Basic Information

Insect: Drosophila cracens
Gene Symbol: zfh1
Assembly: GCA_035042505.1
Location: JAWNLF010000162.1:882036-886806[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.8e-05 0.0019 18.5 1.0 1 23 152 174 152 174 0.97

2 15 0.00087 0.059 13.9 1.2 3 23 182 202 180 202 0.94

3 15 9.5e-05 0.0064 16.9 0.1 1 23 364 386 364 386 0.98

4 15 0.00033 0.022 15.2 0.9 1 23 392 414 392 414 0.98

5 15 0.00012 0.0078 16.6 2.3 1 23 446 469 446 469 0.94

6 15 0.011 0.77 10.3 3.0 1 23 514 536 514 536 0.94

7 15 0.0042 0.28 11.7 0.4 1 23 542 565 542 565 0.98

8 15 0.028 1.9 9.1 0.4 3 19 574 590 573 591 0.95

9 15 0.00016 0.011 16.1 5.6 1 23 600 622 600 622 0.97

10 15 0.043 2.9 8.5 1.2 2 23 628 649 627 649 0.96

11 15 9.6e-06 0.00065 20.0 1.0 1 23 658 680 658 680 0.98

12 15 0.0011 0.073 13.5 0.1 3 23 688 708 686 708 0.97

13 15 5.8e-05 0.0039 17.5 0.5 1 23 714 736 714 737 0.95

14 15 0.049 3.3 8.3 0.4 1 23 747 769 747 769 0.97

15 15 0.0038 0.26 11.8 0.5 1 23 1279 1301 1279 1301 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.8e-05	0.0019	18.5	1.0	1	23	152	174	152	174	0.97
2	15	0.00087	0.059	13.9	1.2	3	23	182	202	180	202	0.94
3	15	9.5e-05	0.0064	16.9	0.1	1	23	364	386	364	386	0.98
4	15	0.00033	0.022	15.2	0.9	1	23	392	414	392	414	0.98
5	15	0.00012	0.0078	16.6	2.3	1	23	446	469	446	469	0.94
6	15	0.011	0.77	10.3	3.0	1	23	514	536	514	536	0.94
7	15	0.0042	0.28	11.7	0.4	1	23	542	565	542	565	0.98
8	15	0.028	1.9	9.1	0.4	3	19	574	590	573	591	0.95
9	15	0.00016	0.011	16.1	5.6	1	23	600	622	600	622	0.97
10	15	0.043	2.9	8.5	1.2	2	23	628	649	627	649	0.96
11	15	9.6e-06	0.00065	20.0	1.0	1	23	658	680	658	680	0.98
12	15	0.0011	0.073	13.5	0.1	3	23	688	708	686	708	0.97
13	15	5.8e-05	0.0039	17.5	0.5	1	23	714	736	714	737	0.95
14	15	0.049	3.3	8.3	0.4	1	23	747	769	747	769	0.97
15	15	0.0038	0.26	11.8	0.5	1	23	1279	1301	1279	1301	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAAAGAGAGATGACAGCAGCCTATTTGGTCAACGCTGCCGCCAATGGAAGCATTTCCAACGATGACGAGCTCGACCATATAGCAGCCGAGAATCTCATCTTTATGGCACGCGATCGCCAACTGAGCGAAATTATCGCCGCAAATGAGGCAAATGGCGGCAGCACCACAGTGCTAATAGCGGAGAGAGACGAAAATAACGGAGTGGAATACGCCGAGTCCTTTGACGATGATGCCCAAGTCGTCACAGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgTGGAAATTGCAGCAGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGCAACAGAATGAATATATGGCGATGCGTCCATATCCCTGTGACTTTTGCAGTCGACGCTTTCGCAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGTCCCCATCTCTGCAAACTGTGCGGGGCGCGTTTCTCGCGACGTGCGGAGCTCATCAGTCACTTCAAGGCTCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATTAAATTtgagccacaacagcagctgcaaccgctgcaacagcagcagcagcgacaaattGATGATCATTTCTATGAGCAGGAATGGCCGCTGGTCGAGGAGCAGCTGTCGCAGatcgaggagcagcagcagcagcagctggagcagcttcAGCAGCGGTTGCAACATTCGGTTGTACCACCAACCGCTGCTCGTGGACGTATCAGTCGATTGAAACTCAAGGAGGAGAGCTCCCAATATATTGTGATTGCCTCCGATAAACCGGAGGCGGAGTTGCCTCAATACATGCATTGCGAGGCGAATGGCGATCAATCACttgccaccaacaacagccaagTCCAATCAACATCATCCAATGATgtagcaactgctgctgctgctgatggggCAGAGGGGCAGGCAACGCTGCGCTTTCCCGTGCTCGACGAGAGCAAACCGTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCTTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAATTCGGAATATGATCCCGCATCGGCGGGCGAGGAGGAAACGGCGAGTGAATCGGAAGCGGAACAGCTTTACGGTAATTTCTACTGCGGCGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacaagcagctggctgcaacaacagctggtggcaacaacaacaacagtgtggcaactgcaacagcaacggaTGCAATGGGTGCTGCagatgcaactgcaactgatgccgatgctgatgaTTCCAAAGATGCGACACATTGTTGCCACACGTGCGGCAAATCATTTCCCAGCGTACTCAAACTGCTCGCCCATGCCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGAGTCAGCTTCTACGAGGAGCAGGCGATAAAGCGGCACCTGAACACGCGGCATCCGCACGAGCTGAAGCCCAATTCGTGTGTGCTGTGTGGCAAGGAGTGTCGCGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCGCGAGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAGCGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCCGATGGACGCACTTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTCTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCACGCAGCTCGCAACAGATTCATGTGCGCATCCACACGGGTGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGACGGCGGCACTCTCCGCAAACACGAACGCATCCATACGGGCGAGAAGCCCTATGCGTGCTCCGTCTGCCCGCGTGCCTTCAATCAGCGTGTCGTCTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCGCGTGGCACGTATCATTGCACGGTCTGCTCGGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGCGATACGAACACAGCCAAACAGCGACAGCCAATTaCTGGCCCACGTAAATACAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCGCGCCGAGCACAAGGCTGGCGGTGGGGATGGCGAGGCTGGCGAGGAGGAGGATTATGCCAGCGACTTGGACTACTGCCATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAACCGCAGAGCCACCATCACCCACCAAAAAAGCGAAACGCAAACGCAAAGCGCCAATTAAAACCGGTGATGAGCAAAGATTGTGGGATGAGAAATTCCCGCAGCAGGCGAGCAATGGGAATAGCGATGAGGCCTACAAGAGTTTCTTCCAGATGGACTCAATGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCTCGACCAAGTTGCACCAGGCGGAGATTAAGGAGCAAACGCTGAAGACAGGCAATCGCAGTAGCAAAAGAAGGGCAGGTAAAGCTGGGGGAGGACGAGCAGGcgcagcaggaggaggaggagctgctgctactgctgctccaCGTCCCCGGATGATACATACGGCCAAGTCGCAGCAGACAACGGCAAGGAAATCCCGCACAAGGAGTTATGTCACACGCACCAGCAccaatgagcagcagcaaggggGAGGAGCAAGTGGGGGAAGCCTCATCAAATCCCGGATTGTGGATGACTACGAGATCATCTCCCCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCaaacaggagcaggaacatcaactgcatcatcatcatcatcatcagcatcagcatcatcagcagcagcagcagagagtcCAACTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCCAGCATTGTCCAAGATCTCGAAGAGATTTTGCGTAGTCCCCCGAAGCATGAGCGGAACGATCGACGGCTGCGCTTCACAAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTCATCAAGATCGAGCCCACGTCGCCGGATCTCCGCGAAATGGTCGAGACCCAGCAGCCAGCGGCACTGCCCACATCTTCCTCCGCCTGCTCAACGGCAGCACGCACTTCCCGCCACCTGCGACAACTGACTGCCAATGGTTCCAGTTCCATTTCCACTGCCACATCCAGTTCCAGTGGCCCTCCAAGTACGCGAGCCGCTTCCAAGCGCATTGCCAGCAAACAGCTTTCCAAGAAATCCActtccaacagcaacaaaggcaGCGCATCATCGTCTTATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcaaccaGTGCCAATAGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCGGCGGATGCAGCCGATGCAGCTGCgaaggcggcggcggcagcagccagcaaaacGGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCTATTTCCCAGATCGCGCCCAGCTGCTGgaacacatgcacatacacatctAA
Protein Sequence: MNNPDYGGIQWIQQESSAVVDDSEREMTAAYLVNAAANGSISNDDELDHIAAENLIFMARDRQLSEIIAANEANGGSTTVLIAERDENNGVEYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQPLQQQQQRQIDDHFYEQEWPLVEEQLSQIEEQQQQQLEQLQQRLQHSVVPPTAARGRISRLKLKEESSQYIVIASDKPEAELPQYMHCEANGDQSLATNNSQVQSTSSNDVATAAAADGAEGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEETASESEAEQLYGNFYCGECGISFHRQDLLRRHSKQQHKQLAATTAGGNNNNSVATATATDAMGAADATATDADADDSKDATHCCHTCGKSFPSVLKLLAHAEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGGDGEAGEEEDYASDLDYCHLDVENVDELLQEATAEPPSPTKKAKRKRKAPIKTGDEQRLWDEKFPQQASNGNSDEAYKSFFQMDSMVVVNDQTLQPVDAGVASTKLHQAEIKEQTLKTGNRSSKRRAGKAGGGRAGAAGGGGAAATAAPRPRMIHTAKSQQTTARKSRTRSYVTRTSTNEQQQGGGASGGSLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQLHHHHHHQHQHHQQQQQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVETQQPAALPTSSSACSTAARTSRHLRQLTANGSSSISTATSSSSGPPSTRAASKRIASKQLSKKSTSNSNKGSASSSYLSYGVDSYNVGVATSANSSSDVSSGFFSISEVVSAADAADAAAKAAAAAASKTERRTRCFECEMCSSYFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -