Basic Information

Insect: Drosophila incognita
Gene Symbol: zfh1
Assembly: GCA_035042225.1
Location: JAWNLQ010000224.1:96038-100825[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.3e-05 0.0015 18.9 1.3 1 23 152 174 152 174 0.97

2 15 0.00095 0.062 13.8 1.2 3 23 182 202 180 202 0.94

3 15 0.0001 0.0068 16.9 0.1 1 23 379 401 379 401 0.98

4 15 0.00036 0.023 15.2 0.9 1 23 407 429 407 429 0.98

5 15 0.00013 0.0083 16.6 2.3 1 23 461 484 461 484 0.94

6 15 0.026 1.7 9.3 1.5 1 23 531 553 531 553 0.93

7 15 0.0028 0.18 12.4 0.4 1 23 559 582 559 582 0.98

8 15 0.03 2 9.1 0.4 3 19 591 607 590 608 0.95

9 15 0.00018 0.012 16.1 5.6 1 23 617 639 617 639 0.97

10 15 0.047 3.1 8.5 1.2 2 23 645 666 644 666 0.96

11 15 1e-05 0.00069 20.0 1.0 1 23 675 697 675 697 0.98

12 15 0.0012 0.078 13.5 0.1 3 23 705 725 703 725 0.97

13 15 6.4e-05 0.0042 17.5 0.5 1 23 731 753 731 754 0.95

14 15 0.054 3.5 8.3 0.4 1 23 764 786 764 786 0.97

15 15 0.0039 0.26 11.9 0.5 1 23 1296 1318 1296 1318 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.3e-05	0.0015	18.9	1.3	1	23	152	174	152	174	0.97
2	15	0.00095	0.062	13.8	1.2	3	23	182	202	180	202	0.94
3	15	0.0001	0.0068	16.9	0.1	1	23	379	401	379	401	0.98
4	15	0.00036	0.023	15.2	0.9	1	23	407	429	407	429	0.98
5	15	0.00013	0.0083	16.6	2.3	1	23	461	484	461	484	0.94
6	15	0.026	1.7	9.3	1.5	1	23	531	553	531	553	0.93
7	15	0.0028	0.18	12.4	0.4	1	23	559	582	559	582	0.98
8	15	0.03	2	9.1	0.4	3	19	591	607	590	608	0.95
9	15	0.00018	0.012	16.1	5.6	1	23	617	639	617	639	0.97
10	15	0.047	3.1	8.5	1.2	2	23	645	666	644	666	0.96
11	15	1e-05	0.00069	20.0	1.0	1	23	675	697	675	697	0.98
12	15	0.0012	0.078	13.5	0.1	3	23	705	725	703	725	0.97
13	15	6.4e-05	0.0042	17.5	0.5	1	23	731	753	731	754	0.95
14	15	0.054	3.5	8.3	0.4	1	23	764	786	764	786	0.97
15	15	0.0039	0.26	11.9	0.5	1	23	1296	1318	1296	1318	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAAGCAGAGATGACAGCAGCCTATTTGGTCAACGCTGCCGCCAATGGAAGCATTTCCAACGATGACGAGCTCGATCATATTGCAGCCGAGAATCTCATCTTTATGGCGCGCGACCGCCAACTGAGCGAAATCATCGCCGCAAGTGAGGCAAATGGCGGCAGCACCACAGTGCTAATCACGGAGAGAGACGGAAATAACGGAGTGGAATACGCCGAGTCCTTTGACGATGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgTGGAAATTGCAGCAGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGcaacagaatatatatatttcgatgcGTCCATATCCCTGTGACTTTTGCAGTCGACGCTTTCGCAAGAAGGCCAGCCTCAACAATCATATGCAGGCGCATCAGAACGATCGTCCCCATCTCTGCAAACTGTGCGGGGCGCGTTTCTCGCGACGTGCGGAGCTCATCAGTCACTTCAAGGCTCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATTAAATTtgagccacaacagcagctgcaatcgctgcaacagcagcagcagcagcagcagcgacaaattGATGATCATTTCTATGAGCAGGAATGGCCGCTGTATCAGGAACATGAACAGGAGCAGatcgaggagcagcagctgcagcagatcgaggagcagcagcagcagcagctggagcagttTCAGCAGCGGTTGCAACATTCGGTTGCACCACCAACCGCTGCTCGTGGACGTATCAGTCGATTGAAACTCAAGGAGGAGAGCTCCCAATATATTGTGATTGCCTCCGATAAACCGGAGGCGGAGTTGCCTCAATACATGCATTGCGAGGCGAATGGCGATCAATCACttgccaccaccaacaacagccaagTCCAATCAACATCATCCAATgatgttgcaactgctgctgctgctgctgctgatggggCAGAGGGGCAGGCAACGCTGCGCTTTCCCGTGCTCGACGAGAGCAAACCGTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCTTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAATTCGGAATATGAGCCCGCATCGGCGGGCGAGGAGGATACGGCGAGTGAATCGGAAGCGGAACAGCTTTACGGTAATTTCTACTGTGGAGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacagcaagcagctggctgcaacaacagctggtggcaacaacaacaacaacagtgtggcaactgcaacagcaacggatGCAATGGGTGCCGCagatgcaactgcaactgatgccgatgctgctgATTCCAAAGATGCGACACATTGTTGCCGCACGTGCGGCAAATCATTTCCCAGCGTACTCAAACTGCTCGCCCATGCCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGAATCAGCTTCTACGAGGAGCAGGCGATAAAGCGGCACCTGAACACGCGGCATCCGCACGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcaAGGAGTGTCGCGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCGCGAGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAGCGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCCGATGGACGCACTTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTCTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCACGCAGCTCGCAGCAGATTCATGTGCGCATCCACACGGGTGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGACGGCGGCACTCTCCGCAAACACGAACGCATCCATACGGGCGAGAAGCCCTATGCGTGCTCCGTCTGCCCGCGTGCCTTCAATCAGCGTGTCGTCTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGTGGCACGTGGCACGTATCATTGCACGGTGTGCTCGGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAGCAGCGACAGCCAATTACTGGCCCACGTAAATACAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCACGCCGAGCACAAggctggcggcggcggcggcgatgGCGAGGCTGGCGAGGAGGAGGATTATGCCAGCGACTTGGACTACTGCCATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAACGGCAGAGCCACCATCACCCGCCAAAAAAGCGAAACGCAAACGCAAAGCGCCAATTAAACCCGGTGATGAGCAAAGATTGTGGGATGAGAAATTCCCGCAGCAGGCGAGCAATGGGAATAGCGATGAGGCCTACAAGAGTTTCTTCCAGATGGACTCAGTGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCTCGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAACACTGAAGACAGGCAATCGCAGTAGCAAAAGAAGGGCAGGTAAAGCTGGGGGAGTTGGAGCAGGCGCaccaggaggaggaggaactgctgctactgctgctccaCGTCCCCGGATGATACACACGGCCAAGTCGCAGCAGACAACGGCAAGGAAATCCCGCACAAGGAGTTATGTCACACGCACCAGCAccaatgagcagcagcagggggaAGGAGCAAGTGGAGGAAGCCTCATCAAATCCCGGATTGTAGATGACTACGAGATCATCTCCCCGGCCACGCAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCaaacaggagcaggaacatcaacagcatcatcatcatcagcatcagcatcatcagcagcagcaccagagAGTCCAGTTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCCAGCATTGTCCAAGATCTCGAAGAGATTTTGCGTAGTCCCCCGAAGCATGAGCGGAACGATCGACGGTTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGgcgaggaggaggaacagCATCTCATCAAGATTGAGCCCACGTCGCCGGATCTCCGCGAAATGGTCGAGagccagcagccagcggcACTGCCCACATCTTCCTCCGCCTGCTCAACGGCAGCACGCACTTCCCGCCACCTGCGACAACTGACTGCCAATGGTTCCAGTTCCATTTCCACTGCCACATCCAGTTCCAGTGGCGCTCCAAGTACGCGAGCCGCTTCCAAGCGCAATGCCAGCAAACAGCTTTCCAAGAAATCCActtccaacagcagcaaaggcaacgCTTCATCGTCTTATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcaaccAGTGCCAATAGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCGGCGGATGCAGCCGATGCAGctgcgacggcggcggcggcagcagccagcagaacGGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCCTCCTATTTCCCAGATCGCGCCCAGCTGCTGGAACACATGCACGTGCACATCTAG
Protein Sequence: MNNPDYGGIQWIQQESSAVVDDSEAEMTAAYLVNAAANGSISNDDELDHIAAENLIFMARDRQLSEIIAASEANGGSTTVLITERDGNNGVEYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNIYISMRPYPCDFCSRRFRKKASLNNHMQAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQSLQQQQQQQQRQIDDHFYEQEWPLYQEHEQEQIEEQQLQQIEEQQQQQLEQFQQRLQHSVAPPTAARGRISRLKLKEESSQYIVIASDKPEAELPQYMHCEANGDQSLATTNNSQVQSTSSNDVATAAAAAADGAEGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYEPASAGEEDTASESEAEQLYGNFYCGECGISFHRQDLLRRHSKQQHSKQLAATTAGGNNNNNSVATATATDAMGAADATATDADAADSKDATHCCRTCGKSFPSVLKLLAHAEIHKRFPPFKCVLCGISFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMHAEHKAGGGGGDGEAGEEEDYASDLDYCHLDVENVDELLQEATAEPPSPAKKAKRKRKAPIKPGDEQRLWDEKFPQQASNGNSDEAYKSFFQMDSVVVVNDQTLQPVDAGVASTKLQQAEIKEQTLKTGNRSSKRRAGKAGGVGAGAPGGGGTAATAAPRPRMIHTAKSQQTTARKSRTRSYVTRTSTNEQQQGEGASGGSLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHHHQHQHHQQQHQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPAALPTSSSACSTAARTSRHLRQLTANGSSSISTATSSSSGAPSTRAASKRNASKQLSKKSTSNSSKGNASSSYLSYGVDSYNVGVATSANSSSDVSSGFFSISEVVSAADAADAAATAAAAAASRTERRTRCFECEMCSSYFPDRAQLLEHMHVHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -