Basic Information

Insect: Drosophila nigritarsus
Gene Symbol: zfh1
Assembly: GCA_035044305.1
Location: JAWNMF010000917.1:191979-196934[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.1e-05 0.0016 18.9 1.3 1 23 149 171 149 171 0.97

2 15 0.00089 0.066 13.9 1.2 3 23 179 199 177 199 0.94

3 15 9.7e-05 0.0072 16.9 0.1 1 23 366 388 366 388 0.98

4 15 0.00033 0.025 15.2 0.9 1 23 394 416 394 416 0.98

5 15 0.00012 0.0089 16.6 2.3 1 23 448 471 448 471 0.94

6 15 0.025 1.8 9.3 1.5 1 23 517 539 517 539 0.93

7 15 0.0043 0.32 11.7 0.4 1 23 545 568 545 568 0.98

8 15 0.028 2.1 9.1 0.4 3 19 577 593 576 594 0.95

9 15 0.00017 0.013 16.1 5.6 1 23 603 625 603 625 0.97

10 15 0.044 3.3 8.5 1.2 2 23 631 652 630 652 0.96

11 15 9.8e-06 0.00073 20.0 1.0 1 23 661 683 661 683 0.98

12 15 0.0011 0.083 13.5 0.1 3 23 691 711 689 711 0.97

13 15 6e-05 0.0045 17.5 0.5 1 23 717 739 717 740 0.95

14 15 0.05 3.8 8.3 0.4 1 23 750 772 750 772 0.97

15 15 0.0039 0.29 11.8 0.5 1 23 1283 1305 1283 1305 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.1e-05	0.0016	18.9	1.3	1	23	149	171	149	171	0.97
2	15	0.00089	0.066	13.9	1.2	3	23	179	199	177	199	0.94
3	15	9.7e-05	0.0072	16.9	0.1	1	23	366	388	366	388	0.98
4	15	0.00033	0.025	15.2	0.9	1	23	394	416	394	416	0.98
5	15	0.00012	0.0089	16.6	2.3	1	23	448	471	448	471	0.94
6	15	0.025	1.8	9.3	1.5	1	23	517	539	517	539	0.93
7	15	0.0043	0.32	11.7	0.4	1	23	545	568	545	568	0.98
8	15	0.028	2.1	9.1	0.4	3	19	577	593	576	594	0.95
9	15	0.00017	0.013	16.1	5.6	1	23	603	625	603	625	0.97
10	15	0.044	3.3	8.5	1.2	2	23	631	652	630	652	0.96
11	15	9.8e-06	0.00073	20.0	1.0	1	23	661	683	661	683	0.98
12	15	0.0011	0.083	13.5	0.1	3	23	691	711	689	711	0.97
13	15	6e-05	0.0045	17.5	0.5	1	23	717	739	717	740	0.95
14	15	0.05	3.8	8.3	0.4	1	23	750	772	750	772	0.97
15	15	0.0039	0.29	11.8	0.5	1	23	1283	1305	1283	1305	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAAGCAGAGATGACAGCAGCCTATTTGGTCAACGCTGCCGCCAATGGAAGCATTTCCAACGATGACGAGCTCGATCATATTGCAGCCGAGAATCTCATCTTTATGGCACGCGACCGCCAACTGAGCGAAATCATTGCCGCAAATGAGGCAAATGGCGGCAGCACCACAGTGCTAATCACGGAGAGAGACGGCGTGGAATACGCCGAGTCCTTTGACGATGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgtGGAAATTGCAGCAGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGCAACAGAATGAATATATGTCGATGCGTCCATATCCCTGTGACTTTTGCAGTCGACGCTTTCGCAAGAAGGCGAGCCTCAACAATCATATGCAGGCGCATCAGACTGATCGTCCCCATCTCTGCAAACTGTGCGGAGCGCGTTTCTCGCGACGTGCGGAGCTCATCAGTCACTTCAAGGCTCACGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATTAAATTtgagccacaacagcagctgcaaccgctgcaacagcagcagcagcagcagcgccaaatTGATGATCATTTCTATGAGCAGGAATGGCCGCTGGTCgaggagcagctggagcagatcgaggagcagcagcagcagcagctggagcagttTCAGCAGCGGTTGCAACATTCGGTTGCGCCACCAACCGCTGCTCGTGGACGTATCAGTCGATTGAAACTCAAGGAGGAGAGCTCGGAATATATTGTGATTGCCTCCGATAAACCGGAGGCGGAGTTGCCTCAATACATGCATTGCGAGGCGAATGGCGATCAATCACttgccaccaacaacagccaagTCCAATCAACATCATCCAATgatgttgcaactgctgctgctgctgctgctgctgatgaggCAGAGGGGCAGGCAACGCTGCGCTTTCCCGTGCTCGACGAGAGCAAACCGTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCTTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAATTCGGAATATGATCCCGCATCGGCGGGCGAGGAGGATACGGCGAGTGAATCGGAAGCGGAACAGCTTTACGGTAATTTCTACTGTGGAGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCGccacagcaaacagcagcacagTAAGCAGctggctgcaacaacagctggtggcaacaacaacagcagtgtagcaactgcaacagcaacggaTGCAATGGGTGCCGCagatgcaactgcaactgatgCCGATGCGGATGATTCCAAAGATGCGACACATTGTTGCCGCACGTGCGGCAAATCATTTCCCAGCGTACTCAAACTGCTCGCCCATGCCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGAGTCAGCTTCTACGAGGAGCAGGCGATAAAGCGGCACCTGAACACGCGGCATCCGCACGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcAAGGAGTGTCGCGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCGCGAGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAGCGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCCGATGGACGCACTTTGTCCAATCATCGGCATTCCCACAGCACAACGTCACCGGGCAAACTCTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCACGCAGCTCGCAACAGATTCATGTGCGCATCCACACGGGTGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGACGGCGGCACTCTCCGCAAACACGAACGCATCCATACGGGCGAGAAGCCCTATGCGTGCTCCGTCTGCCCGCGTGCCTTCAATCAGCGTGTCGTCTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACTTGGCACGTATCATTGCACTGTGTGCTCGGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATATGAACACAGCCAAACAGCGACAGCCAATTaCTGGGCCACGTAAATACAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCGCGCCGAGCACAAGGCTGGCGGCGGCGATGGCGAGGCTGGCGAGGAGGAGGATTATGCCAGCGACTTGGACTACTGCCATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAACGGCAGAGCCACCATCACCCACCAAAAAAGCGAAACGCAAACGCAAAGCGCCAATTAAAACCGGTGATGAGCAAAGATTGTGGGATGAGAAATTCCCGCAGCAGGCGAGCAATGGGAATAGCGATGAGGCCTACAAGAGTTTCTTCCAGATGGACTCAATGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCTCGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAACACTGAAGACAGGCAATCGCAGTAGCAAAAGAAGGGCAGGTAAAGCTGGGGGAGGAGGAGCTGGCGCACCAGGAGGgggaggaggagctgctgctactgctgctccACGTCCCCGGATGATACACACGGCCAAGTCGCAGCAGACAACGGCAAGGAAATCCCGCACAAGGAGTTATGTCACACGCACCAGCAccaatgagcagcagcagggggGAGGAGCAAGTGGAGGAAGCCTCATCAAATCCCGGATTGTAGATGACTACGAGATCATCTCCCCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCAAACAGGAGCAGGaacatcaacagcatcatcatcatcatcatcagcaccagcatcatcagcagcagcaccagagAGTCCAATTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCCAGCATTGTCCAAGATCTCGAAGAGATTTTGCGTAGTCCCCCGAAGCATGATCGGAACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACTCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTTATCAAGATCGAGCCCACGTCGCCGGATCTCCGCGAAATGGTCGAGAGCCAGCAGCCAGCGGCACTGCCCACATCTTCCTCCGCCTGCTCAACGGCAGCACGCACTTCCCGCCACCTGCGACAACTGACTGCCAATGGTTCCAGTTCCATTTCCACTGCCACATCCAGTTCCAGTGGCGCTCCAAGTACGCGAGCCGCTTCCAGGCGCAATGCCAGCAAACAGCTTTCCAAGAAATCCActtccaacagcaacaaaggcaACGCATCATCGTCTTATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcaaccAGTGCCAATAGCTCCTCGGATGTCAGTTCCGgtttcttttccatttctgAGGTCGTCTCGGCGGCGGATGCAGCCGATGCAGCTGCgaaggcggcggcggcagcagccagcaaaacGGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCTATTTCCCAGATCGCGCCCAGCTGCTGgaacacatgcacatacacatctAA
Protein Sequence: MNNPDYGGIQWIQQESSAVVDDSEAEMTAAYLVNAAANGSISNDDELDHIAAENLIFMARDRQLSEIIAANEANGGSTTVLITERDGVEYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMSMRPYPCDFCSRRFRKKASLNNHMQAHQTDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQPLQQQQQQQRQIDDHFYEQEWPLVEEQLEQIEEQQQQQLEQFQQRLQHSVAPPTAARGRISRLKLKEESSEYIVIASDKPEAELPQYMHCEANGDQSLATNNSQVQSTSSNDVATAAAAAAADEAEGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNFYCGECGISFHRQDLLRRHSKQQHSKQLAATTAGGNNNSSVATATATDAMGAADATATDADADDSKDATHCCRTCGKSFPSVLKLLAHAEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAALGTYHCTVCSADLSSSNDLIQHLIQHSDMNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGGDGEAGEEEDYASDLDYCHLDVENVDELLQEATAEPPSPTKKAKRKRKAPIKTGDEQRLWDEKFPQQASNGNSDEAYKSFFQMDSMVVVNDQTLQPVDAGVASTKLQQAEIKEQTLKTGNRSSKRRAGKAGGGGAGAPGGGGGAAATAAPRPRMIHTAKSQQTTARKSRTRSYVTRTSTNEQQQGGGASGGSLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHHHHHQHQHHQQQHQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHDRNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPAALPTSSSACSTAARTSRHLRQLTANGSSSISTATSSSSGAPSTRAASRRNASKQLSKKSTSNSNKGNASSSYLSYGVDSYNVGVATSANSSSDVSSGFFSISEVVSAADAADAAAKAAAAAASKTERRTRCFECEMCSSYFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -