSSSAAGSTRAAAKRNASKQLAKKSTSNSSKANSSSSYLSYGVDSYNVGVSASANGSSDVSSGFFSISEVVSAADAADAAAKAAAAAASKTERRTRCFECEMCSSNFPDRSQLLEHMHIHI