Basic Information

Insect: Drosophila kokeensis
Gene Symbol: zfh1
Assembly: GCA_035042145.1
Location: JAWNLT010000346.1:857865-862816[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.9e-05 0.0019 18.5 1.0 1 23 152 174 152 174 0.97

2 15 0.0009 0.058 13.9 1.2 3 23 182 202 180 202 0.94

3 15 9.7e-05 0.0063 16.9 0.1 1 23 364 386 364 386 0.98

4 15 0.00034 0.022 15.2 0.9 1 23 392 414 392 414 0.98

5 15 9.8e-05 0.0063 16.9 3.0 1 23 446 469 446 469 0.94

6 15 0.016 1 9.9 2.3 1 23 515 537 515 537 0.94

7 15 0.0043 0.28 11.7 0.4 1 23 543 566 543 566 0.98

8 15 0.028 1.8 9.1 0.4 3 19 575 591 574 592 0.95

9 15 0.00017 0.011 16.1 5.6 1 23 601 623 601 623 0.97

10 15 0.044 2.8 8.5 1.2 2 23 629 650 628 650 0.96

11 15 9.9e-06 0.00064 20.0 1.0 1 23 659 681 659 681 0.98

12 15 0.0011 0.072 13.5 0.1 3 23 689 709 687 709 0.97

13 15 6e-05 0.0039 17.5 0.5 1 23 715 737 715 738 0.95

14 15 0.051 3.3 8.3 0.4 1 23 748 770 748 770 0.97

15 15 0.0039 0.25 11.8 0.5 1 23 1278 1300 1278 1300 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.9e-05	0.0019	18.5	1.0	1	23	152	174	152	174	0.97
2	15	0.0009	0.058	13.9	1.2	3	23	182	202	180	202	0.94
3	15	9.7e-05	0.0063	16.9	0.1	1	23	364	386	364	386	0.98
4	15	0.00034	0.022	15.2	0.9	1	23	392	414	392	414	0.98
5	15	9.8e-05	0.0063	16.9	3.0	1	23	446	469	446	469	0.94
6	15	0.016	1	9.9	2.3	1	23	515	537	515	537	0.94
7	15	0.0043	0.28	11.7	0.4	1	23	543	566	543	566	0.98
8	15	0.028	1.8	9.1	0.4	3	19	575	591	574	592	0.95
9	15	0.00017	0.011	16.1	5.6	1	23	601	623	601	623	0.97
10	15	0.044	2.8	8.5	1.2	2	23	629	650	628	650	0.96
11	15	9.9e-06	0.00064	20.0	1.0	1	23	659	681	659	681	0.98
12	15	0.0011	0.072	13.5	0.1	3	23	689	709	687	709	0.97
13	15	6e-05	0.0039	17.5	0.5	1	23	715	737	715	738	0.95
14	15	0.051	3.3	8.3	0.4	1	23	748	770	748	770	0.97
15	15	0.0039	0.25	11.8	0.5	1	23	1278	1300	1278	1300	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAAACAGAGATGACAGCAGCCTATTTGGTCAACGCTGCAGCCAATGGAAGCATTTCCAACGATGACGAGCTCGACCATATAGCAGCGGAGAATCTCATCTTTATGGCGCGCGACCGCCAACTGAGCGAAATCATCGCCGCAAATGAGGCAAATGGCGGCAGCACCACATTGCTAATCACGGAGAGAGACGGAAATAACGGAGTGGAATACGCCGAGTCCTTTGACGATGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgTGGAAATTGCAGCAGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGCAACAGAATGAATATATGGCGATGCGTCCATATCCCTGTGACTTTTGCAGTCGACGCTTTCGCAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGTCCCCATCTCTGCAAACTGTGCGGGGCGCGTTTCTCGCGACGTGCGGAGCTCATCAGTCACTTCAAGGCTCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATTAAATTtgagccacaacagcagctgcaaccgctgcaacagcagcagcagcagcagcgacaaattGATGATCATTTCTATGAGCAGGAATGGCCGCTGCTCGatgagcagctggagcagatcgaggagcagcagcagcagcagctggagcagcttcACCAGCGGTTGCAACATTCGGTTGAACCACCAACCGCTGCTCGTGGACGCACCAGTCGATTGAAACTCAAGGAGGAGAGCTCCCAATATATTGTGATTGCCTCCGATAAACAGGAGGCGGAGTTGCCTCAATACATGCATTGCGAGGCGAATGGCGATCAATCACttgccaccaacaacagccaagTTCAATCAACATCATCCAATgatgttgcaactgctgctgatggggCAGAGGGGCAGGGAACGCAGCGCTTTCCCGTGCTCGACGAGAGCAAACCGTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCTTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAATTCGGAATATGATCCCGCATCGGCGGGCGAGGAGGATACGGCGAGTGAATCGGAAGCGGAACAGCTTTACGGTAATTTCTACTGCAGCGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacagcaagcagctggctgcaacaacagctggtggcaaaaacaacaacagtgtggcaactgcaacagcaacggaTGCAATGGGTGCTGcagatgcaactgcaactgatgccgatgctgatgaTTCCAAAGATGCGACACATTGTTGCCGCACGTGCGGCAAATCATTTCCCAGCGTACTCAAACTGTTCGCCCATGTCGAGATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGAGTCAGCTTCTACGAGGAGCAGGCGATAAAGCGGCACCTGAACACGCGGCATCCGCACGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcaAGGAGTGTCGCGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCGCGAGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAGCGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCCGATGGACGCACTTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTCTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCACGCAGCTCGCAACAGATTCATGTGCGCATCCACACGGGTGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGACGGCGGCACTCTCCGCAAACACGAACGCATCCATACGGGCGAGAAGCCCTATGCGTGCTCCGTCTGCCCGCGTGCCTTCAATCAGCGCGTCGTCTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGTGGCACGTACCATTGCACGGTGTGCTCGGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTACTGGGCCACGTAAATACAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCGCGTCGAGCAGAGGGCTGGCGGCGGGGATGGCGAGGCTGCCGAGGAGGAGGATTATGCCAGCGACTTGGACTACTGCCATCTGGATGTGGAGAATGTGGACGAACTGCTGCAGGAGGCAACGTCAGAGCCACCATCACCCACCAAAAAAGCGaaacgcaaacgcaaagcGCCAATTAAAACCGGTGATGAGCAAAGATTGCGGGATGAGAAATTCCCGCAGCAGACGAGCAACGGGAATAGCGATGAGGCCTACAAGAGTTTCTTCCAGATGGACTCAATGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCTCGACCAAGTTGCACCAGGCGGAGATTAAGGAGCAGACACTGAAGACAGGCAATCGCAGTAGCAAAAGAAGGGCAGGTAAAGCTgggggaggaggagcaggcgcagcaggaggaggagctgctgctactgctgctccacGTCCCCGGATGATACACACGGCCAAGTCGCAGCAGGCAACGGCAAGGAAATCCCGCACAAGGAGTTATGTTACACGCACCAGCAccaatgagcagcagcaggggggAGGAGCAAGTGGGGGAAGCCTCATCAAATCCCGGATTGTAGATGACTACGAGATCATCTCCCCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCaaacaggagcaggaacatcaactgcatcatcatcatcatcagcatcagcatcatcagcagcagcagcagagagtcCAACTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCCAGCATTGTCCAAGATCTCGAAGAGATTTTGCGTAGTCCTCCGAAGCATGAGCGGAACGATCGACGGCTGCGCTTCACAAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTCATCAAGATCGAGCCCACGTCGCCGGATCTCCGCGAAATGGTCGAGACCCAGCAGCCAGCGGCACTGCCCACATCTTCCTCCGCCTGCTCAACGGCAGCACGCACTTCCCGCCACCTGCGACAACTGACTGCCAATGGTTCCAGTTCCATTTCCACTGCCACATCCAGTTCCAGTGGCGCTCCAAGTACGCGAGCCGCTTCCAAGCGCAATGCCAGCAAACAGCTTTCCAAAAAATCCActtccaacagcaacaaaggcaacGCATCATCGTCTTATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcaaccaGTGCCAATAGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTTGTCTCGGCGGCGGATGCAGCCGATGCAGCTGCgaaggcggcggcggcagcagccagcaaaacgGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGTTCGTCCTATTTCCCAGATCGCGCTCAGCTGCTGgaacacatgcacatacacatctAA
Protein Sequence: MNNPDYGGIQWIQQESSAVVDDSETEMTAAYLVNAAANGSISNDDELDHIAAENLIFMARDRQLSEIIAANEANGGSTTLLITERDGNNGVEYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQPLQQQQQQQRQIDDHFYEQEWPLLDEQLEQIEEQQQQQLEQLHQRLQHSVEPPTAARGRTSRLKLKEESSQYIVIASDKQEAELPQYMHCEANGDQSLATNNSQVQSTSSNDVATAADGAEGQGTQRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNFYCSECGISFHRQDLLRRHSKQQHSKQLAATTAGGKNNNSVATATATDAMGAADATATDADADDSKDATHCCRTCGKSFPSVLKLFAHVEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRVEQRAGGGDGEAAEEEDYASDLDYCHLDVENVDELLQEATSEPPSPTKKAKRKRKAPIKTGDEQRLRDEKFPQQTSNGNSDEAYKSFFQMDSMVVVNDQTLQPVDAGVASTKLHQAEIKEQTLKTGNRSSKRRAGKAGGGGAGAAGGGAAATAAPRPRMIHTAKSQQATARKSRTRSYVTRTSTNEQQQGGGASGGSLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQLHHHHHQHQHHQQQQQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVETQQPAALPTSSSACSTAARTSRHLRQLTANGSSSISTATSSSSGAPSTRAASKRNASKQLSKKSTSNSNKGNASSSYLSYGVDSYNVGVATSANSSSDVSSGFFSISEVVSAADAADAAAKAAAAAASKTERRTRCFECEMCSSYFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -