Basic Information

Insect: Drosophila hawaiiensis
Gene Symbol: zfh1
Assembly: GCA_037043685.1
Location: JBAMBA010000209.1:1937125-1943106[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.7e-05 0.0018 18.6 1.0 1 23 152 174 152 174 0.97

2 15 0.00084 0.055 13.9 1.2 3 23 182 202 180 202 0.94

3 15 9.1e-05 0.006 16.9 0.1 1 23 377 399 377 399 0.98

4 15 0.00031 0.021 15.2 0.9 1 23 405 427 405 427 0.98

5 15 0.00011 0.0074 16.6 2.3 1 23 459 482 459 482 0.94

6 15 0.72 47 4.7 4.3 1 23 525 547 525 547 0.87

7 15 0.004 0.27 11.7 0.4 1 23 553 576 553 576 0.98

8 15 0.027 1.8 9.2 0.4 3 19 585 601 584 602 0.95

9 15 0.00016 0.01 16.2 5.6 1 23 611 633 611 633 0.97

10 15 0.041 2.7 8.6 1.2 2 23 639 660 638 660 0.96

11 15 9.2e-06 0.00061 20.0 1.0 1 23 669 691 669 691 0.98

12 15 0.001 0.069 13.6 0.1 3 23 699 719 697 719 0.97

13 15 5.6e-05 0.0037 17.6 0.5 1 23 725 747 725 748 0.95

14 15 0.047 3.1 8.4 0.4 1 23 758 780 758 780 0.97

15 15 0.0005 0.033 14.6 0.8 1 23 1255 1277 1255 1277 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.7e-05	0.0018	18.6	1.0	1	23	152	174	152	174	0.97
2	15	0.00084	0.055	13.9	1.2	3	23	182	202	180	202	0.94
3	15	9.1e-05	0.006	16.9	0.1	1	23	377	399	377	399	0.98
4	15	0.00031	0.021	15.2	0.9	1	23	405	427	405	427	0.98
5	15	0.00011	0.0074	16.6	2.3	1	23	459	482	459	482	0.94
6	15	0.72	47	4.7	4.3	1	23	525	547	525	547	0.87
7	15	0.004	0.27	11.7	0.4	1	23	553	576	553	576	0.98
8	15	0.027	1.8	9.2	0.4	3	19	585	601	584	602	0.95
9	15	0.00016	0.01	16.2	5.6	1	23	611	633	611	633	0.97
10	15	0.041	2.7	8.6	1.2	2	23	639	660	638	660	0.96
11	15	9.2e-06	0.00061	20.0	1.0	1	23	669	691	669	691	0.98
12	15	0.001	0.069	13.6	0.1	3	23	699	719	697	719	0.97
13	15	5.6e-05	0.0037	17.6	0.5	1	23	725	747	725	748	0.95
14	15	0.047	3.1	8.4	0.4	1	23	758	780	758	780	0.97
15	15	0.0005	0.033	14.6	0.8	1	23	1255	1277	1255	1277	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGAACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAATCAGAGATGACAGCAGCATATTTGGTCAACGCTGACGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTCATCTTTATGGCACGCGACGGCCAACTGAGCGAAATCATCGCCGCCAATGAAGCAaatggcggcagcagcacagTGCTAATCACGGAGAGCGATGGAAATACCGGTGTCGAGTACGCCGAGTCCTTTGAAGATGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGTGCAGAGCGagTGGAAATTGCCGCTGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGCAACAGAATGAGTATATGGCGATGCGTCCCTATCCCTGTGACTTTTGCAGTCGACGGTTTCGGAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGTCCCCATCTCTGCAAGCTGTGCGGGGCGCGTTTCTCGCGGCGCGCGGAGCTCATCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATCAAATTtgagccacaacagcagctacaacaacagcagcagcagcgacaaattGAGGATCATTTCTATGAGCAGGAATGGCCGCTGTatcaggaacaggaacaggagcaggtcgaggagcagctggagcaggtCGATGAGGaggagcatcagcagcagcagttggaacagcatcagcagctgttgcaacaaTTGGTGGCACCACCAACCGCTGCCCGGGGACGCATCAGTCGCTTAAAGCTCAAGGAGGAGAGTTCGCAATATATTGTGATTGCCTCCGATAAACCGGAGgcggagacggagacagagcTGCCTCAATACATGCATGGCGAGGCGAATTGCGATCAATCActtgccaccaacaacaaccaacttCAATCAACATCCAACAATGAtggtgcaactgctgctgctgatggagcacaggggcaggggcaggcaACGCTGCGTTTTCCCGTGCTCGACGAGAGCAAACCCTTCGTCTGTCAGCAGTGCGGATTGGCTTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAACTACAGTCTACAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCATCGGCGGGCGAGGAGGATACGGCGAGCGAATCGGAAGCGGACCAGCTTTACGGTAATTTCTACTGCGGTGAATGTGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacagcaagCAGCTgcctgcaacaacagctggtaacaacaacaacaacaacagtgtggcaactgcaacagcaacggatGCCGCTGCAGCTCCAActgatgccgatgctgatgatgcCAAAGATGCGCCACATTGTTGCCACACCTGCGGCAAATCATTTCTCAGCGTACTCAAACTGCTCGCCCATACCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTCCTATGCGGTGTCAGTTTCTACGAGGAGCAGGCCATAAAGCGGCACCTGAATACGCGGCATCCGCATGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcaAGGAGTGTCGAGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCACGGGAGAAATGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAACGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCAGATGGACGCACCTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTGTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCGCGCAGCTCGCAACAGATTCATGTGCGCATCCATACGGGTGAAAGGCCATACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGTAAACACGAACGGATCCACACGGGCGAGAAGCCCTATGCCTGCTCCGTCTGTCCGCGTGCCTTCAATCAGCGTGTCGTGTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGTGGCACGTATCATTGCACGGTCTGCTCCGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTaCCGGTCCACGAGGAATTTGGCAGCGACTGGACTACTGCGATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAGCCGCagagccaccaccaccagccaCCAAAAAAGcgaaacgcaaacgcaaagcGCCAAATAAAACCGGCGATGAGCAAAGATTGTGGGATGAGAAATTCCTGCAGCAGGCGAGCAATGGGAACAGCGATGAGGCCTACAAGAGTTTCTTTCAAATGGACTCGCTGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTAATGATGGTGTTGCCACGACCAAGTTGCAGCAGTCGGAGATTAAGGagcaaaaactcaaaactggcaatcgcagcagcaaaagaaggGCAGGCAAATCTGGgggagcagcaggaggaacagcaggagcagtagAAACAGTTGCTGCTTCACGTCCCCGCATGATACACACGGCCAAGTCGCAGCAGACAACGTCAAGGAAATCCCGCACAAGGAGTTATATCACACGCACCAGCAccaacgagcagcagcagcagcatcagcagccagGAGGAGGAGCCAGCCTCATCAAATCGCGCATTGTGGATGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGTTGCACATCAAACAGGAGCAGgaacatcaacagcatcatcagcaacagcagcatcagcagcaacagcagcgagtcCAACTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCGAGCATTGTCCAAGATCTTGAGGAGATATTGCGTAGTCCCCCCAAGCATGAGCGAAACGATCGACGGCTGCGCTTTACCAGCGAATCGTCGACAACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTCATCAAGATCGAGCCAACGTCACCGGATCTACGCGAAATGGTTGAgagccagcagccagccacaCTGCCCACATCCTCCTCCGCCGCTTGCTTAACGGCGGCACGCACTTCCCGCCACGTGCGACAGGTGACTGCCAATGGTTCCAGTTCTATTTCCACTGCCTCTTCCAGGTCCAGTGCCGCTGCCGGCACGCGAGCCGCTGCCAAGCGCAATGCCAGCAAGCAGCTTGCCAAGAAATCCACTTCCAATAACAGCAAAGCCAACTCATCATCGTCATATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcagccaGTGCCAATGGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCAGCGGATGCAGCCGATGCAGCCGCgaaggcggcggcggcagcagccagcaaaacgGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCAATTTTCCAGATCGCTCACAGCTGCTGgaacatatgcacatacacatctaG
Protein Sequence: MNNPNYGGIQWIQQESSAVVDDSESEMTAAYLVNADANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNTGVEYAESFEDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQQQQQQRQIEDHFYEQEWPLYQEQEQEQVEEQLEQVDEEEHQQQQLEQHQQLLQQLVAPPTAARGRISRLKLKEESSQYIVIASDKPEAETETELPQYMHGEANCDQSLATNNNQLQSTSNNDGATAAADGAQGQGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEADQLYGNFYCGECGISFHRQDLLRRHSKQQHSKQLPATTAGNNNNNNSVATATATDAAAAPTDADADDAKDAPHCCHTCGKSFLSVLKLLAHTEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRGIWQRLDYCDLDVENVDELLQEAAAEPPPPATKKAKRKRKAPNKTGDEQRLWDEKFLQQASNGNSDEAYKSFFQMDSLVVVNDQTLQPVNDGVATTKLQQSEIKEQKLKTGNRSSKRRAGKSGGAAGGTAGAVETVAASRPRMIHTAKSQQTTSRKSRTRSYITRTSTNEQQQQHQQPGGGASLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHQQQQHQQQQQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPATLPTSSSAACLTAARTSRHVRQVTANGSSSISTASSRSSAAAGTRAAAKRNASKQLAKKSTSNNSKANSSSSYLSYGVDSYNVGVAASANGSSDVSSGFFSISEVVSAADAADAAAKAAAAAASKTERRTRCFECEMCSSNFPDRSQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -