Basic Information

Insect: Drosophila demipolita
Gene Symbol: zfh1
Assembly: GCA_035042405.1
Location: JAWNLI010000481.1:197279-202834[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.7e-05 0.0019 18.5 1.0 1 23 152 174 152 174 0.97

2 15 0.00083 0.058 13.8 1.2 3 23 182 202 180 202 0.94

3 15 9e-05 0.0063 16.8 0.1 1 23 383 405 383 405 0.98

4 15 0.00099 0.069 13.6 0.9 1 23 411 433 411 433 0.98

5 15 0.00011 0.0077 16.6 2.3 1 23 465 488 465 488 0.94

6 15 0.0083 0.58 10.7 3.0 1 23 543 565 543 565 0.94

7 15 0.0087 0.61 10.6 0.4 1 23 571 594 571 594 0.97

8 15 0.026 1.8 9.1 0.4 3 19 603 619 602 620 0.95

9 15 0.00016 0.011 16.1 5.7 1 23 629 651 629 651 0.97

10 15 0.041 2.8 8.5 1.2 2 23 657 678 656 678 0.96

11 15 9.2e-06 0.00064 20.0 1.0 1 23 687 709 687 709 0.98

12 15 0.001 0.073 13.5 0.1 3 23 717 737 715 737 0.97

13 15 5.6e-05 0.0039 17.5 0.5 1 23 743 765 743 766 0.95

14 15 0.047 3.3 8.3 0.4 1 23 776 798 776 798 0.97

15 15 0.0015 0.11 13.0 0.4 1 23 1315 1337 1315 1337 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.7e-05	0.0019	18.5	1.0	1	23	152	174	152	174	0.97
2	15	0.00083	0.058	13.8	1.2	3	23	182	202	180	202	0.94
3	15	9e-05	0.0063	16.8	0.1	1	23	383	405	383	405	0.98
4	15	0.00099	0.069	13.6	0.9	1	23	411	433	411	433	0.98
5	15	0.00011	0.0077	16.6	2.3	1	23	465	488	465	488	0.94
6	15	0.0083	0.58	10.7	3.0	1	23	543	565	543	565	0.94
7	15	0.0087	0.61	10.6	0.4	1	23	571	594	571	594	0.97
8	15	0.026	1.8	9.1	0.4	3	19	603	619	602	620	0.95
9	15	0.00016	0.011	16.1	5.7	1	23	629	651	629	651	0.97
10	15	0.041	2.8	8.5	1.2	2	23	657	678	656	678	0.96
11	15	9.2e-06	0.00064	20.0	1.0	1	23	687	709	687	709	0.98
12	15	0.001	0.073	13.5	0.1	3	23	717	737	715	737	0.97
13	15	5.6e-05	0.0039	17.5	0.5	1	23	743	765	743	766	0.95
14	15	0.047	3.3	8.3	0.4	1	23	776	798	776	798	0.97
15	15	0.0015	0.11	13.0	0.4	1	23	1315	1337	1315	1337	0.98

