Basic Information

Gene Symbol
zfh1
Assembly
GCA_035043295.1
Location
JAWNNA010000255.1:852307-857080[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.4e-05 0.0015 18.9 1.3 1 23 152 174 152 174 0.97
2 15 0.00098 0.062 13.8 1.2 3 23 182 202 180 202 0.94
3 15 0.00011 0.0067 16.9 0.1 1 23 380 402 380 402 0.98
4 15 0.00037 0.023 15.2 0.9 1 23 408 430 408 430 0.98
5 15 0.00013 0.0083 16.6 2.3 1 23 462 485 462 485 0.94
6 15 0.027 1.7 9.3 1.5 1 23 533 555 533 555 0.93
7 15 0.0029 0.18 12.4 0.4 1 23 561 584 561 584 0.98
8 15 0.031 2 9.1 0.4 3 19 593 609 592 610 0.95
9 15 0.00019 0.012 16.1 5.6 1 23 619 641 619 641 0.97
10 15 0.048 3 8.5 1.2 2 23 647 668 646 668 0.96
11 15 1.1e-05 0.00069 20.0 1.0 1 23 677 699 677 699 0.98
12 15 0.0012 0.078 13.5 0.1 3 23 707 727 705 727 0.97
13 15 6.6e-05 0.0042 17.5 0.5 1 23 733 755 733 756 0.95
14 15 0.056 3.5 8.3 0.4 1 23 766 788 766 788 0.97
15 15 0.004 0.25 11.9 0.5 1 23 1299 1321 1299 1321 0.98

Sequence Information

Coding Sequence
ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAAGCAGAGATGACAGCAGCCTATTTGGTCAACGCTGCCGCCAATGGAAGCATTTCCAACGATGACGAGCTCGATCATATTGCAGCCGAGAATCTCATCTTTATGGCACGCGACCGCCAACTGAGCGAAATCATCGCCGCAAGTGAGGCGAATGGCGGCAGCACCACTGTGCTAATCACAGAGAGAGACGGAAATAACGGAGTGGAATACGCCGAGTCCTTTGACGATGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgTGGAAATTGCAGCAGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGcaacagaatatatatatttcgatgcGTCCATATCCCTGTGACTTTTGCAGTCGACGCTTTCGCAAGAAGGCCAGCCTCAACAATCATATGCAGGCGCATCAGAATGATCGTCCCCATCTCTGCAAGCTGTGCGGGGCGCGTTTCTCGCGACGTGCGGAGCTCATCAGTCACTTCAAGGCTCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATTAAATTtgagccacaacagcagctgcaatcgctgcaacagcagcagcagcagcagcggcaaattgATGATCATTTCTATGAGCAGGAATGGCCGCTGTATCAGGAACATGAACAGGAGCAGatcgaggagcagcagctgcagcagatcgaggagcagcagcagcagcagctggaacagTTTCAGCAGCGGTTGCAACATTCGGTTGCACCACCAACCGCTGCTCGTGGACGTATCAGTCGATTGAAACTCAAGGAGGAGAGCTCCCAATATATTGTGATTGCCTCCGATAAACCGGAGGCGGAGTTGCCTCAATACGTGCATTGCGAGGCGAATGGCGATCAATCACttgccaccaccaacaacagccaagTCCAATCAACATCATCCAAtgatgttgcaactgctgctgctgctgctgctgctgctgatggggCAGAGGGGCAGGCAACGCTGCGCTTTCCCGTGCTCGACGAGAGCAAACCGTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCTTTTGAGTGCAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAATTCGGAATATGATCCCGCATCGGCGGGCGAGGAGGATACGGCGAGTGAATCGGAAGCGGAACAGCTGTACGGTAATTTCTACTGTGGGGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacagcaagcagctggctgcaacaacagctggtggcaacaacaacaacaacaacagtgtggcaactgcaacagcaacggaTGCAATGGGTGCCGCagatgcaactgcaactgatgccgatgctgatgaTTCCAAAGATGCGACACATTGTTGCCGCACGTGCGGCAAATCATTTCCCAGCGTACTCAAACTGCTCGCCCATGCCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGAATCAGCTTCTACGAGGAGCAGGCGATAAAGCGGCACCTGAACACGCGGCATCCGCACGAGCTGAAGCCCAAttcgtgtgtgttgtgtggcaAGGAGTGTCGCGATCGGAAGGCGCTGATCAAACATGCGTGGGATCATTCGCGAGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAGCGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCCGATGGACGCACTTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTCTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGTTCACGCAGCTCGCAACAGATTCATGTGCGCATCCACACGGGTGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGACGGCGGCACTCTCCGCAAACACGAACGCATCCATACGGGCGAGAAGCCCTATGCGTGCTCCGTCTGCCCGCGTGCCTTCAATCAGCGTGTCGTCTTGCGGGAACACATCCGGTCGCATCACTCCGGTCTGGATGCGGCACGTGGCACTTATCATTGCACGGTGTGCTCGGCGGATTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAGCAGCGACAGCCAATTACTGGCCCACGTAAATACAAACGTCGCCGGAAACTGCAGCCGCATGAGATTGCGCACATGCACGCTGAGCACAAggctggcggcggcggcggcgatgGCGAGGCTGGCGAGGAGGAGGATTATGCCAGCGACTTGGACTACTGCCATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAACCGCAGAGCCACCATCACCCGCCAAAAAAGCGAAACGCAAACGCAAAGCGCCAATTAAACCCGGGGATGAGCAAAGATTGTGGGATGAGAAGTTCCCGCAGCAGGCGAGCAATGGGAATAGCGATGCGGCCTACAAGAGTATCTTCCAGATGGACTCAGTGGTCGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGGTGTTGCCTCGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAACACCGAAGACAGGCAATCGCAGTAGCAAAAGAAGGGCAGGTAAAGCTGGGGGAGGAGGAGCCGGCGCaccaggaggaggaggagctgctgctactgctgctgctccgcgTCCCCGGATGATACACACGGCCAAGTCGCAGCAGACAACGGCAAGGAAATCCCGCACAAGGAGTTATGTCACACGCACCAGCAccaatgagcagcagcagggggaAGGAGCAAGTGGAGGAAGCCTCATCAAATCCCGGATTGTAGATGACTACGAGATCATCTCCCCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCaaacaggagcaggaacatcaacagcatcatcatcatcagcatcagcatcatcagcagcagcaccagagaGTCCAGTTGCTCTTCGATGACAGCCACCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCCAGCATTGTCCAAGATCTCGAAGAGATTTTGCGTAGTCCGCCGAAGCATGAGCGGAACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCggcgaggaggaggaacagCATCTCATCAAGATCGAGCCCACGTCGCCGGATCTCCGCGAAATGGTCGAGagccagcagccagcggcACTGCCCACATCTTCCTCCGCCTGCTCAACGGCAGCACGCACTTCCCGCCACCTGCGACAACTGACTACCAATGGTTCCAGTTCCATTTCCACTGCCACATCCAGTTCCAGTGGCGCTCCAAGTACGCGAGCCGCTTCCAAGCGCAATGCCAGCAAACAGCTTTCCAAGAAATCCacttccaacagcaacaaaggcaGCGCTTCATCCTCTTATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcaaccAGTGCCAATAGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCGGCGGATGCAGCCgatgcagctgcaacggcggcggcggcagcagccagcagaacGGAGCGAAGAACGCGCTGCTTTGAGTGCGAAATGTGCTCGTCCTATTTCCCAGATCGCGCCCAGCTGCTGGAACACATGCACGTGCACATCTAG
Protein Sequence
MNNPDYGGIQWIQQESSAVVDDSEAEMTAAYLVNAAANGSISNDDELDHIAAENLIFMARDRQLSEIIAASEANGGSTTVLITERDGNNGVEYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNIYISMRPYPCDFCSRRFRKKASLNNHMQAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQSLQQQQQQQRQIDDHFYEQEWPLYQEHEQEQIEEQQLQQIEEQQQQQLEQFQQRLQHSVAPPTAARGRISRLKLKEESSQYIVIASDKPEAELPQYVHCEANGDQSLATTNNSQVQSTSSNDVATAAAAAAAADGAEGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGNFYCGECGISFHRQDLLRRHSKQQHSKQLAATTAGGNNNNNNSVATATATDAMGAADATATDADADDSKDATHCCRTCGKSFPSVLKLLAHAEIHKRFPPFKCVLCGISFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMHAEHKAGGGGGDGEAGEEEDYASDLDYCHLDVENVDELLQEATAEPPSPAKKAKRKRKAPIKPGDEQRLWDEKFPQQASNGNSDAAYKSIFQMDSVVVVNDQTLQPVDAGVASTKLQQAEIKEQTPKTGNRSSKRRAGKAGGGGAGAPGGGGAAATAAAPRPRMIHTAKSQQTTARKSRTRSYVTRTSTNEQQQGEGASGGSLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHHHQHQHHQQQHQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERNDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPAALPTSSSACSTAARTSRHLRQLTTNGSSSISTATSSSSGAPSTRAASKRNASKQLSKKSTSNSNKGSASSSYLSYGVDSYNVGVATSANSSSDVSSGFFSISEVVSAADAADAAATAAAAAASRTERRTRCFECEMCSSYFPDRAQLLEHMHVHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00542584;
90% Identity
iTF_00499722;
80% Identity
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