Basic Information

Insect: Drosophila cyrtoloma
Gene Symbol: zfh1
Assembly: GCA_035042485.1
Location: JAWNLH010001068.1:93386-99029[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.8e-05 0.0018 18.5 1.0 1 23 152 174 152 174 0.97

2 15 0.00086 0.056 13.8 1.2 3 23 182 202 180 202 0.94

3 15 9.4e-05 0.0061 16.9 0.1 1 23 378 400 378 400 0.98

4 15 0.0037 0.24 11.9 2.4 1 23 406 428 406 428 0.98

5 15 8e-05 0.0052 17.1 2.1 1 23 460 483 460 483 0.95

6 15 0.74 48 4.6 4.3 1 23 524 546 524 546 0.87

7 15 0.0041 0.27 11.7 0.4 1 23 552 575 552 575 0.98

8 15 0.027 1.8 9.1 0.4 3 19 584 600 583 601 0.95

9 15 0.00016 0.011 16.1 5.6 1 23 610 632 610 632 0.97

10 15 0.042 2.8 8.5 1.2 2 23 638 659 637 659 0.96

11 15 9.5e-06 0.00062 20.0 1.0 1 23 668 690 668 690 0.98

12 15 0.00023 0.015 15.7 0.5 3 23 698 718 696 718 0.97

13 15 5.8e-05 0.0038 17.5 0.5 1 23 724 746 724 747 0.95

14 15 0.049 3.2 8.3 0.4 1 23 757 779 757 779 0.97

15 15 0.00052 0.034 14.5 0.8 1 23 1285 1307 1285 1307 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.8e-05	0.0018	18.5	1.0	1	23	152	174	152	174	0.97
2	15	0.00086	0.056	13.8	1.2	3	23	182	202	180	202	0.94
3	15	9.4e-05	0.0061	16.9	0.1	1	23	378	400	378	400	0.98
4	15	0.0037	0.24	11.9	2.4	1	23	406	428	406	428	0.98
5	15	8e-05	0.0052	17.1	2.1	1	23	460	483	460	483	0.95
6	15	0.74	48	4.6	4.3	1	23	524	546	524	546	0.87
7	15	0.0041	0.27	11.7	0.4	1	23	552	575	552	575	0.98
8	15	0.027	1.8	9.1	0.4	3	19	584	600	583	601	0.95
9	15	0.00016	0.011	16.1	5.6	1	23	610	632	610	632	0.97
10	15	0.042	2.8	8.5	1.2	2	23	638	659	637	659	0.96
11	15	9.5e-06	0.00062	20.0	1.0	1	23	668	690	668	690	0.98
12	15	0.00023	0.015	15.7	0.5	3	23	698	718	696	718	0.97
13	15	5.8e-05	0.0038	17.5	0.5	1	23	724	746	724	747	0.95
14	15	0.049	3.2	8.3	0.4	1	23	757	779	757	779	0.97
15	15	0.00052	0.034	14.5	0.8	1	23	1285	1307	1285	1307	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGAACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAATCAGAGATGACAGCAGCATATTTGGTCAACGCTGACGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTCATCTTTATGGCACGCGACGGCCAACTGAGCGAAATCATCGCCGCCAATGAGGCAaatggcggcagcagcacagTGCTAATCACGGAGAGCGACGGAAATAACGGTGTCGAGTACGCCGAGTCCTTTGACGATGATACCCAAGTCGTCACCGAGGAGATCATCACGGACGATTGGGTCCAGCATCAGGGTGCAGAGCGagTGGAAATTGCCGCTGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGCAGCAGAATGAGTATATGGCGATGCGTCCCTATCCCTGTGACTTTTGCAGTCGACGGTTTCGGAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGTCCCCATCTCTGCAAGCTGTGCGGGGCGCGTTTCTCGCGTCGCGCGGAGCTCATCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATCAAATTtgagccacaacagcagctgcaacaacagcagcagcgacaaattGATGATCATTTCTACGAGCAGGAATGGCCGCTGTatcaggaacaggagcaggtcgaggagcagctggagcagatcgaggagcagcagcagttggaacagcatcagcagctatTGCAACACTTGGTGGCACCACCAACCGCTGCCCGGGGACGCATCAGTCGCTTAAAGCTCAAGGAGGAGAGTTCGCAGTATATTGTGATTGCCTCCGATAAAcaggagacggagacggagacggagttgcctcaatatttgcattgcgAGGCGAATTGCGATCAATCACatgccaccaacaacaaccaactcCAATCAACATCCAACAATgatgttgcaactgttgctgctgctgctgctgctgatggggCACatgggcaggggcaggggcaggggcaggcaACGCTGCGTTTTCCCGTGCTCGACGAGAGCAAACCCTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAACTGCAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCATCGGCGGGCGAGGAGGATACGGCGAGCGAATCGGAAGCGGAACAGCTTTACGGCAATTACTACTGCGGCGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacagcaagcagctggctgcaacaacagctagcaacaacaacaacagtgtggcaactgcaacagcaacggatgcagctgcagctgcaactgatgccgatgctgatgatgcCAAAGATGCGACACATTGTTGCCACACGTGCGGCAAGTCATTTCTCAGCGTACTCAAACTGCTCGCGCATACCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGCGTCAGTTTCTACGAGGAGCAGGCCATAAAGCGGCACCTGAACACGCGGCATCCGCATGAGCTGAAGCCCAATTCGTGTGTGCTGTGTGGCAAGGAGTGTCGGGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCACGGGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAACGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAGGTGTGCCACGAGGAGTTCCCAGATGGACGCACCTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCGCGCAGCTCGCAGCAGATTCATGTGCGCATCCATACGGGTGAGAGGCCCTACGGCTGTCACTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGCAAACACGAACGCATCCACACGGGCGAGAAGCCCTATGCCTGCTCCGTCTGTCCGCGTGCCTTCAATCAGCGTGTCGTGTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGTGGCACGTACCATTGCACGGTCTGCTCCGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTacTGGTCCACGTAAATATAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCGCGCGGAGCACAAGGCTGGCGGGGGCGAAGGCGAGGAGGAGGATTATGGCAGCGACTTGGACTACTGCGATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAGCCGCagagccaccaccaccagccaCCAAAAAGGcgaaacgcaaacgcaaagcGCCAATTAAAACCGGCGATGAGCAAAGATTGTGGGATGAGAAATTCCTGCAGCAGGCGAGCAATGGGAACAGCGATGAGGCCTACAAGAGTTTCTTTCAAATGGACTCGCTGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCACGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAAAACTCAAAACAGGCAatcgcagcagcaaaagaaggGCAGGCAAATCTGGgggaggagcagcaggaggaaCAGCAGGAGTAGTAGAAGCCGTTGCTGCTCCACGTCCCCGCATGATACACACGGCCAAGTCGCAGCAGACAACGTCAAGGAAATCCCGCACAAGGAGCTATGTCACACGCACCAGCACCaatgagcagctgcagcagcagcagcagcagacaggaggaggagcaagCCTCATCAAATCGCGCATTGTGGATGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCAAACAGGAGCAGgaacatcaacagcatcatcagcatcatcagcaacagcagcaccagcagcagcagcagcgagtccAACTGCTCTTCGACGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCGAGCATTGTCCAAGATCTCGAGGAGATATTGCGTAGTCCCCCCAAGCATGAGCGAAACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTCATCAAGATCGAGCCAACGTCGCCGGATCTACGCGAAATGGTCGAgagccagcagccagccacaCTGCCCACATCCTCCTCCGCCGCCTGCTCAACGGCGGCACGCACTTCCCGCCACCTGCGACAGCTGACTGCCAAtcgttccagttccagttccatttCCACTGCCACTTCCGGTTCCAGTTCCAGTGCCGCTGCCAGCACGCGAGCCGCTGCCAAGCGCAATGCCAGCAAGCAGCTTGCCAAGAAATCCAAAGCCAATTCATCATCGTCTTATCTCAGCTATGGTGTCGACTCCTAtaatgtgggcgtggcagccaGTGCCAATGGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCAGCGGACGCAGCCGATGCAGCTGCGAAGGAAGCAGCGAGCAACACGGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCAATTTTCCAGATCGCTCACAGCTGCTGgaacacatgcacatacacatctAG
Protein Sequence: MNNPNYGGIQWIQQESSAVVDDSESEMTAAYLVNADANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNNGVEYAESFDDDTQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQQQQQRQIDDHFYEQEWPLYQEQEQVEEQLEQIEEQQQLEQHQQLLQHLVAPPTAARGRISRLKLKEESSQYIVIASDKQETETETELPQYLHCEANCDQSHATNNNQLQSTSNNDVATVAAAAAADGAHGQGQGQGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNCSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNYYCGECGISFHRQDLLRRHSKQQHSKQLAATTASNNNNSVATATATDAAAAATDADADDAKDATHCCHTCGKSFLSVLKLLAHTEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCHYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGGEGEEEDYGSDLDYCDLDVENVDELLQEAAAEPPPPATKKAKRKRKAPIKTGDEQRLWDEKFLQQASNGNSDEAYKSFFQMDSLVVVNDQTLQPVDAGVATTKLQQAEIKEQKLKTGNRSSKRRAGKSGGGAAGGTAGVVEAVAAPRPRMIHTAKSQQTTSRKSRTRSYVTRTSTNEQLQQQQQQTGGGASLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHQHHQQQQHQQQQQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPATLPTSSSAACSTAARTSRHLRQLTANRSSSSSISTATSGSSSSAAASTRAAAKRNASKQLAKKSKANSSSSYLSYGVDSYNVGVAASANGSSDVSSGFFSISEVVSAADAADAAAKEAASNTERRTRCFECEMCSSNFPDRSQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -