Basic Information

Insect: Drosophila neutralis
Gene Symbol: zfh1
Assembly: GCA_035044385.1
Location: JAWNME010000525.1:97546-102100[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.3e-05 0.0015 18.9 1.3 1 23 152 174 152 174 0.97

2 15 0.00094 0.064 13.8 1.2 3 23 182 202 180 202 0.94

3 15 0.0001 0.007 16.9 0.1 1 23 376 398 376 398 0.98

4 15 0.00035 0.024 15.2 0.9 1 23 404 426 404 426 0.98

5 15 0.00013 0.0086 16.6 2.3 1 23 458 481 458 481 0.94

6 15 0.026 1.8 9.3 1.5 1 23 528 550 528 550 0.93

7 15 0.0028 0.19 12.4 0.4 1 23 556 579 556 579 0.98

8 15 0.03 2 9.1 0.4 3 19 588 604 587 605 0.95

9 15 0.00018 0.012 16.1 5.6 1 23 614 636 614 636 0.97

10 15 0.046 3.1 8.5 1.2 2 23 642 663 641 663 0.96

11 15 1e-05 0.00071 20.0 1.0 1 23 672 694 672 694 0.98

12 15 0.0012 0.08 13.5 0.1 3 23 702 722 700 722 0.97

13 15 6.3e-05 0.0043 17.5 0.5 1 23 728 750 728 751 0.95

14 15 0.053 3.6 8.3 0.4 1 23 761 783 761 783 0.97

15 15 0.0091 0.62 10.8 0.6 1 23 1285 1307 1285 1307 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.3e-05	0.0015	18.9	1.3	1	23	152	174	152	174	0.97
2	15	0.00094	0.064	13.8	1.2	3	23	182	202	180	202	0.94
3	15	0.0001	0.007	16.9	0.1	1	23	376	398	376	398	0.98
4	15	0.00035	0.024	15.2	0.9	1	23	404	426	404	426	0.98
5	15	0.00013	0.0086	16.6	2.3	1	23	458	481	458	481	0.94
6	15	0.026	1.8	9.3	1.5	1	23	528	550	528	550	0.93
7	15	0.0028	0.19	12.4	0.4	1	23	556	579	556	579	0.98
8	15	0.03	2	9.1	0.4	3	19	588	604	587	605	0.95
9	15	0.00018	0.012	16.1	5.6	1	23	614	636	614	636	0.97
10	15	0.046	3.1	8.5	1.2	2	23	642	663	641	663	0.96
11	15	1e-05	0.00071	20.0	1.0	1	23	672	694	672	694	0.98
12	15	0.0012	0.08	13.5	0.1	3	23	702	722	700	722	0.97
13	15	6.3e-05	0.0043	17.5	0.5	1	23	728	750	728	751	0.95
14	15	0.053	3.6	8.3	0.4	1	23	761	783	761	783	0.97
15	15	0.0091	0.62	10.8	0.6	1	23	1285	1307	1285	1307	0.97

Sequence Information

Coding Sequence: ATGAACAATCCGGACTATGGCGGCATCCAGTGGATACAGCAGGAAAGCAGCGCCGTCGTCGACGACAGCGAAGCAGAGATGACAGCAGCCTATTTGGTCAACGCTGCCGCCAATGGAAGCATTTCCAACGATGACGAGCTCGATCATATTGCAGCCGAGAATCTCATCTTTATGGCACGAGACCGCCAACTGAGCGAAATCATCGCCGCAAGTGAGGCAAATGGCGGCAGCACCACAGTGCTAATCACGGAGAGAGACGGAAATAACGGAGTGGAATACGCCGAGTCCTTTGACGATGATGCCCAAGTCGTCACCGAGGAGATCATCACGGATGATTGGGTCCAGCATCAGGGCGCAGAGCGtgTGGAAATTGCAGCAGAGCAAATCGCTGGCAACGGCAGCTCCCAGGAGCTGTTGGACATGCAacagaatatatacatttcgATGCGTCCATATCCCTGTGACTTTTGCAGTCGACGCTTTCGCAAGAAGGCCAGCCTCAACAATCATATGCAGGCGCATCAGAATGATCGTCCCCATCTCTGCAAACTGTGCGGGGCGCGTTTCTCGCGACGTGCGGAGCTCATCAGTCACTTCAAGGCGCATGCGGAGGCCCAGGTGGCCGCCGATGAAGAGGCAGCTGCGGCAGCCATTAAATTtgagccacaacagcagctgcaatcgctgcaacagcagcagcagcagcgacaaattGATGATCATTTCTATGAGCAGGAATGGCCGCTGTATCAGGAACATGAACAGGAGCAGatcgaggagcagcagctgcagcagatcgaggagcagcagcagcagcagctggagcagttTCAGCAGCGGTTGCAACATTCGGTTGCACCACCAACCGCTGCTCGTGGACGTATCAGTCGATTGAAACTCAAGGAGGAGAGCTCCCAATATATTGTGATTGCCTCCGATAAACCGGAGGCGGAGTTGCCTCAATACATGCATTGCGAGGCGAATGGCGATCAATCACttgccaccaacaacagccaagTGCAATCAACATCATCCAATgatgttgcaactgctgctgctgctgctgctgatggggCAGAGGGGCAGGCAACGCTGCGCTTTCCCGTGCTCGACGAGAGCAAACCGTTCGTCTGTCAGCAGTGCGGATTGGCCTTTGCCCGCGAGAAGGCGCTCGTCTCCCACATCAAGAATCATCGCGTGGATTCGCCCTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGACAATTACAGTCTGCAGGAGCATCAGAAGACGCATCAGTTCGAGGAGAGCAATTCGGAATATGAGCCCGCATCGGCGGGCGAGGAGGATACGGCGAGTGAATCGGAAGCGGAACAGCTTTACGGTAATTTCTACTGTGGAGAATGCGGCATCTCCTTTCACCGGCAGGATTTGTTGCGGCgccacagcaaacagcagcacagcaaGCAGCTGGCTGCATCAACAGctggtggcagcaacaacaacaacagtgtggcaactgcaacagcaacggatGCAATGGGTGCCGCagatgcaactgcaactgatgCCGATGCTGGTGATTCCAAAGATGCGACACATTGTTGCCGCACGTGCGGCAAATCATTTCCCAGCGTACTCAAACTGCTCGCCCATGCCGAAATCCACAAACGCTTCCCGCCATTCAAATGTGTGCTGTGCGGAATCAGCTTCTACGAGGAGCAGGCGATAAAGCGGCACCTCAACACGCGGCATCCGCACGAACTGAAGCAAAATtcatgtgtgttgtgtggcaAGGAGTGTCGCGATCGAAAGGCGCTGATCAAACATGCGTGGGATCATTCGCGAGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAATTTCCACAACAAGGCGCGCCTGAAGCGACACATGGCATCGCATCGCGACAAGTCCGTCGTGTGCGAAGTGTGCCACGAGGAGTTCCCCGATGGACGCACTTTGTCCAATCATCGGCATTCCCACAGCACAACGTCGCCGGGCAAACTCTTTCCCTGCCACGAGTGTGGCAAGACTTTTGGGTCACGCAGCTCGCAACAGATTCATGTGCGCATCCACACGGGTGAAAGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTCGCCGACGGCGGCACTCTCCGCAAACACGAACGCATCCATACGGGCGAGAAGCCCTATGCGTGCTCCGTCTGCCCGCGTGCCTTCAATCAGCGTGTGGTCTTGCGGGAACACATCCGGTCGCATCATTCCGGTCTGGATGCGGCACGTGGCACGTATCATTGCACGGTGTGCTCGGCGGACTTGAGCTCATCGAATGACCTCATCCAGCATCTCATCCAGCACAGTGATACGAACACAGccaagcagcggcagccaatTACTGGCCCACGTAAATACAAACGTCGCCGGAAACTGCAGCCGCATGAGATAGCGCACATGCACGCCGAGCACAAGGCTGGCGGCGGCGATGGCGAGGCTGGCGAGGAGGAGGATTATGCCAGCGACTTGGACTACTGCCATCTGGATGTGGAGAATGTGGATGAACTGCTGCAGGAGGCAACCGCAGAGCCACCATCACCCGCCAAAAAAGCGAAACGCAAACGCAAAGCGCCAATTAAAACTGGTGACGAGCAAAGATTGTGGGATGAGAAATTCCCGCAGCAGGCGAGCAATGGGAATAGCGATGAGGCCTACAAGAGTTTCTTCCAGATGGACTCAGTGGTCGTGGACAATGATCAAACGTTGCAGCCcgttggtgctggtgttgccTCGACCAAGTTGCAGCAGGCGGAGATTAAGGAGCAAACACTGAAGGCAGGCAATCGCAGTAGCAAAAGAAGGGCAGGTAAAGCTgggggaggaggagcaggcgcaccaggaggaggaggagctgctgctactgctgctccaCGTCCCCGGATGATACACACGGCCAAGTCGCAGCAAACAACGGCAAGGAAATCCCGCACAAGGAGTTATGTCACACGCACCAGCACCAATGAACAGCAGCAGGGGGAAGGAGCAAGTGGAGGAAGCCTCATCAAATCCCGGATTGTGGATGACTACGAGATCATCTCCCCGGCCACACAGCCACCCAATCAGATCAGCTCCAGTCCGCTGCACATCAAACAGGAGCAggaacatcaacagcatcatcagcatcatcagcagcagcaccagagaGTCCAATTGCTCTTCGATGACAGCCATCTGCTCATCGATGCGGGCCTGTTGCGTGAGAAGACCTACGAGAAATATAATCCCAGCATTGTCCAAGATCTCGAAGAGATTTTGCGTAGTCCCCCGAAGCATGAGCGGGACGATCGACGGCTGCGCTTCACCAGCGAATCGTCGACGACGCCACAATTTCTGCCCGgcgaggaggaggaacagCATCTCATCAAGATCGAACCCACGTCGCCGGATCTCCGCGAAATGGTCGAgagccagcagccagcggcACTGCCCACATCTTCCTCCGCCTGCTCAACGGCAGCACGCACTTCCCGCCACCTGCGACAACTGACTGCCAATGGTTCCAGTTCCATTTCCACTGCCACATCCAGTTCCAGTGGCGCTCCAAGTACGCGCGCCGCTTCCAAGCGCAATGCCAGCAAACAGCTTTCCAAGAAATCCActtccaacagcaacaaaggcaACGCTTCATCGTCTTATCTCAGCTATGGCGTCGACTCCTAtaatgtgggcgtggcaaccAGTGCCAATAGCTCCTCGGATGTCAGTTCCGgtttcttttccatttccgAGGTCGTCTCGGCGGCGGATGCAGCCGATGCAGCTgcaacggcggcggcggcagcagccacGGAGCGAAGAACGCGCTGCTTTGAATGCGAAATGTGCTCGTCCTATTTCCCAGATCGCGCCCAGCTGCTGGAACACATGCACGAACACATCTAG
Protein Sequence: MNNPDYGGIQWIQQESSAVVDDSEAEMTAAYLVNAAANGSISNDDELDHIAAENLIFMARDRQLSEIIAASEANGGSTTVLITERDGNNGVEYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNGSSQELLDMQQNIYISMRPYPCDFCSRRFRKKASLNNHMQAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQVAADEEAAAAAIKFEPQQQLQSLQQQQQQRQIDDHFYEQEWPLYQEHEQEQIEEQQLQQIEEQQQQQLEQFQQRLQHSVAPPTAARGRISRLKLKEESSQYIVIASDKPEAELPQYMHCEANGDQSLATNNSQVQSTSSNDVATAAAAAADGAEGQATLRFPVLDESKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNYSLQEHQKTHQFEESNSEYEPASAGEEDTASESEAEQLYGNFYCGECGISFHRQDLLRRHSKQQHSKQLAASTAGGSNNNNSVATATATDAMGAADATATDADAGDSKDATHCCRTCGKSFPSVLKLLAHAEIHKRFPPFKCVLCGISFYEEQAIKRHLNTRHPHELKQNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAARGTYHCTVCSADLSSSNDLIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMHAEHKAGGGDGEAGEEEDYASDLDYCHLDVENVDELLQEATAEPPSPAKKAKRKRKAPIKTGDEQRLWDEKFPQQASNGNSDEAYKSFFQMDSVVVDNDQTLQPVGAGVASTKLQQAEIKEQTLKAGNRSSKRRAGKAGGGGAGAPGGGGAAATAAPRPRMIHTAKSQQTTARKSRTRSYVTRTSTNEQQQGEGASGGSLIKSRIVDDYEIISPATQPPNQISSSPLHIKQEQEHQQHHQHHQQQHQRVQLLFDDSHLLIDAGLLREKTYEKYNPSIVQDLEEILRSPPKHERDDRRLRFTSESSTTPQFLPGEEEEQHLIKIEPTSPDLREMVESQQPAALPTSSSACSTAARTSRHLRQLTANGSSSISTATSSSSGAPSTRAASKRNASKQLSKKSTSNSNKGNASSSYLSYGVDSYNVGVATSANSSSDVSSGFFSISEVVSAADAADAAATAAAAAATERRTRCFECEMCSSYFPDRAQLLEHMHEHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00542584;
90% Identity: iTF_00499722;
80% Identity: -