Sequence Information

Coding Sequence: ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGCCGACGACAGCGAAACAGAGATGACAGCAGCCTATTTGGTCAACGCTGCCGCCAATGGAAGCATTTCCAACGATGACGATCTCGATCATATGGCAGCCGAGAATCTCATCTTTATGGCACGCGACGGCCAACTGAGCGAAATTATCGCCGCCAATGAGGCAAAtggcggcagcagcacagTCCTAATCACGGAAAGCGACGGAAATAACGGTGTGGAATACGCCGAATCCTTTGACGACGATACCCAAGTCGTCACAGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgtGGAAATTGCGGCGGAACAAATCGCTGGCAATGGCAGCTCGCAGGAGCTGTTGGACATGCAACAGAATGAATATATGGCGATGCGTCCCTATCCCTGTGACTTTTGCAGTCGACGCTTTCGGAAGAAGGCCAGCCTCAACAATCACATGCTGGCGCATCAGAATGATCGTCCCCATCTCTGCAAGCTGTGCGGGGCGCGTTTCTCCCGACGGGCAGAGCTCATCAGTCACTTCAAGGCGCATGCCGAGGCCCAGGTGGCCGCCGATGAAGAGGCTGCTGCGGCAGCCATTAAATTTGAGCCACTACAGCGGCTGcaacaccatcagcagcagcagcagcagcagcgacaaattGAGGATCATTTCTATGAGCACGAATGGCCGCTGTAtcaggaacaggagcaggaacCAGAGCAAGAGCATGAGCCGGAGCGGGAGCAGGTCGAAGAGCAGCTGGAGCAAATTGaggagcagcaccagctggagcagcatcaacagctgATGCAACAATCGGTGGCACCACCCACCGCTGCTCGTGGACGCATCAGTCGCTTGAAGCTCAAAGAGGAACAATATATTGTGATTGCCCCCGATAAACCGGAGACGGAGTTGCGTCAGTACATGCATTGTGATGCGAATTGCGATCAATCActtgccaccaacaacaacaacaacaaccaactcCAAGCAACGCCATCCAATgatgttgcaactgcagctgctgctgatggggCACAGGGGCAGGCAACGTTGCGTTTTCCCGTGCTCGATGAGAGCAAACCCTTTGTCTGTCAGCAGTGCGGACTGGCCTTTGCCCGCGAGAAGGCTCTCGTGTCCCATATCAAGAATCATCGCGTGGATTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTTGGACAGTTATAGTTTGCTGGACCATCAGAAAACACATCAATTCGAGGAGAGCAATTCGGAATACGATCCCGCATCGGCGGGCGAGGAGGATACGGCGAGTGAATCGGAAGCGGAACAGCTTTACGGTGATTTTTACTGCGGCGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGAGGCgccacagcaaacagcagcacagcaagcagctaactgcaacaacagctggtggcaacaacaacagtgtggcaactgcaacagcaacggatgcagtgtgtgtggcagctgtATCTGCAActgatgccgatgccgatgctgatgccgatgctggtgctgatgctgatgatgccaAAGATGCGCCACATTGTTGCCACACCTGTGGCAAATCATTTCCCAACGTACTCAAACTGCTCGCCCATGCCGAAATTCACAAACGTTTCCCGCCATTCAAATGTGTCCTGTGCGGAGTCAGCTTCTACGAGGAGCAGGCCATCAAGCGGCACCTGAGCACGCGGCATCCGCACGAGCTGAAGCAGAActcgtgtgtgttgtgtggcaaGGAGTGCCGGGATCGGAAGGCGCTGATCAAGCATGCATGGGATCATTCGCGGGAGAAGTGCCACTCGTGCTCCAAGTGTGGAAAGAATTTCCACAACAAGGGGCGCCTGAAGCGGCACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGTCACGAAGAGTTCCCCGACGGACGCACTTTGTCCAACCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAAATGTTTCCCTGCCACGAGTGTGGCAAGACCTTTGGGTCGCGCAGCTCGCAGCAGATTCACGTGCGCATCCACACGGGTGAAAGGCCCTACGGTTGTCGGTACTGCTGGAAGGCCTTCGCCGATGGCGGCACTCTCCGCAAACACGAGCGCATCCACACCGGCGAGAAGCCCTACGCCTGCTCCGTCTGTCCGCGTGCCTTCAATCAGCGTGTCGTCCTGCGGGAACACATCCGATCGCATCATTCGGGCCTGGATGTGGCACTTGGCACGTATCATTGCACGGTCTGCTCGGCGGATTTGAGCTCATCAAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGCCAAACAGCGACAGCCAATTACTGGTCCACGTAAATACAAACGTCGCCGGAAACTGCAGCCGCATGAAATTGCGCATATGCGCGCCGAGAACAAGGCTGGCGGCGTCGATGGCGAGGttggggaggaggaggaggattaTGTGAGCGACTTGGACTACTGCGATCTGGATGTGGAGAATGTGGATGAGTTGCTGCAGGAAGCAACCGCAGAGCCGCCACCACCAGCaaccaaaaaagcaaaacgcaaACGCAAAGCTCCAATTAAATCAGGCGATGAGCAAAGATTGTGGGATGAGAAATTCCTGCAGCAGACGAGCAATGGAAACAGCGATGAGGCCTACAAAAGCTTCTTTCAAATGGACTCGCTGGTGGTGGTCAATGATCAAACGTTGCAGCCCGTTGATGCTGCCAAGTTGCAGCAGGCTGAGATTAAGGAGCAAAAGCTGAAAGCaggcagtcgcagcagcaaaagaaggGCTGCAAAAGCTGgcggaggagcaggagcagcaggagcaagtGGAGGaggaactgctgctgctccacgtCCACGCATGATACACACGGCCAAGTCGCAGCAGACAACTTCAAAGAAATCCCGCACAAGGAGTTATATCACACGCACCAGCAccaatgagcagcagcagcagcagggaagaggaggaggagcaagTGGAAGCCTTATCAAATCGCGCATTGTGGATGACTATGAGATCATCTCACCGgccacacacccacccaaTCAAATCAGCTCCAGTCCACTGCACATCAAACAGGAGCAggaacatcatcatcatcatcatcaccatcatcagcagcagcagcagcagcagcagcagcatcatcatcagcagcagcaacgagcTCAGCTGCTCTTTGATGACAGCCATCTGCTCATCGATGCGGGCCTATTGCGTGAGAAGACCTACGAGAAATATAACCCCAGCATTGTTCAAGATCTCGAGGAGATTTTGCGTAGTCCCCCCAAGCATGAGCGGGACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGGTGAAGAGGAGGAACAGCATCTCATCAAGATCGAGCCAACGTCGCCGGATCTCCGCGAAATGGTCGAgagccagcagccagccacACTGCCAGCGTCCTCCTCCGTCTGCTCTACGGCGGCACGCACTTCCCGCCACCGGCGTCAGCTGACTGCTAAAGGTTCCTACTCCGGTTCCATTTTGACTGCCACTTCTAGTTCCAGTGCTACTATCAGCACGCGATCCGCTTCCAAGCGCAATGCCAGCAAACAGCTTTCCAAGAAATCCActtccaacagcaacaagggcAACTCATCATCTTCTTATCTCAACTATGGCGTCGACTCTTACCATGTGGGCGTGGTGGCCAATGCCACTAGCTCCTCGGATGTCAGTTCCGGTTTCTTTTCCATCTCCGAGGTCGTCTCGGCGGCAGATGCAGCGGATGCAGCTGCAaaggcggcggcagcagccagcaaaacGGAGCGAAAAACGCGTTGCTTTGAGTGCGAAATGTGCTCGTCCAATTTTCCAGATCGTGCCCAGCTGCTGgaacacatgcatatacacatCTAG
Protein Sequence: MNNPDYGGIQWIQQESSAVADDSETEMTAAYLVNAAANGSISNDDDLDHMAAENLIFMARDGQLSEIIAANEANGGSSTVLITESDGNNGVEYAESFDDDTQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNEYMAMRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPLQRLQHHQQQQQQQRQIEDHFYEHEWPLYQEQEQEPEQEHEPEREQVEEQLEQIEEQHQLEQHQQLMQQSVAPPTAARGRISRLKLKEEQYIVIAPDKPETELRQYMHCDANCDQSLATNNNNNNQLQATPSNDVATAAAADGAQGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFLDSYSLLDHQKTHQFEESNSEYDPASAGEEDTASESEAEQLYGDFYCGECGISFHRQDLLRRHSKQQHSKQLTATTAGGNNNSVATATATDAVCVAAVSATDADADADADAGADADDAKDAPHCCHTCGKSFPNVLKLLAHAEIHKRFPPFKCVLCGVSFYEEQAIKRHLSTRHPHELKQNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKGRLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKMFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVALGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKAGGVDGEVGEEEEDYVSDLDYCDLDVENVDELLQEATAEPPPPATKKAKRKRKAPIKSGDEQRLWDEKFLQQTSNGNSDEAYKSFFQMDSLVVVNDQTLQPVDAAKLQQAEIKEQKLKAGSRSSKRRAAKAGGGAGAAGASGGGTAAAPRPRMIHTAKSQQTTSKKSRTRSYITRTSTNEQQQQQGRGGGASGSLIKSRIVDDYEIISPATHPPNQISSSPLHIKQEQEHHHHHHHHHQQQQQQQQQHHHQQQQRAQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERDDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPATLPASSSVCSTAARTSRHRRQLTAKGSYSGSILTATSSSSATISTRSASKRNASKQLSKKSTSNSNKGNSSSSYLNYGVDSYHVGVVANATSSSDVSSGFFSISEVVSAADAADAAAKAAAAASKTERKTRCFECEMCSSNFPDRAQLLEHMHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00552462; iTF_00543890; iTF_00511429; iTF_00500461; iTF_00535478;
80% Identity: -