Dmur003928.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila murphyi
Gene Symbol
zfh1
Assembly
GCA_018904325.1
Location
JAEIFX010001232.1:13919915-13926472[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.5e-05 0.0018 18.5 1.0 1 23 150 172 150 172 0.97
2 15 0.00078 0.054 13.8 1.2 3 23 180 200 178 200 0.94
3 15 8.5e-05 0.0059 16.9 0.1 1 23 374 396 374 396 0.98
4 15 0.00029 0.02 15.2 0.9 1 23 402 424 402 424 0.98
5 15 0.0001 0.0072 16.6 2.3 1 23 456 479 456 479 0.94
6 15 0.67 46 4.6 4.3 1 23 521 543 521 543 0.87
7 15 0.0038 0.26 11.7 0.4 1 23 549 572 549 572 0.98
8 15 0.025 1.7 9.1 0.4 3 19 581 597 580 598 0.95
9 15 0.00015 0.01 16.1 5.6 1 23 607 629 607 629 0.97
10 15 0.038 2.7 8.5 1.2 2 23 635 656 634 656 0.96
11 15 8.7e-06 0.0006 20.0 1.0 1 23 665 687 665 687 0.98
12 15 0.00098 0.068 13.5 0.1 3 23 695 715 693 715 0.97
13 15 5.3e-05 0.0036 17.5 0.5 1 23 721 743 721 744 0.95
14 15 0.044 3.1 8.3 0.4 1 23 754 776 754 776 0.97
15 15 0.00045 0.031 14.6 0.5 1 23 1287 1309 1287 1309 0.98

Sequence Information

Coding Sequence
ATGAACAATCCGAACTATGGCGGCATCCAGTGGATACAGCAGGAAAGTAGCGCCGTCGACAGCGAATCAGAGATGACAGCAGCATATTTGGTCAACGCTGACGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTCATCTTTATGGCACGCGACGGCCAACTGAGCGAAATCATCGCCGCCAATGAGGCAAATGGCGGCAGCAGCACAGTGCTAATCACGGAGAGCGATGGAAATACCGGTGTCGAGTACGCCGAGTCCTTTGAAGATGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGTGCAGAGCGAGTGGAAATTGCCGCTGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGTTGTTGGACATGCAGCAGAATGAGTATATGGCGATGCGTCCCTATCCCTGTGACTTTTGCAGTCGACGGTTTCGGAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGTCCCCATCTATGCAAGCTGTGCGGGGCGCGTTTCTCGCGTCGCGCGGAGCTCATCAGTCATTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNATTGGTGGCACCACCAACCGCTGCCCGGGGACGCATCAGTCGCTTAAAGCTCAAGGAGGAGAGTTCGCAATATATTGTGATTGCCTCTGATAAACCGGAGACGGAGACGGAGTTGCCTCAATACATGCATTGCGAGACGAATTGCGATCAATCACTTGCCACCAACAACAACCAACTCCAATCAACATCCAACAATGATGTTGCAACTGCTGCTGCTGATGGAGCACAGGGGCAGGGGCAGGCAACGCTGCGTTTTCCCGTGCTCGACGAGAGCAAACCCTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAACTACAGTCTACAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCATCGGCGGGCGAGGAGGATACGGCGAGCGAATCGGAAGCGGAACAGCTTTACGGTAATTTCTACTGCGGTGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCGCCACAGCAAACAGCAGCACAGGANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTCCAACTGATGCCGATGCTGATGATGCCAAAGATGCGACACATTGTTGCCACACGTGCGGCAAATCATTTCTCAGCGTACTCAAACTGCTCGCCCATACCGAAATCCACAAACGTTTCCCGCCATTCAAATGTGTCCTGTGCGGTGTCAGTTTCTACGAGGAGCAGGCCATAAAGCGGCACCTGAATACGCGGCATTCGCATGAGCTGAAGCCCAATTCGTGTGTGTTGTGTGGCAAGGAGTGTCGAGATCGGAAGGCGCTGATCAAACATGCTTGGGATCATTCACGGGAGAAGTGCCACTCGTGCTCCAAGTGTGGTAAGAATTTCCACAACAAGGCGCGCCTGAAACGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCAGATGGACGCACCTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCCGGCAAACTGTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCGCGCAGCTCGCAACAGATTCATGTGCGCATCCATACGGGTGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGCAAACACGAACGCATCCACACGGGCGAGAAGCCCTATGCCTGCTCCGTCTGTCCGCGTGCCTTCAATCAGCGTGTCGTGTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGTGGCACGTATCATTGCACGGTCTGCTCCGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTACTGGTCCACGTAAATATAAACGTCGCCGGAAACTGCAGCCGCACGAGATTGCGCACATGCGCGCAGAGCACAAGGCTGGCGGTGGCGAAGGCGAGGAGGAGGATTATGGCAGCGACGTGGACTACTGCGATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAGCCGCAGAGCCACCACCACCAGCCACCAAAAAAGCGAAGCGCAAACGCAAAGCGCCAAATAAAACCGGCGATGAGCAAAGATTGTGGGATGAGAAATTCCTGCAGCAGGCGAGCAATGGGAACAGCGATGAGGCCTACAAGAGTTTCTTTCAAATGGACTCGCTGGTCGTGATCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTAGCCACGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAAAACTCAAAACAGGCAATCGCAGCAGCAAAAGAAGGGCTGGCAAATCTGGGGGAGGAGCAGCAGGAGGAACAGCAGGAGTAGTAGAAGCTGTTGCTGCTCCACGTCCCCGCATGATACACACGGCCAAGTCGCAGCAGACAACGTCAAGGAAATCCCGCACAAGGAGTTATGTCACACGCACCANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCAGGAGGAGGAGCAAGCCTCATCAAATCGCGCATTGTGGATGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGTTGCACATCAAACAGGAGCAGGAACATCAACAGCACCATCAGCAACAGCAACAGCAACACCAACGAATCCAACTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCGAGTATTGTACAAGATCTCGAGGAGATATTGCGTAGTCCCCCTAAGCATGAGCGAAACGATCGACGGCTGCGCTTCATCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTTATCAAGATCGAGCCAACGTCACCGGATCTACGCGAAATGGTTGAGAGCCAGCAGCCAGCCACACTGCCCACATCCTCCCCCGCCGCCTGCTCAACGGCGGCACGCACTTCCCGCCACCTGCGACAGCTGACTGCCAATGGTTCCAGTTCCATTTCCACTGCCACTTCCAGTTCCAGTGCCGCTGCCAGCACGCGAGCCGCTGCCAAGCGCAATGCCAGCAAGCAGCTTGCCAAGAAATCCACTTCCAATAGCAGCAAAGCCAACTCATCATCGTCTTATCTCAGCTATGGTGTCGACTCCTATAATGTGGGCGTGGCAACCAGTGCCAATGGCTCCTCGGATGTCAGTTCCGGTTTCTTTTCCATTTCCGAGGTCGTCTCGGCAGCGGATGCTGCCGATGCAGCTGCGAAGGCGGCGGCGGCAGCAGCCAGCAAAACGGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCATTTTTCCAGATCGCTCTCAGCTGCTGGAACACATGCACATACACATCTAG
Protein Sequence
MNNPNYGGIQWIQQESSAVDSESEMTAAYLVNADANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNTGVEYAESFEDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLVAPPTAARGRISRLKLKEESSQYIVIASDKPETETELPQYMHCETNCDQSLATNNNQLQSTSNNDVATAAADGAQGQGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNFYCGECGISFHRQDLLRRHSKQQHRXXXXXXXXXXXXXXXXXXXXXXXXXXXPTDADADDAKDATHCCHTCGKSFLSVLKLLAHTEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHSHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGGEGEEEDYGSDVDYCDLDVENVDELLQEAAAEPPPPATKKAKRKRKAPNKTGDEQRLWDEKFLQQASNGNSDEAYKSFFQMDSLVVINDQTLQPVDAGVATTKLQQAEIKEQKLKTGNRSSKRRAGKSGGGAAGGTAGVVEAVAAPRPRMIHTAKSQQTTSRKSRTRSYVTRTXXXXXXXXXXXXXXXXXXXGGGASLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHQQQQQQHQRIQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFISESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPATLPTSSPAACSTAARTSRHLRQLTANGSSSISTATSSSSAAASTRAAAKRNASKQLAKKSTSNSSKANSSSSYLSYGVDSYNVGVATSANGSSDVSSGFFSISEVVSAADAADAAAKAAAAAASKTERRTRCFECEMCSSIFPDRSQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00542584;
90% Identity
-
80% Identity
-