Basic Information

Insect: Drosophila melanosoma
Gene Symbol: zfh1
Assembly: GCA_035042045.1
Location: JAWNLY010000054.1:832040-837823[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.7e-05 0.0019 18.5 1.0 1 23 152 174 152 174 0.97

2 15 0.00084 0.057 13.8 1.2 3 23 182 202 180 202 0.94

3 15 9.1e-05 0.0062 16.8 0.1 1 23 389 411 389 411 0.98

4 15 0.00031 0.021 15.2 0.9 1 23 417 439 417 439 0.98

5 15 0.0022 0.15 12.5 4.3 1 20 471 490 471 494 0.89

6 15 0.0084 0.57 10.7 3.0 1 23 541 563 541 563 0.94

7 15 0.0088 0.6 10.6 0.4 1 23 569 592 569 592 0.97

8 15 0.027 1.8 9.1 0.4 3 19 601 617 600 618 0.95

9 15 0.00016 0.011 16.1 5.7 1 23 627 649 627 649 0.97

10 15 0.047 3.2 8.3 0.4 2 23 655 676 654 676 0.96

11 15 9.2e-06 0.00063 20.0 1.0 1 23 685 707 685 707 0.98

12 15 0.001 0.072 13.5 0.1 3 23 715 735 713 735 0.97

13 15 5.6e-05 0.0038 17.5 0.5 1 23 741 763 741 764 0.95

14 15 0.047 3.2 8.3 0.4 1 23 774 796 774 796 0.97

15 15 0.0015 0.11 13.0 0.4 1 23 1316 1338 1316 1338 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.7e-05	0.0019	18.5	1.0	1	23	152	174	152	174	0.97
2	15	0.00084	0.057	13.8	1.2	3	23	182	202	180	202	0.94
3	15	9.1e-05	0.0062	16.8	0.1	1	23	389	411	389	411	0.98
4	15	0.00031	0.021	15.2	0.9	1	23	417	439	417	439	0.98
5	15	0.0022	0.15	12.5	4.3	1	20	471	490	471	494	0.89
6	15	0.0084	0.57	10.7	3.0	1	23	541	563	541	563	0.94
7	15	0.0088	0.6	10.6	0.4	1	23	569	592	569	592	0.97
8	15	0.027	1.8	9.1	0.4	3	19	601	617	600	618	0.95
9	15	0.00016	0.011	16.1	5.7	1	23	627	649	627	649	0.97
10	15	0.047	3.2	8.3	0.4	2	23	655	676	654	676	0.96
11	15	9.2e-06	0.00063	20.0	1.0	1	23	685	707	685	707	0.98
12	15	0.001	0.072	13.5	0.1	3	23	715	735	713	735	0.97
13	15	5.6e-05	0.0038	17.5	0.5	1	23	741	763	741	764	0.95
14	15	0.047	3.2	8.3	0.4	1	23	774	796	774	796	0.97
15	15	0.0015	0.11	13.0	0.4	1	23	1316	1338	1316	1338	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCATCGCCGTTGCCGACGACAGCGAAACAGAGATGACAGCAGCCTATTTGGTCAACGCTGCCGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTCATCTTTATGGCACGCGACGGCCAACTGAGCGAAATCATCGCCGCCAATGAGGCAAatggcggcagcagcacagTGCTAATCACGGAAAGCGACGGAAATAACGGTGTGGAATACGCCGAATCCTTTGACGACGATACCCAAGTCGTCACAGAGGAGATCATCACTGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgtGGAAATTGCGGCGGAACAAATCGCTGGCAATGGCAGCTCGCAGGAGCTGTTGGACATGCAACAGAATGAATATATGGCGATGCGTCCCTATCCCTGTGACTTTTGCAGTCGACGCTTTCGGAAGAAGGCCAGCCTCAACAATCACATGCTGGCGCATCAGAATGATCGTCCCCATCTCTGCAAGTTGTGCGGGGCTCGTTTCTCGCGACGGGCGGAGCTCATCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATTAAATTTGAGCCACTACCGCAGCTGcaacaccatcagcagcagcagcgacaagtGGAGGATCATTTCTATGAGCACGAATGGCCGCTGTatcaggaacaggagcaggaacCAGAGCAAGAGCATGAGCAGGAGCGTGAGCAGGTCGATGAGCAGCTGGAGCAAattgaggagcagcagcagctggagcagcagcagctggagcagcaacagctggagcagcatcagcagctgaTGCAACAATCGGTGGCACCACCCACCGCTGCTCGTGGACGTATCAGTCGCTTGAAGCTCAAAGAGGAACAATATATTGTGATTGCCCCCGATAAACCGGAGACGGAGTTGCCTCAATACATGCATTGTGATGCGAATTGCGATCAATCActtgccaccaacaacaacaacaaccaacttCAAGCAACACCATCCAATgatgttgcaactgcagctgctgctgatggggCACAGGGGCAGGCAACGCTGCGTTTTCCCGTGCTCGACGAGAGCAAACCCTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCTCTCGTCTCCCACATCAAGAATCATCGCGTTGATTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAATTATAGTTTGCAGGAGCATCAGAAAACACATCAGTTCGAGGAGAGCAACTCGGAATACGATCCCGCATCAGCGGGCGAGGAGGATACGGCGAGTGAATCGGAAGCGGAACAGCTTTACGGTGATTTTTACTGCGGCGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCGCCACTGCAAACAGCAGCACAGCAAGCAGctaactgcaacaacagctggtggcaacaacaacagtgtggcagttgcaacagcaacggatGCAGTAggtgtggcagctgcagctgcagctgatgctgacgctgatgctgatgatgccaAAGATGCGCCACATTGTTGCCACACTTGTGGCAAATCATTTCCCAACGTACTCAAACTGCTCGCCCATGCCGAAATCCACAAACGTTTCCCGCCATTCAAATGTGTCCTGTGCGGAGTCAGTTTCTACGAGGAGCAGGCCATCAAGCGGCACCTGAGCACGCGGCATCCGCACGAGCTTAAGCAGAActcgtgtgtgttgtgtggcaaGGAGTGCCGGGATCGGAAGGCGCTGATCAAGCATGCGTGGGATCATTCGCGGGAGAAGTGCCACTCGTGCTCCAAGTGTGGTAAGAATTTCCACAACAAGGGGCGCCTGAAGCGGCACATGGCATCGCATCGCGACAAGTCCGTCGTGTGTGAAGTGTGCCAGGAGGAGTTCCCCGACGGACGCACTTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAAATGTTTCCCTGCCACGAGTGTGGCAAGACCTTTGGGTCGCGCAGCTCGCAGCAGATTCACGTGCGCATCCACACGGGTGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGCAAACACGAGCGCATCCACACCGGCGAGAAGCCCTACGCCTGCTCCGTTTGTCCTCGTGCCTTCAATCAGCGTGTCGTCCTACGGGAACACATCCGATCGCATCATTCGGGTCTGGATGTGGCACTTGGCACCTATCATTGCACGGTCTGCTCGGCGGATTTGAGCTCATCAAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTACTGGTCCACGTAAATACAAACGTCGCCGGAAACTGCAGCCGCATGAAATTGCGCATATGCGCGCCGAGCACAAGGCTGGCGGCGTCGATGGCGAGGCTGGGGAGGAGGACGATTATGTGAGCGACTTGGACTACTGCGATCTAGATGTGGAGAATGTGGATGAGTTGCTGCAGGAGGCAACCGCAGAGTCACCACCACCCGCCAAAAAAGCGAAACGCAAACGCAAAGCTCCAACTAAATCAGGCGATGAGCAACGATTGTGGGATGAGAAATTCCTGCAGCAGGCGAGCAATGGAAACAGCGATGAGGCCTACAAAAGTTTCTTTCAAATGGACTCGCTGGTGGTGGTCAATGATCAAACGTTGCAGCCGGTTGATGCTGGTGCTGCCACCACCAAATTGAAGCAGTCTGAGATTAAGgagcaaaaacttaaaacaggcagccgcagcagcaaaagaaggGCTGCCAAAGCTGgcggagcagcaggagcagcaggcggAGGAGCaggtggaggaggagctgctgctgctccacgtCCACGAATGATACACACGGCCAAGTCGCAGCAGACAACTTCAAAGAAATCCCGAACAAGGAGTTATATCACACGCACCAGCACCaatgatcagcagcagcagggaggaggaggaggaggatcaAGTGGAGGAAGCCTCATCAAATCGCGCATTGTGGATGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAAATCAGCTCCAGTCCACTGCACATCAAACAGGAGCAggaacatcatcatcatcatcagcagcaacagcagcaccatcatcatcatcataatcagcagcagcagcagcaacgagtTCAGCTGCTCTTTGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACATACGAGAAATATAACCCCAGCATTGTTCAAGATCTCGAGGAGATTTTGCGTAGTCCCCCCAAGCATGAGCGGGACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGTGAGGAGGAGGAACAGCATCTCATCAAGATCGAGCCCACGTCGCCGGATCTCCGCGAAATGGTCGAgagccagcagccagccacACTGCCAGCGTCCTCCTCCGCCTGCTCAACGGCGGCACGCACTTCCCGCCACCTGCGTCAGCTGACTGCAAAAGGTTTTGGTTCCGTTTCCATTTTGACTGCCACTTCCAGTTCCAGTGCCACTACCAGCACGCGATCCGCTTCCAAGCGCAATGCCAGCAAACAGCTTTCCAAGAAATCCActtccaacagcaacaagggcAACTCATCATCTTCTTATCTCAGCTACGGCGTCGACTCTTACAATGTGGGCGTGGCGGCCAGTGCCACCAGCTCCTCGGATGTCAGTTCCGGTTTCTTTTCCATCTCCGAGGTCGTCTCGGCGGCAGATGCAGCGGATGCAGCTGCAaaggcggcggcagcagccagcaaaacGGAGCGAAAAACGCGTTGTTTTGAGTGCGAAATGTGCTCGTCCAATTTTCCAGATCGTGCCCAGCTGCTGgaacacatgcatatacacatCTAG
Protein Sequence: MNNPDYGGIQWIQQESIAVADDSETEMTAAYLVNAAANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNNGVEYAESFDDDTQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPLPQLQHHQQQQRQVEDHFYEHEWPLYQEQEQEPEQEHEQEREQVDEQLEQIEEQQQLEQQQLEQQQLEQHQQLMQQSVAPPTAARGRISRLKLKEEQYIVIAPDKPETELPQYMHCDANCDQSLATNNNNNQLQATPSNDVATAAAADGAQGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGDFYCGECGISFHRQDLLRRHCKQQHSKQLTATTAGGNNNSVAVATATDAVGVAAAAAADADADADDAKDAPHCCHTCGKSFPNVLKLLAHAEIHKRFPPFKCVLCGVSFYEEQAIKRHLSTRHPHELKQNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKGRLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKMFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVALGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGVDGEAGEEDDYVSDLDYCDLDVENVDELLQEATAESPPPAKKAKRKRKAPTKSGDEQRLWDEKFLQQASNGNSDEAYKSFFQMDSLVVVNDQTLQPVDAGAATTKLKQSEIKEQKLKTGSRSSKRRAAKAGGAAGAAGGGAGGGGAAAAPRPRMIHTAKSQQTTSKKSRTRSYITRTSTNDQQQQGGGGGGSSGGSLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHHHHHQQQQQHHHHHHNQQQQQQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERDDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPATLPASSSACSTAARTSRHLRQLTAKGFGSVSILTATSSSSATTSTRSASKRNASKQLSKKSTSNSNKGNSSSSYLSYGVDSYNVGVAASATSSSDVSSGFFSISEVVSAADAADAAAKAAAAASKTERKTRCFECEMCSSNFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499020;
80% Identity: -