Dpul013689.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila pullipes
Gene Symbol
zfh1
Assembly
GCA_035043795.1
Location
JAWNMT010000656.1:6264373-6270223[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.8e-05 0.0018 18.5 1.0 1 23 152 174 152 174 0.97
2 15 0.00086 0.054 13.8 1.2 3 23 182 202 180 202 0.94
3 15 9.3e-05 0.0059 16.9 0.1 1 23 380 402 380 402 0.98
4 15 0.00032 0.02 15.2 0.9 1 23 408 430 408 430 0.98
5 15 0.00011 0.0073 16.6 2.3 1 23 462 485 462 485 0.94
6 15 0.74 47 4.6 4.3 1 23 529 551 529 551 0.87
7 15 0.0041 0.26 11.7 0.4 1 23 557 580 557 580 0.98
8 15 0.027 1.7 9.1 0.4 3 19 589 605 588 606 0.95
9 15 0.00016 0.01 16.1 5.6 1 23 615 637 615 637 0.97
10 15 0.042 2.7 8.5 1.2 2 23 643 664 642 664 0.96
11 15 9.5e-06 0.0006 20.0 1.0 1 23 673 695 673 695 0.98
12 15 0.0011 0.068 13.5 0.1 3 23 703 723 701 723 0.97
13 15 5.8e-05 0.0036 17.5 0.5 1 23 729 751 729 752 0.95
14 15 0.049 3.1 8.3 0.4 1 23 762 784 762 784 0.97
15 15 0.00052 0.033 14.5 0.8 1 23 1293 1315 1293 1315 0.98

Sequence Information

Coding Sequence
ATGAACAATCCGAACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAATCAGAGATGACAGCAGCATATTTGGTCAACGCTGACGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTCATCTTTATGGCACGCGACGGCCAACTGAGCGAAATCATCGCTGCCAATGAGGCAaatggcggcagcagcacagTGCTAATCACGGAGAGCGATGGAAATACCGGTGTCGAGTACGCCGAGTCCTTTGAAGATGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTACAGCATCAGGGTGCAGAGAGagTGGAAATTGCCGCTGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTATTGGACATGCAACAGAATGAGTATATGGCGATGCGTCCCTATCCCTGTGACTTTTGCAGTCGACGGTTTCGGAAGAAGGCCAGCCTCAACAATCATATGCTGGCGCATCAGAATGATCGTCCACATCTCTGCAAGCTGTGCGGGGCGCGTTTCTCGCGTCGCGCGGAGCTCATCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATCAAATTtgagccacaacagcagctacaacaacagcagcagcagcagcagcgacaaattGAGGATCATTTCTATGAGCAGGAATGGTCGCTGTATCAGGAtcaggaacaggagcagcagcaggtcgACGATCAGCTGGAGCAGAtcgaggaggagcagcagcagcagcagttggaacagcatcagcagctttTGCAACAATTGGTGGCACCACCAACCGCTGCCCGGGGACGCACCAGTCGCTTAAAGCTCAAGGAGGAGAGTTCGCAATATATTGTGATTGGCTCCGATAAACCGGAggcggagacggagacggagttGCCTCAATACATGCATTGCGAGGCGAATTGCGATCAATCActtgccaccaacaacaaccaactcCAATCAACATCCAACAATGATGTTGCAACTACTGCTAATGATGGGGCACAGGGGCAAGGGCAGGCAACGCTGCGTTTTCCCGTGCTCGACGAGAGCAAACCCTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCACCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAACTACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAACTCGGAATATGATCCGGCATCGGCGGGCGAGGAGGATACAGCGAGCGAATCGGAGGCGGACCAGCTTTACGGTAATTTCTACTGCGGTGAATGTGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacagcaaGCATCTgcctgcaacaacagctggtaacaacaacaataacaacaacagtgtggcaactgcaacagcaacagatgcCGCTGCAGCTCCAAGtgatgccgatgctgatgatgcCAAAGATGCGCTACATTGTTGCCACACCTGCGGCAAATCATTTCTCAGCGTACTCAAACTGCTCGCCCATACCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTCCTGTGCGGTGTCAGTTTCTACGAGGAGCAGGCCATAAAGCGGCACCTGAATACGCGGCATCCGCATGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcaAGGAGTGTCGAGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCACGGGAGAAGTGTCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAACGACACATGGCATCGCATCGCGACAAGTCCGTCGTATGCGAAGTGTGCCATGAGGAGTTCCCAGATGGACGCACCTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTGTTCCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCGCGCAGCTCGCAACAGATTCATGTGCGCATCCATACGGGTGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGATGGTGGCACTCTCCGCAAACACGAACGCATCCACACGGGCGAGAAGCCCTATGCCTGCTCCGTCTGTCCGCGTGCCTTTAATCAGCGTGTCGTGTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGTGGCACGTATCATTGCACGGTCTGCTCCGCAGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACAAACACAGCCAAACAGCGACAGCCAATTaCCGGTCCACGTAAATATAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCGCGCAGAGCACAAGGCTGGCGGTGGTGAAGGCGAGGAGGAGGATTATGGCAGCGACTTGGACTACTGCGATCTGGATGTAGAGAATGTGGATGAACTGTTGCAGGAGGCAGCCGCagagccaccaccaccagccaCCAAAAAAGcgaaacgcaaacgcaaagcGCCAAATAAAACCGGCGATGAGCAAAGATTGTGGGATGAGAAATTCATGCAGCAGGCGAGCAATGGGAACAGCGATGAGGCCTACAAGAGTTTCTTTCAAATGGACTCGCTGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCACGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAAAACTCAAAACaggcagtcgcagcagcaaaagaaggGCAGGCAAATCTGGgggaggagcagcaggaggaacAGCAGGAGTAGTAgaaactgttgctgctccacGTCCCCGCATGATACACACAGCCAAGTCGCAGCAGACAACGCCAAGGAAATCCCGCACAAGGAGTTATGTCACACGCACCAGCacaaatgagcagcagcagcagcatcagcagccaggaggaggaggagcaagcCTCATCAAATCGCGCATTGTGGATGACTACGAGATCATCTCACCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGTTGCACATCAAACAGGAGCAGgaacatcaacagcatcatcagcaacagcagcagcaacagcaacaccaacgaGTTCAACTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGCGAGAAGACCTATGAGAAATATAATCCGAGCATTGTCCAAGATCTCGAGGAGATATTGCGTAGTCCCCCTAAGCATGAGCGAAACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGCGAGGAGGAGGAACAGCATCTCATCAAGATCGAGCCAACGTCACCGGATCTACGCGAAATAATCGAgagccagcagccagccacaCTGCCCACATCCTCCTCTGCCGCCTGCTCAACGGCGGCCCGCACTTCCCGCCACCTGCGACAGCTGACTGCCAATGGTTCCAGTTCCCTTTCCACTGCCacttccagttccagtttcagTGCCGCTGCCAGCACGCGAGCCGCTGCCAAGCGCAATGCCAGCAAGCAGCGTGCCAAGAAATCCACATCCAATAGCAGCAAAGCCAACTCATCATCGTCTTATCTCAGTTATGGCGTCGACTCCTAtaatgtgggcgtggcagccaGTTCCAATGGCTCCTCGGATGTCACTTCCGgtttcttttccatttccgAAGTCGTCTCGGCAGCGGATGCAGCCGATGCAGCTGCgaaggcggcggcggcagcagctagCAAAACGGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCAATTTTCCAGATCGCTCACAGCTGCTGgaacacatgcacatacacatctaG
Protein Sequence
MNNPNYGGIQWIQQESSAVVDDSESEMTAAYLVNADANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNTGVEYAESFEDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQQQQQQQQRQIEDHFYEQEWSLYQDQEQEQQQVDDQLEQIEEEQQQQQLEQHQQLLQQLVAPPTAARGRTSRLKLKEESSQYIVIGSDKPEAETETELPQYMHCEANCDQSLATNNNQLQSTSNNDVATTANDGAQGQGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEADQLYGNFYCGECGISFHRQDLLRRHSKQQHSKHLPATTAGNNNNNNNSVATATATDAAAAPSDADADDAKDALHCCHTCGKSFLSVLKLLAHTEIHKRFPPFKCVLCGVSFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAEHKAGGGEGEEEDYGSDLDYCDLDVENVDELLQEAAAEPPPPATKKAKRKRKAPNKTGDEQRLWDEKFMQQASNGNSDEAYKSFFQMDSLVVVNDQTLQPVDAGVATTKLQQAEIKEQKLKTGSRSSKRRAGKSGGGAAGGTAGVVETVAAPRPRMIHTAKSQQTTPRKSRTRSYVTRTSTNEQQQQHQQPGGGGASLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHQQQQQQQQHQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREIIESQQPATLPTSSSAACSTAARTSRHLRQLTANGSSSLSTATSSSSFSAAASTRAAAKRNASKQRAKKSTSNSSKANSSSSYLSYGVDSYNVGVAASSNGSSDVTSGFFSISEVVSAADAADAAAKAAAAAASKTERRTRCFECEMCSSNFPDRSQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00542584;
90% Identity
iTF_00499722;
80% Identity
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