Basic Information

Insect: Drosophila kambysellisi
Gene Symbol: zfh1
Assembly: GCA_035042185.1
Location: JAWNLS010000682.1:70327-75253[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.9e-05 0.002 18.5 1.0 1 23 152 174 152 174 0.97

2 15 0.00089 0.062 13.8 1.2 3 23 182 202 180 202 0.94

3 15 9.7e-05 0.0068 16.9 0.1 1 23 373 395 373 395 0.98

4 15 0.00033 0.023 15.2 0.9 1 23 401 423 401 423 0.98

5 15 0.00012 0.0083 16.6 2.3 1 23 455 478 455 478 0.94

6 15 0.012 0.82 10.3 3.0 1 23 526 548 526 548 0.94

7 15 0.00071 0.05 14.1 0.4 1 23 554 577 554 577 0.98

8 15 0.028 2 9.1 0.4 3 19 586 602 585 603 0.95

9 15 0.00017 0.012 16.1 5.6 1 23 612 634 612 634 0.97

10 15 0.044 3.1 8.5 1.2 2 23 640 661 639 661 0.96

11 15 9.8e-06 0.00069 20.0 1.0 1 23 670 692 670 692 0.98

12 15 0.0011 0.078 13.5 0.1 3 23 700 720 698 720 0.97

13 15 6e-05 0.0042 17.5 0.5 1 23 726 748 726 749 0.95

14 15 0.05 3.5 8.3 0.4 1 23 759 781 759 781 0.97

15 15 0.00029 0.02 15.4 0.5 1 23 1297 1319 1297 1319 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.9e-05	0.002	18.5	1.0	1	23	152	174	152	174	0.97
2	15	0.00089	0.062	13.8	1.2	3	23	182	202	180	202	0.94
3	15	9.7e-05	0.0068	16.9	0.1	1	23	373	395	373	395	0.98
4	15	0.00033	0.023	15.2	0.9	1	23	401	423	401	423	0.98
5	15	0.00012	0.0083	16.6	2.3	1	23	455	478	455	478	0.94
6	15	0.012	0.82	10.3	3.0	1	23	526	548	526	548	0.94
7	15	0.00071	0.05	14.1	0.4	1	23	554	577	554	577	0.98
8	15	0.028	2	9.1	0.4	3	19	586	602	585	603	0.95
9	15	0.00017	0.012	16.1	5.6	1	23	612	634	612	634	0.97
10	15	0.044	3.1	8.5	1.2	2	23	640	661	639	661	0.96
11	15	9.8e-06	0.00069	20.0	1.0	1	23	670	692	670	692	0.98
12	15	0.0011	0.078	13.5	0.1	3	23	700	720	698	720	0.97
13	15	6e-05	0.0042	17.5	0.5	1	23	726	748	726	749	0.95
14	15	0.05	3.5	8.3	0.4	1	23	759	781	759	781	0.97
15	15	0.00029	0.02	15.4	0.5	1	23	1297	1319	1297	1319	0.97

Sequence Information

Coding Sequence: ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCATGAAAGCAGCGCCGTCGTCGACGACAGCGAAACAGAGATGACACCAGACTATTTGGTCAACGCTGCCGCGAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTCATCTTTATGGCACGCGACGGCCAACTGAGCGAAATCATCGCCGCAAATGAGGCAaatggcggcagcagcacagTGCTAATCACGGAGAGTGATGGAAATAACGGTGTGGAATACGCGGAGTCCTTTGACGATGATGCTCAGGTCGTCACCGAGGAGATTATCACAGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgTGGAAATTGCCGCTGAGCAAATCGCTGGCAATGGCAGCTCCCAGGAGCTGTTGGACATGCAACAGAATGAATATATGGCGATGCGCCCATATCCCTGCGACTTTTGCAGTCGACGCTTTCGCAAGAAGGCCAGTCTGAACAATCATATGCTTGCGCATCAGAATGATCGTCCGCATCTTTGCAAGCTGTGTGGGGCGCGTTTCTCGCGACGCGCGGAGCTCATCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCTGCCATTAAATTTgagccacaacagcagctgcaacagcagcagcaacagcgacaaatCGAGGATCATTTCTATGAGCATGAATGGCCGCTGTATCAGGAACAAGAGCAGCCGCAGGAGCTGGAACAGGTCgaggagcagctggagcagatcgagaaacagcaacagcagcaactggagcatcatcagcagctgttgcaacaacCACCAACTGCTGCCCGAGGACGCATCAGTCGCTTAAAGCTCAAGGAGGAGAGCTCGCAATACATTGTGATTGCCTCCGATAATCCGGAGACGGAGTTGCCTCAATACTTGCATAGCGAGGCGAATTGCGATCAATCActtgccaccaacaacaaccaactcCAATCAACATCATCCGAtgatgctgcaactgctgctgctgctgctgccgatggGTCACAGGGGCACGCATCACTGCGCTTTCCCGTGCTCGACGAGAGCAAACCCTTTGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGTGTGGATTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTTGAGGAGAGCAATTCGGAATACGATCCGGCATCGGCGGGCGAGGAGGATACGGCGAGTGAATCGGAAGCGGAACAGCTTTACGGTGTTTTCTACTGCGGCGAATGCGGCATCTCCTTTCACCGGCAGGATTTGCTGCGGCgccacagcaaacagcagcacagCAAGCAGCTGGCTGCAGCAACGActggtggcaacaacaacaacaacaacagtgtggcaactgcaacagcaacggatGCAGTaggtgctgcagctgcaactgatgccgatgccgatgctgatGATGCCAAAGATGCGCCACATTGTTGCCACACGTGCGGCAAATCATTTCCCAGCGTACTCAAACTGCTCGCCCATGCCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTCCTGTGCGGAGTCAGCTTCTACGATGAGCAGGCGATAAAGCGGCACCTGAACACGCGGCATCCGCACGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcaAGGAGTGTCGCGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCGCGGGAGAAATGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAGCGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCCGATGGACGCACCTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTGTTCCCATGCCACGAGTGTGGCAAGACTTTTGGGTCTCGCAGCTCGCAGCAGATTCATGTGCGCATCCACACGGGCGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGCAAACACGAACGCATCCACACGGGCGAGAAGCCCTATGCCTGCTCCGTCTGTCCGCGTGCTTTCAACCAGCGTGTCGTCTTGCGGGAACACATCCGCTCGCATCACTCCGGTCTGGATGCGGCACGTGGCACGTACCATTGCACAGTCTGCTCCGCGGATTTGAGTTCATCGAATGACCTCATACAGCACCTCATCCAGCACAGTGATACGAATACAGCCAAACAGCGACAGCCAATTACTGGTCCACGTAAATACAAACGACGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCGTGCCGAGCACAAGgctggtggcggcggcgatGGCGAGGCTTGCGAGGAGGAGGATTATGGCAGCGACTTGGACTACTGCGATTTGGATGTGGAGAATGTGGATGAGTTGCTGCAGGAGGCAACCGCAGAGCCGCCACCACCCACCAAAAAAGCGAAACGCAAACGCAAAGCGCCAACTAAAAGCGGCGATGAGCAAAGATTGTGGGACGAGAAATTACTGCAGCAGGCGAACAATGGGAATAGCGATGAGGCGTACAAGAGTTTCTTTCAAATGGACTCGCTGGTCGTGGTCAATGATCAAACGCTGCAACCCGTTGATGCTGGTGTTGCCGCGACCAAGTTGCAGCAGGCGGATATTAAGGAGCAAACTCTGAAGACAGGCAAtcgcagcagcaaaagaaggGCAGGCAAAGTTagtgcaggagcagcagccggaGGAGGAATAGCAGGCGGAGGAGCATCAGGaggaactgctgctgctccacgtCCCCGTATGATACATACGGCCAAATCGCAGCAGACAACGTCAAGGAAGTCCCGCACAAGGAGGTCTATCACACGCACCAGCACCAATGAGAAGCAGCAGGGGGAAGGAGCAAGTGGAGGAAGCCTTATCAAATCCCGCATTGTGGATGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAGATCAGTTCCAGTCCGCTGCACATCaaacaggagcaggaacatcaacagcatcatcatcatcaccatcaacagcagcagcagcatcagcagcagcagcgagtccAACTGCTCTTCGATGACAGCCATCTGCTCATTGAATCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCCAGCATTGTTCAAGATCTCGAGGAGATTTTGCGTAGTCCCCCGAAGCATGAGCGGAACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTCCCCGGAGAGGAGGAGGAACAGCATCTCATCAAGATCGAGCCCACATCGCCGGATCTCCGGGAAATGGTCGAgagccagcagccagccacACTGCCCACATCCTCCTCCGTCTGTTCAACGGCGGCACGCACTTCCCGCCACCTGCGACAACTGACTGCCAATGGTCCTCCCAGTTCCATTTCCACTGTCACTTCTAGTTCCAGTGCCGCTTCCAGTACGCGAGCCGCTTCCAAGCGCAATGCCAGCAAACAACTTTCCAAGAAATCCACTTCCAATAGCAACAAGGGCAACTCCTCAACGTCTTATCTCAGCTATGGCGTCGACTCCTataatgtgggcgtggcagccagTGCCAACAGCTCCTCAGATGTCAGTTCAGGTTTCTTCTCAATTTCCGAGGTCGTCTCGGCGGCGGATGCAGCCGATGCAGCTGCgaaggcggcggcggcagcagcctGCAAAACGGAGCGAAGAACGCGCTGCTATGAGTGTGAAATGTGCTCCTACAATTTTCCAGATCGTGCCCAGCTGCTGGAACACATGCATGAACACATCTAG
Protein Sequence: MNNPDYGGIQWIQHESSAVVDDSETEMTPDYLVNAAANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNNGVEYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQQQQQQRQIEDHFYEHEWPLYQEQEQPQELEQVEEQLEQIEKQQQQQLEHHQQLLQQPPTAARGRISRLKLKEESSQYIVIASDNPETELPQYLHSEANCDQSLATNNNQLQSTSSDDAATAAAAAADGSQGHASLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGVFYCGECGISFHRQDLLRRHSKQQHSKQLAAATTGGNNNNNNSVATATATDAVGAAAATDADADADDAKDAPHCCHTCGKSFPSVLKLLAHAEIHKRFPPFKCVLCGVSFYDEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGGGDGEACEEEDYGSDLDYCDLDVENVDELLQEATAEPPPPTKKAKRKRKAPTKSGDEQRLWDEKLLQQANNGNSDEAYKSFFQMDSLVVVNDQTLQPVDAGVAATKLQQADIKEQTLKTGNRSSKRRAGKVSAGAAAGGGIAGGGASGGTAAAPRPRMIHTAKSQQTTSRKSRTRRSITRTSTNEKQQGEGASGGSLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHHHHHQQQQQHQQQQRVQLLFDDSHLLIESGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPATLPTSSSVCSTAARTSRHLRQLTANGPPSSISTVTSSSSAASSTRAASKRNASKQLSKKSTSNSNKGNSSTSYLSYGVDSYNVGVAASANSSSDVSSGFFSISEVVSAADAADAAAKAAAAAACKTERRTRCYECEMCSYNFPDRAQLLEHMHEHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -