Basic Information

Insect: Drosophila conformis
Gene Symbol: zfh1
Assembly: GCA_035041375.1
Location: JAWNLE010001018.1:224333-229047[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.3e-05 0.0015 18.9 1.3 1 23 152 174 152 174 0.97

2 15 0.00094 0.061 13.8 1.2 3 23 182 202 180 202 0.94

3 15 0.0001 0.0067 16.9 0.1 1 23 379 401 379 401 0.98

4 15 0.00035 0.023 15.2 0.9 1 23 407 429 407 429 0.98

5 15 0.00013 0.0082 16.6 2.3 1 23 461 484 461 484 0.94

6 15 0.026 1.7 9.3 1.5 1 23 532 554 532 554 0.93

7 15 0.0028 0.18 12.4 0.4 1 23 560 583 560 583 0.98

8 15 0.03 2 9.1 0.4 3 19 592 608 591 609 0.95

9 15 0.00018 0.012 16.1 5.6 1 23 618 640 618 640 0.97

10 15 0.046 3 8.5 1.2 2 23 646 667 645 667 0.96

11 15 1e-05 0.00068 20.0 1.0 1 23 676 698 676 698 0.98

12 15 0.0012 0.077 13.5 0.1 3 23 706 726 704 726 0.97

13 15 6.3e-05 0.0041 17.5 0.5 1 23 732 754 732 755 0.95

14 15 0.054 3.5 8.3 0.4 1 23 765 787 765 787 0.97

15 15 0.0039 0.25 11.9 0.5 1 23 1295 1317 1295 1317 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.3e-05	0.0015	18.9	1.3	1	23	152	174	152	174	0.97
2	15	0.00094	0.061	13.8	1.2	3	23	182	202	180	202	0.94
3	15	0.0001	0.0067	16.9	0.1	1	23	379	401	379	401	0.98
4	15	0.00035	0.023	15.2	0.9	1	23	407	429	407	429	0.98
5	15	0.00013	0.0082	16.6	2.3	1	23	461	484	461	484	0.94
6	15	0.026	1.7	9.3	1.5	1	23	532	554	532	554	0.93
7	15	0.0028	0.18	12.4	0.4	1	23	560	583	560	583	0.98
8	15	0.03	2	9.1	0.4	3	19	592	608	591	609	0.95
9	15	0.00018	0.012	16.1	5.6	1	23	618	640	618	640	0.97
10	15	0.046	3	8.5	1.2	2	23	646	667	645	667	0.96
11	15	1e-05	0.00068	20.0	1.0	1	23	676	698	676	698	0.98
12	15	0.0012	0.077	13.5	0.1	3	23	706	726	704	726	0.97
13	15	6.3e-05	0.0041	17.5	0.5	1	23	732	754	732	755	0.95
14	15	0.054	3.5	8.3	0.4	1	23	765	787	765	787	0.97
15	15	0.0039	0.25	11.9	0.5	1	23	1295	1317	1295	1317	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAAGCAGAGATGACAGCAGCCTATTTGGTCAACGCTGCCGCCAATGGAAGCATTTCCAACGATGACGAGCTCGATCATATTGCAGCCGAGAATCTCATCTTTATGGCACGCGACCGCCAACTGAGCGAAATCATCGCCGCAACTGAGGCAAATGGCGGCAGCACCACAGTGCTAATTGCGGAGAGAGACGGAAATAACGGAGTGGAATACGCCGAGTCCTTTGACGATGATGCCCAAGTCGTCACCGAAGAGATCATCACGGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgTGGAAATTGCAGCAGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGcaacagaatatatatatttcgatgcGTCCATATCCCTGTGACTTTTGCAGTCGACGCTTTCGCAAGAAGGCCAGCCTCAACAATCACATGCAGGCGCATCAGAATGATCGGCCCCATCTCTGCAAGCTGTGCGGGGCGCGTTTCTCGCGACGTGCGGAGCTCATCAGTCACTTCAAGGCTCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATTAAATTtgagccacaacagcagctgcaatcgctgcaacagcagcagcagcagcagcgacaaattGATGATCATTTCTATGAGCAGGAATGGCCGCTGTATCAGGAACATGAACAGGAGCAGatcgaggagcagcagctgcagcagatcgaggagcagcagcagcagcagctggagcagttTCAGCAGCGCTTGCAACATTCGGTTGCACCACCAACCGCTGCTCGTGGACGTATCAGTCGATTGAAACTCAAGGAGGAGAGCTCCCAATATATTGTGATTGCCTCCGATAAACCGGAGGCGGAGTTGCCTCAATACGTGCATTGCGAGGCGAATGGCGATCAATCACttgccaccaccaacaacagccaagTCCAATCAACATCATCCAATgatgttgccactgctgctgctgctgctgctgctgatggggCAGAGGGGCAGGCAACGCTGCGCTTTCCCGTGCTCGACGAGAGCAAACCGTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCTTTTGAGTGCAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAATTCGGAATATGATCCCGCATCGGCGGGCGAGGAGGATACGGCGAGTGAATCGGAAGCGGAGCAGCTTTACGGTAATTTCTACTGTGGGGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacagcaagcagctggctgcaacaacagctggtggcaacaacaacaacaacaacagtgtggcaactgcaacagcaacggaTGCAATGGGTGCCGCagatgcaactgcaactgatgccgatgctgatgaTTCCAAAGATGCGACACATTGTTGCCGCACGTGCGGCAAATCATTTCCCAGCGTACTCAAACTGCTCGCCCATGCCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGAATCAGCTTCTACGAGGAGCAGGCGATAAAGCGGCACCTGAACACGCGGCATCCGCACGAGCTGAAGCCCAActcgtgtgtgttgtgtggcaAGGAGTGTCGCGATCGAAAGGCGCTGATCAAACATGCGTGGGATCATTCGCGAGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAGCGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCCGATGGACGCACTTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTATTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCACGCAGCTCGCAGCAGATTCATGTGCGCATCCACACGGGTGAAAGGCCTTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGACGGCGGCACTCTCCGCAAACACGAACGCATCCATACGGGCGAGAAGCCCTATGCGTGCTCCGTCTGCCCGCGTGCCTTCAATCAGCGTGTCGTCTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGTGGCACGTATCACTGCACGGTGTGCTCGGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAGCAGCGACAGCCAATTACTGGCCCACGTAAATACAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCACGCCGAGCACAAGGCTGGCGGCGGCGATGGCGAGGCTGGCGAGGAGGAGGATTATGCCAGCGACTTGGACTACTGCCATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAACCGCAGAGCCACCATCACCCGCCAAAAAAGCGAAACGCAAACGCAAAGCGCCAATTAAACCCGGTGATGAGCAAAGATTGTGGGATGAGAAGTTCCCGCAGCAGGCGAGCAATGGGAATAGCGATGCGGCCTACAAGAGTATCTTCCAGATGGACTCAGTGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCTCGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAACACCGCAGACAGGCAATCGCAGTAGCAAGAGAAGGGCAGGTAAAGCTgggggaggaggagcaggcgcaccaggaggaggaggagctgctgctactgctgctccaCGTCCCCGGATGATACACACGGCCAAGTCGCAGCAGACACCGGCAAGGAAATCCCGCACAAGGAGTTATGTCACACGCACCAGCAccaatgagcagcagcagggggAAGGAGCAAGTGGAGGAAGCCTCATCAAATCCCGGATTGTAGATGACTACGAGATCATCTCCCCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCaaacaggagcaggaacatcaacagcatcatcatcatcagcatcagcatcatcagcagcagcaccagagAGTCCAGTTGCTCTTCGATGACAGCCACCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCCAGCATTGTCCAAGATCTCGAAGAGATTTTGCGTAGTCCCCCGAAGCATGAGCGGAACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCggcgaggaggaggaacagCATCTCATCAAGATCGAGCCCACGTCGCCGGATCTCCGCGAAATGGTCGAGagccagcagccagcggcACTGCCCACATCTTCCTCCGCCTGCTCAACGGCAGCACGTACTTCCCGCCACCTGCGACAACTGACTGCCAATGGTTCCAGTTCCATTTCCACTGCCACATCCAGTTCCAGTGGCGCTCCAAGTACGCGAGCCGCTTCCAAGCGCAATGCCAGCAAACAGCTTTCCAAGAAATCCActtccaacagcaacaaaggcaacgCTTCATCGTCTTATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcaaccaGTGCCAATAGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCGGCGGATGCAGCCgatgcagctgcaacggcggcggcggcagcagccagcagaacGGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCTATTTCCCAGATCGCGCCCAGCTGCTGGAACACATGCACGTGCACATCTAG
Protein Sequence: MNNPDYGGIQWIQQESSAVVDDSEAEMTAAYLVNAAANGSISNDDELDHIAAENLIFMARDRQLSEIIAATEANGGSTTVLIAERDGNNGVEYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNIYISMRPYPCDFCSRRFRKKASLNNHMQAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQSLQQQQQQQRQIDDHFYEQEWPLYQEHEQEQIEEQQLQQIEEQQQQQLEQFQQRLQHSVAPPTAARGRISRLKLKEESSQYIVIASDKPEAELPQYVHCEANGDQSLATTNNSQVQSTSSNDVATAAAAAAADGAEGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNFYCGECGISFHRQDLLRRHSKQQHSKQLAATTAGGNNNNNNSVATATATDAMGAADATATDADADDSKDATHCCRTCGKSFPSVLKLLAHAEIHKRFPPFKCVLCGISFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMHAEHKAGGGDGEAGEEEDYASDLDYCHLDVENVDELLQEATAEPPSPAKKAKRKRKAPIKPGDEQRLWDEKFPQQASNGNSDAAYKSIFQMDSVVVVNDQTLQPVDAGVASTKLQQAEIKEQTPQTGNRSSKRRAGKAGGGGAGAPGGGGAAATAAPRPRMIHTAKSQQTPARKSRTRSYVTRTSTNEQQQGEGASGGSLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHHHQHQHHQQQHQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPAALPTSSSACSTAARTSRHLRQLTANGSSSISTATSSSSGAPSTRAASKRNASKQLSKKSTSNSNKGNASSSYLSYGVDSYNVGVATSANSSSDVSSGFFSISEVVSAADAADAAATAAAAAASRTERRTRCFECEMCSSYFPDRAQLLEHMHVHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -