Basic Information

Insect: Drosophila heteroneura
Gene Symbol: zfh1
Assembly: GCA_035042245.1
Location: JAWNLO010000552.1:201712-207759[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.8e-05 0.0018 18.5 1.0 1 23 152 174 152 174 0.97

2 15 0.00086 0.055 13.9 1.2 3 23 182 202 180 202 0.94

3 15 9.3e-05 0.0059 16.9 0.1 1 23 373 395 373 395 0.98

4 15 0.00032 0.02 15.2 0.9 1 23 401 423 401 423 0.98

5 15 8e-05 0.0051 17.1 2.1 1 23 455 478 455 478 0.95

6 15 0.74 47 4.6 4.3 1 23 519 541 519 541 0.87

7 15 0.0041 0.26 11.7 0.4 1 23 547 570 547 570 0.98

8 15 0.027 1.7 9.1 0.4 3 19 579 595 578 596 0.95

9 15 0.00016 0.01 16.1 5.6 1 23 605 627 605 627 0.97

10 15 0.042 2.7 8.5 1.2 2 23 633 654 632 654 0.96

11 15 9.5e-06 0.0006 20.0 1.0 1 23 663 685 663 685 0.98

12 15 0.0011 0.068 13.5 0.1 3 23 693 713 691 713 0.97

13 15 5.8e-05 0.0037 17.5 0.5 1 23 719 741 719 742 0.95

14 15 0.049 3.1 8.3 0.4 1 23 752 774 752 774 0.97

15 15 0.00052 0.033 14.5 0.8 1 23 1282 1304 1282 1304 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.8e-05	0.0018	18.5	1.0	1	23	152	174	152	174	0.97
2	15	0.00086	0.055	13.9	1.2	3	23	182	202	180	202	0.94
3	15	9.3e-05	0.0059	16.9	0.1	1	23	373	395	373	395	0.98
4	15	0.00032	0.02	15.2	0.9	1	23	401	423	401	423	0.98
5	15	8e-05	0.0051	17.1	2.1	1	23	455	478	455	478	0.95
6	15	0.74	47	4.6	4.3	1	23	519	541	519	541	0.87
7	15	0.0041	0.26	11.7	0.4	1	23	547	570	547	570	0.98
8	15	0.027	1.7	9.1	0.4	3	19	579	595	578	596	0.95
9	15	0.00016	0.01	16.1	5.6	1	23	605	627	605	627	0.97
10	15	0.042	2.7	8.5	1.2	2	23	633	654	632	654	0.96
11	15	9.5e-06	0.0006	20.0	1.0	1	23	663	685	663	685	0.98
12	15	0.0011	0.068	13.5	0.1	3	23	693	713	691	713	0.97
13	15	5.8e-05	0.0037	17.5	0.5	1	23	719	741	719	742	0.95
14	15	0.049	3.1	8.3	0.4	1	23	752	774	752	774	0.97
15	15	0.00052	0.033	14.5	0.8	1	23	1282	1304	1282	1304	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGAACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAATCAGAGATGACAGCAGCATATTTGGTCAACGCTGACGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTTATTTTTATGGCACGCGACGGCCAACTGAGCGAAATCATCGCCGCCAATGAGGCAaatggcggcagcagcacagTGCTAATCACGGAGAGCGACGGAAATAACGGTGTCGAGTACGCCGAGTCCTTTGACGACGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGTGCAGAGCGagTGGAAATTGCCGCTGAGCAAATCGCCGGCACCGGCAGCTCCCAGGAACTGTTGGACATGCAACAGAATGAGTATATGGCGATGCGTCCCTATCCCTGCGACTTTTGCAGTCGACGGTTTCGGAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGGCCCCATCTCTGCAAGCTGTGCGGGGCGCGTTTCTCGCGTCGCGCGGAGCTCATCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATCAAATTtgagccacaacagcagctgcaacaacagcagcagcagcagcagcgacaaattGAGGATCATTTCTATGAGCAGGAATGGCCGCTGTatcaggaacaggaacaggagcaggagcaggtcgaggagcagctggagcagatcgaggagcagcagctattGCAACACTTGGTGGCACCACCAACCGCTGCCAGGGGACGCATCAGTCGCTTAAAGCTCAAGGAGGAGAGTTCGCAGTATATTGTGATTGCCTCCGATAAACAGGAggcggagacggagacggagttGCCTCAATACATGCATTGCGAGGCGAATTGCGACCAATCACatgccaccaacaacaatcaactcCAATCAACATCCAACAATgatgttgcaactgctgctgctgctgatgaggCACATGGGCAGGGACATGGGCAGGCAACGCTGCGTTTTCCCGTGCTCGACGAAAGCAAACCCTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGGGTGGATTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAACTACAGTCTTCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCATCGGCGGGCGAGGAGGATACGGCGAGCGAATCGGAAGCGGAACAGCTTTACGGCAATTACTACTGCGGCGAATGCGGCATCTCCTTTCACCGGCAGGATTTGCTGCGGCgccacagcaaacagcagcacagcaagcagctggctgcaacaacagctggtaacaacaacaacagtgtggcaactgcaacagcaacggatgcagctgcagctgcaactgatgCCGAAGCTGATGATGCCAAAGATGCGCCACATTGTTGCCACACGTGCGGCAAATCATTTCTCAGCGTACTCAAACTGCTCGCGCATACCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGCGTCAGTTTCTACGAGGAGCAGGCCATTAAGCGGCACCTGAATACGCGGCATCCGCATGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcaAGGAGTGTCGAGATCGGAAGGCGCTGATCAAACATGCCTGGGATCATTCACGGGAGAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAATTTCCACAACAAGGCGCGGCTGAAACGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCAGATGGACGCACCTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCGCGCAGCTCGCAACAGATTCATGTGCGCATCCATACGGGTGAGAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGCAAACACGAGCGCATCCACACGGGCGAGAAGCCCTATGCCTGCTCCGTCTGTCCGCGTGCCTTCAATCAGCGTGTCGTGTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGCGGCACGTATCATTGCACGGTCTGCTCCGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTACTGGTCCACGTAAATATAAACGTCGTCGGAAACTGCAGCCGCATGAGATTGCGCACATGCGCGCAGAGCACAAGGCTGGCGGTGGCGAAGGCGAGGATGAGGATTATGGCAGCGACTTGGACTACTGCGATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAGCCGCagagccaccaccaccagccaCCAAAAAAGcgaaacgcaaacgcaaagcGCCAATAAAAACCGGCGATGAGCAAAGATTGTGGGATGAGAAATTCCTGCAGCAGGCGAGCAATGGGAACAGCGATGAGGCCTACAAGAGTTTCTTTCAAATGGACTCGCTGGTCGTGGTCAATGACCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCACGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAAAACTCAAAACAGGCAatcgcagcagcaaaagaaggGCAGGCAAATCTGGgggaggagcagcaggaggaacAGCAGGAGTAGTagaagctgttgctgctccactTCCCCGCATGATACACACGGCCAAGTCGCAGCAGACAACGTCAAGGAAGTCCCGCACAAGGAGTTACGTCACACGCACCAGCACCaatgagcagctgcagcagcagcagcagccaggagGAGGAGCAAGCCTCATCAAATCGCGCATTGTGGATGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCAAACAGGAGCAGgaacatcaacagcatcatcagcaacagcagcaccagcaccagcagcagcaccagcgaGTCCAACTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCGAGCATTGTCCAAGATCTCGAGGAGATATTGCGTAGTCCCCCCAAGCATGAGCGAAACGATCGACGGCTGCGCTTCACCAGTGAATCGTCGACGACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTCATCAAGATCGAGCCAACGTCGCCGGATCTACGCGAAATGGTCGAgagccagcagccagccacaCTGCCCACATCCTCCTCCGCCGCCTGCTCAACGGCGGCACGCACTTCCCGCCACCTGCGACAGCTGACTGCCAATGGTTCCAGTTCCATTTCCACTGCCACTTCCAGTTCCAGTGCCGCTGGCAGCACGCGAGCCGCTGCCAAGCGCAATGCCAGCAAGCAGCTTGCCAAGAAATCCACTTCCAATAGCAGCAAAGCCAACTCATCATCGTCTTATCTCAGCTATGGCGTCGACTCCTATAATGTGGGCGTGTCAGCCAGTGCCAATGGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCAGCGGATGCAGCCGATGCAGCTGCgaaggcggcggcggcagcagccagcaaaacgGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCAATTTTCCAGATCGCTCACAGCTGCTGgaacacatgcacatacacatctAG
Protein Sequence: MNNPNYGGIQWIQQESSAVVDDSESEMTAAYLVNADANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNNGVEYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGTGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQQQQQQQQRQIEDHFYEQEWPLYQEQEQEQEQVEEQLEQIEEQQLLQHLVAPPTAARGRISRLKLKEESSQYIVIASDKQEAETETELPQYMHCEANCDQSHATNNNQLQSTSNNDVATAAAADEAHGQGHGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNYYCGECGISFHRQDLLRRHSKQQHSKQLAATTAGNNNNSVATATATDAAAAATDAEADDAKDAPHCCHTCGKSFLSVLKLLAHTEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGGEGEDEDYGSDLDYCDLDVENVDELLQEAAAEPPPPATKKAKRKRKAPIKTGDEQRLWDEKFLQQASNGNSDEAYKSFFQMDSLVVVNDQTLQPVDAGVATTKLQQAEIKEQKLKTGNRSSKRRAGKSGGGAAGGTAGVVEAVAAPLPRMIHTAKSQQTTSRKSRTRSYVTRTSTNEQLQQQQQPGGGASLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHQQQQHQHQQQHQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPATLPTSSSAACSTAARTSRHLRQLTANGSSSISTATSSSSAAGSTRAAAKRNASKQLAKKSTSNSSKANSSSSYLSYGVDSYNVGVSASANGSSDVSSGFFSISEVVSAADAADAAAKAAAAAASKTERRTRCFECEMCSSNFPDRSQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -