Basic Information

Insect: Drosophila glabriapex
Gene Symbol: zfh1
Assembly: GCA_035042305.1
Location: JAWNLN010000018.1:12015400-12021477[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.9e-05 0.0018 18.5 1.0 1 23 152 174 152 174 0.97

2 15 0.00088 0.055 13.8 1.2 3 23 182 202 180 202 0.94

3 15 4e-05 0.0025 18.1 0.2 1 23 386 408 386 408 0.98

4 15 0.00016 0.0099 16.2 0.6 1 23 414 436 414 436 0.98

5 15 0.00012 0.0074 16.6 2.3 1 23 468 491 468 491 0.94

6 15 0.75 47 4.6 4.3 1 23 535 557 535 557 0.87

7 15 0.0042 0.27 11.7 0.4 1 23 563 586 563 586 0.98

8 15 0.028 1.8 9.1 0.4 3 19 595 611 594 612 0.95

9 15 0.00017 0.01 16.1 5.6 1 23 621 643 621 643 0.97

10 15 0.043 2.7 8.5 1.2 2 23 649 670 648 670 0.96

11 15 9.7e-06 0.00061 20.0 1.0 1 23 679 701 679 701 0.98

12 15 0.0011 0.069 13.5 0.1 3 23 709 729 707 729 0.97

13 15 5.9e-05 0.0037 17.5 0.5 1 23 735 757 735 758 0.95

14 15 0.05 3.1 8.3 0.4 1 23 768 790 768 790 0.97

15 15 0.00053 0.033 14.5 0.8 1 23 1303 1325 1303 1325 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.9e-05	0.0018	18.5	1.0	1	23	152	174	152	174	0.97
2	15	0.00088	0.055	13.8	1.2	3	23	182	202	180	202	0.94
3	15	4e-05	0.0025	18.1	0.2	1	23	386	408	386	408	0.98
4	15	0.00016	0.0099	16.2	0.6	1	23	414	436	414	436	0.98
5	15	0.00012	0.0074	16.6	2.3	1	23	468	491	468	491	0.94
6	15	0.75	47	4.6	4.3	1	23	535	557	535	557	0.87
7	15	0.0042	0.27	11.7	0.4	1	23	563	586	563	586	0.98
8	15	0.028	1.8	9.1	0.4	3	19	595	611	594	612	0.95
9	15	0.00017	0.01	16.1	5.6	1	23	621	643	621	643	0.97
10	15	0.043	2.7	8.5	1.2	2	23	649	670	648	670	0.96
11	15	9.7e-06	0.00061	20.0	1.0	1	23	679	701	679	701	0.98
12	15	0.0011	0.069	13.5	0.1	3	23	709	729	707	729	0.97
13	15	5.9e-05	0.0037	17.5	0.5	1	23	735	757	735	758	0.95
14	15	0.05	3.1	8.3	0.4	1	23	768	790	768	790	0.97
15	15	0.00053	0.033	14.5	0.8	1	23	1303	1325	1303	1325	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGAACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAATCAGAGATGACAGCAGCATATTTGGTCAACGCTGACGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTCATCTTTATGGCACGCGACGGCCAACTGAGCGAAATCATCGCCGCCAATGAGGCAaatggcggcagcagcacagtGCTAATCACGGAGAGCGATGGAAATACCGGTGTCGAGTACGCCGAGTCCTTTGAAGATGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGTGCAGAGCGagTGGAAATTGCCGCTGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGCAACAGAATGAGTATATGGCGATGCGTCCCTATCCCTGTGACTTTTGCAGTCGACGGTTTCGGAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGTCCCCATCTCTGCAAGCTATGCGGGGCGCGTTTCTCGCGTCGCGCGGAGCTTATCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGACGAAGAGGCAGCCGCGGCAGCCATCAAATTtgagccacaacagcagctacaacaacagcagcagcagcagcagcagcagcgacaaattGAGGATCATTTCTATGAGCAGGAATGGCCGCTGTatcaggaacaggaacaggagcaggtCGAGGAGCAGCTAGAGCAGatcgaggaggaggagcagcagcagcagcagcagcagcagttggaacatcatcagcagctgttgcaacaaTTGGTGGCACCACCAACCGCTGCCCGGGGACGCATCAGTCGATTAAAGCTCAAGGAGGAGAGTTCGCAATATATTGTGATTGCCTCCGATAAACCGGAGgcagagacggagacggagttGCCTCAATACATGCATTGCGAGGCGAATTGCGATCAATCActtgccaccaacaacaaccaactcCAGTCAACATCGAACAATgatgttgcaactgctgctgctgatggagCACAGGGGCAGGCGCAGGGGCAGGCAACGCTGCGTTTTCCCGTGCTCGACGAGAGCAAACCCTTCGTCTGTCAGCAGTGCGGATTGTCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCGTTTGAATGCAATGAGTGCCAGGAGATGTTCTGGGACAACTACAGTCTACAGGAGCATCAGAAGACACATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCATCGGCGGGCGAGGAGGATACGGCGAGCGAATCGGAAGCGGAACAGCTTTACGGTAATTTCTACTGCGGCGAATGTGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCGccacagcaagcagcagcacagcaagcAGCTgcctgcaacaacagctggtaacaacaacaacaacaacaacactgtgacaactgcaacagcaacggatgcagctgcagctccaactgatgccgatgctgatgatgccAAAGATGCGCCACATTGTTGCCACACGTGCGGCAAATCATTTCTCAGTGTACTCAAACTGCTCGCCCATACCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTCCTGTGCGGTGTCAGTTTCTACGAGGAGCAGGCCATAAAGCGGCACCTGAATACGCGGCATCCGCATGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcaAGGAGTGTCGAGACCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCACGGGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAACGACACATGGCATCGCATCGTGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCAGATGGGCGCACCTTGTCTAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCGCGCAGCTCGCAACAGATTCATGTGCGCATCCATACGGGTGAAAGGCCATACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGCAAACACGAACGCATCCACACGGGCGAGAAGCCCTATGCCTGCTCCGTCTGTCCGCGTGCCTTCAATCAGCGTGTCGTGTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGTGGCACGTATCATTGCACGGTCTGCTCCGCGGATTTGAGCTCGTCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTaCTGGTCCACGTAAATATAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCTCGTAGAGCACAAGGCTGGCGGTGGCGAAGGCGAGGAGGAGGATTATGGCAGCGACTTGGACTACTGCGATCTGGATGTGGAGAATGTGGATGAACTGCTGCAAGAGGCAGCCGCagagccaccaccaccagccaGCAAAAAGGcgaaacgcaaacgcaaagcGCCAAATAAAACCGGCGATGAGCAAAGATTGTGGGATGAGAAATTCCTGCAGCAGGCGAGCAATGGGAACAGCGATGAGGCCTACAAGAGTTTCTTTCAAATGGACTCGCTGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCCGGTGTTGCCACGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAAAACTCAAAGCAGGCaatcgcagcagcaaaagaaggGCAGGCAAATCTGggggaggagcagcaggaggaacagcaggagcagtagaagctgttgctgctccacGTCCCCGCATGATACACACGGCCAAGTCGCAGCAGACAACGTCAAGGAAGTCCCGCACAAGGAGTTATGTCACTCGCACCAGCAccaatgagcagcagcagcagcagcagcagcatcagcagccagGAGGAGGAGCAAGCCTCATCAAATCGCGCATTGTGGATGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCAAACAGGAGCAGgaacatcaacagcatcatcagcaacagcagcagcagcagcaacagcagcgcgtCCAACTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGAACTACGAGAAATATAATCCGAGCATTGTCCAAGATCTCGAGGAGATATTGCGTAGTCCCCCCAAGCATGAGCGAAACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACATCATCTCATCAAGATCGAGCCAACGTCACCGGATTTACGCGAAATGGTCGAgagccagcagccagccacaCTGCCCACATCTTCCCCCGCCGCCTGCTCAACGGCGGCACGCACTTCCCGCCACCTGCGACAGCTGACTGCCAAtggttccagttccagttccatttCCACTGCTacttccagttccagttccagtgcCGCTGCCAGCACGCGAGCCGCTGCCAAGCGCAATGCCAGCAAGCAGCTTGCCAAGAAATCCATTTCTAATAGCAGCAAAGCCAACTCTTCATCATCTTATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcatccAGTGCCAATGGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCAGCGGATGCTGCCGATGCAGCTGCgaaggcggcggcggcagcagctagCAAAACGGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCAATTTTCCAGATCGCTCTCAGCTGCTGgaacacatgcacatacacatctAG
Protein Sequence: MNNPNYGGIQWIQQESSAVVDDSESEMTAAYLVNADANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNTGVEYAESFEDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQQQQQQQQQQRQIEDHFYEQEWPLYQEQEQEQVEEQLEQIEEEEQQQQQQQQLEHHQQLLQQLVAPPTAARGRISRLKLKEESSQYIVIASDKPEAETETELPQYMHCEANCDQSLATNNNQLQSTSNNDVATAAADGAQGQAQGQATLRFPVLDESKPFVCQQCGLSFAREKALVSHIKNHRVDSPFECNECQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNFYCGECGISFHRQDLLRRHSKQQHSKQLPATTAGNNNNNNNTVTTATATDAAAAPTDADADDAKDAPHCCHTCGKSFLSVLKLLAHTEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMLVEHKAGGGEGEEEDYGSDLDYCDLDVENVDELLQEAAAEPPPPASKKAKRKRKAPNKTGDEQRLWDEKFLQQASNGNSDEAYKSFFQMDSLVVVNDQTLQPVDAGVATTKLQQAEIKEQKLKAGNRSSKRRAGKSGGGAAGGTAGAVEAVAAPRPRMIHTAKSQQTTSRKSRTRSYVTRTSTNEQQQQQQQHQQPGGGASLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHQQQQQQQQQQRVQLLFDDSHLLIDAGLLREKNYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEHHLIKIEPTSPDLREMVESQQPATLPTSSPAACSTAARTSRHLRQLTANGSSSSSISTATSSSSSSAAASTRAAAKRNASKQLAKKSISNSSKANSSSSYLSYGVDSYNVGVASSANGSSDVSSGFFSISEVVSAADAADAAAKAAAAAASKTERRTRCFECEMCSSNFPDRSQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -