Basic Information

Gene Symbol
IKZF1
Assembly
GCA_947568875.1
Location
OX387648.1:9234992-9244558[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 2.9 3.1e+02 3.0 0.9 1 23 54 77 54 77 0.94
2 19 0.08 8.4 7.9 4.1 1 23 84 107 84 107 0.97
3 19 4.6 4.9e+02 2.3 4.0 1 23 193 215 193 215 0.96
4 19 0.0016 0.17 13.2 1.0 2 23 221 242 220 242 0.97
5 19 1.9 2e+02 3.5 1.4 1 23 248 270 248 271 0.94
6 19 0.19 20 6.7 3.4 2 22 505 525 504 525 0.95
7 19 0.079 8.4 7.9 2.6 1 23 622 644 622 644 0.95
8 19 2.9 3.1e+02 3.0 0.3 2 23 781 802 780 802 0.95
9 19 0.001 0.11 13.8 0.5 2 23 882 903 881 903 0.96
10 19 0.12 13 7.3 0.3 1 23 911 933 911 933 0.97
11 19 4.6 4.9e+02 2.3 2.6 1 23 969 991 969 991 0.93
12 19 0.00022 0.023 15.9 4.0 1 23 999 1021 999 1021 0.99
13 19 0.04 4.3 8.8 1.8 1 23 1100 1122 1100 1122 0.99
14 19 0.002 0.22 12.9 1.0 1 23 1292 1314 1292 1314 0.96
15 19 0.0063 0.66 11.4 0.4 1 23 1320 1342 1320 1342 0.96
16 19 0.0062 0.66 11.4 2.6 1 23 1432 1454 1432 1454 0.97
17 19 0.00016 0.016 16.4 1.4 1 23 1460 1482 1460 1482 0.99
18 19 0.77 82 4.8 2.7 1 23 1574 1596 1574 1596 0.96
19 19 0.0091 0.96 10.9 5.6 1 23 1607 1629 1607 1629 0.98

Sequence Information

Coding Sequence
ATGCTACAGCAGATGTCCTCGCCGCCGAGCGCACAAGTCGGCGAGGTCGCGACTATCGTGCGCCACCTTGAAGGCCGCGTCTGCGGCGACGTGTCTTCGGAGGCTTCCTCGGACGCCGCCGAAGATTTTGAATTACCACAGTGCAAGATAAGGAGAAATTATAATTGCACCAAGTGCACGTTCTATACGCAGAACCCGCGCGCTTATCTTGTCCACACACGTGACGCTCACTTCGTCAGACTCAAGATTTACGATTGTCCACACTGTGTTTACGCCTCGAGACATCATCAGAAACTTATAAGACACGTCAAAATGGTTCACGGAGGATCAAAGCCGACTTCTGCGGCCAGTAAAGCAGATGCAGAACTGTCACCTCCCTCCAACGATAACATGGAGCCAGCAGAGCGCATTGAAGACATGCTTGAGGAAGTCGAAGACTGTGAGGATATGATGATGGAAGTAGATGATGACTCCATGGACCAACCTGATGATATCGACGGCGACTGCGATAGAAGTGTTGACTATGCATCGCCCTCTTATCGGAGGGCACATCTGTCAAAAGCTAAGGGCAAATTCTTCTCATGCGATAAGTGCAACTATGTCACCCACATAAGAGCTAGATTCACAAAGCACGTCAAGTATCATTCGATGCCTATGATCAAGTGTACAATGTGTGATTTCCGAACTCCATATAAATGGAATTTGGACCGTCACATGAAGAACCACGGTGGAAGTGGGAGTTTCAACTGTTCGATGTGCAACTTCACGGCGGACATCAAGCAGAGTCTGACGGTGCACGAAATGAATCATCACACACCGCCAGCGGGCCAATCGCTGTCGAGTCGCCGCCGCAACCGGGTGGGCGCCAGCGACACGGTTATCGCGGAGTTCGACGCAGCGAGCACGTTGCTCCCCAAGGAGGAAGAAGGGAGCGGCGACTCGCGGTCCTCACACTCGGTCTCGGACATGGGTCTCCAGTACGCAGAGAGAGAACTAGTCGGTTGCAAAAGTGATTCCAATGACGGTACAGCGTCTGACGCAATCACCAGAAAGGAGACATCGCAAGATGGATACCACCAGCTTTCACCAACTCATAGCGCAGACGAGAAACAACAAAAACAAAGTAGAAAGATTCCCAGACCAATACCACAGCTCATACCTTTAAACTCTTCAACACCCAACCAAAAACAAACATGCTCTGGCGAACCGCCACAGAAAAAGTTCAAGGAATCTTTGCCCATAGACATTGAAGATGTGTCTACTGAAAATACTCTTCTACCAGCAAATCCATCAATAAAAGAGACTGCAGGAGGTCGAAAGAAAAATGAATCATTCTTCGACAAACTAAAAGAAAGACTGCTTACAGAAACAGGCGAAGAAGGCTCACTAATATGTAAGATCTGTGGATTTGAAAGTAAATGTTTATCAGAACATTCTGTCCACGAGAAAAATTGTTCTCCACAAACGAACCGGATCAATGCAAACACGTCGCTTAAAAGTTTAAGTTCCACTCGATGCCAGAATTGCAGACACAGGTGTAAATCTAGCGCCGACTTGTACATCCACATGCAAACTTGCGGAAAGAGCGAAAAGATCGACGATGAAAACAATATCAAAAATGAAAATAGTAGTGATGAAGTCATTCCAATCCATGAAAAAGAGACTGAACCGCACCCAATGGAAAACGTTGTTTTCGTATGGAACAACATTAATCATGACCCTAACAAGTTTGATATACCTTTAGACATAAACATCAATGATGATTCCACTCTACCAGAAATACATCGAAGTTTTGACGCTGAGATTGTTGATGATAATGAAAGCATGAATTTGTCGCCAAGTCAAGCTATTGGAAGGAAGGTATTTAAATGTCCACATTGTCCATTTTTCTCCACAACAGCGTCCAGATTTCACGTTCATATCGTGGGCCATTTAAACAAGAAACCATTTGAGTGTTCCCTCTGCAAATATAAATCTAATTGGAGATGGGATATAACCAAACACATTAAATTGAAATCAGCGAGGGATCCTGAGCATAACGAAGCTAAAGTACTTATGACTGATGAAACAGGAAGAAGAAATTATAGCAAATACAACAAATTTTTAGCAATGCCTGTTTTAAACGAAAATGGCGAAAATGAGTTTCACTACCTGGATCCTAATACTGCAGTCGATAGCACGATGGAAATGGATGAATCATTTAATGATATGTCAGACGTTATGAATGTTCAATTTGAAATGCAACCGCTTAACTTACAGACTCAACACAGTGAAGATAATTACAACTATATTGATAACAGAGGTCTCAATGATATGAAGAAACCCAAGAAAACATTATGGAAATGTAAAAGATGTAATTACAAAGATCCCTCAAGAGAAGCTCTTTTAGAGCATGTTCGTGAACACTCCAGATCGGATGGCATCCATGACGAACTAAACAAACCACCTATTAAGAAACCTGAAAATAATACTCCCGACCCAGCAGACTTGGCGTATCGTTGTGGCCATTGTAACCAATTGTCTAATTGGAAACATGTCATACAGCGCCATTGCCGATTAAAACACGATGGAGTGATCAAAGTGATAACTACAGTTAAACCAAAACCTGACCCACCAATGAACATCAATGAGATAAATATTGATACTTGCAACAAATGCCCGTACAGAACGAGTGACAAGAAACTACTCATTGCCCATTTACAACAGCATCAGCCCTCGCCGAACTCTATTTTCAAGTGCTACTTTTGTCCGTTCTTCGTAAAGGATGAGCCGGAATTAATCCAACATCTACTCCTGCACGGTATCACTGATCCAGAAGATTACATCGCAAAAGCAATGGGAACTAAATCCCCAGGACCAGAACCGCAAGCACCCGTTACTACGACGTTAAACTCCACCAAGCGTCACAAATGCATAGAATGTCCATACGAAACAAATAGTAAGTCACAATTTATGTACCACGAACAATTTCATCGACTCCCGGCTGATACGCCTTATAAATGTCCAGAATGCAACTACAGCGTATCTAAGAGACACTTGCTGCACCAGCATCTGCGAGTACACGGAATCAAAAGAATTGAAACTGAGGCCGAATTAGAAGCGGCACCAAACAAACTAACTAAACTGGACTTCCACATTAATCTTGATGAAATACCATATGTCTGGGTTTCTGCCAAGAATGAGTTTCATAAAATGTACAAGTGTCGATATTGTTCATACGTTAATGCTGTAAAAAGCAAAATACCAAATCATGAAAAAATTCATTGCATCGTATTCGAAAACAATGATACAACTATCTACAAGTGTTTGGAATGTAAATTCACATGTGATAACGCCGGCAGGCTCGCCGAACATTCCAGAACTCACGGGGAAATATATGGTCGCATCTATTGTCCCGTTGAACATGATGTGCCAGATGATGAACAAATCACTAAATTGAGAAAGGTTATAGACATTGAAAAGTCAGCAAATCCAGAAAGTTTCTCTAGAGATGAAGGCACTAACGAATTAAGAGAAATAAAACTATTATATTTTTGTCAAAAGTGCCCAGCAAGATTTCTTGATGACGGTGAACTAGACGTTCATGAAAAATGTCATGATGTGACATTGCCCAATAAATGTAAAACTTGTGACTTTGCAGTCATCGAAGAAAATGAATTAGCGGCACATGACACCGTGCACACAGATGAATATCACACAAAAACGAAGATGCTTAAATTTGTTCACCACTCACATCCTTTGCACAAACAACCCGTGCTACAGTTTGTTCACTGTCCAAATACTTCAGAGATTACATGGCGAGCCACTGGGCCAAGTAAAGCTGAACATATCGAAAGTCATATGAAAAAAGAAACAAAACACGTGCCAAAACAATATTATTGCAAACAATGTCCAGCCAAGTTCTTCAAAAGTTCCGCGCTCACCTATCACATGGGGCTACATGGAGGTGAGGGCGAATATAAGTGCAAGAAGTGTAATTACGCCGTGAAGAACGTTGGAAATCTAGGCAAACATGAATTACTTCACGAAAATGAGAACAAGGCTACAACTTGCGACTATGAATCTGGAGAAGACATGGACTATAAAAATATTCCTTTGTCGGGCACAGATTTGTTCCAGAGAAAGACTGAGGCTCAGAAAAGAGTATTAACTGATAAAGATAAGTTAGTTAAGCCGAACGATCATTTTCCGCCTGTCCTACAAGCTGATCCCCAATTCGGTTATTTAATGCATGGTAATCCTGAATTTATATATCCCACGTACCTGAAAAATGGACGACAAAAAGAAAAGCGGTACAAATGCCACAAGTGCCCTTCAGCTTTTGAAAAAAGAGAACAATATAAAATTCATTTGTCATTGCACGGCTCCAAGCAAAGGTATAAATGTGAGTTATGTGACTATTCAGTAAAATATTACGCTAATTATGTTCAGCATATGCGAAAACATCAAATGAACGATGAAGCTCAAGCTGAAAGAAAGAAAGATAATAATGATTTTACAGAATCTGAACATCAAGAAGACGTTAAGCATGAAGACAGCAGTGATAACATCAAACTTGCAATAAAAACTATGCCAAAAGGAGCTGCTAAGAGCGACTTTCAACAATTCTCAATTAGCGACCAGCAAACGCTTAGACTGCTGCAGAGGAGACGGTCAATGAATAATTCTGGAAATGACCACAGCACTTCTGAAACTTCGCCGATCAAAGAGCGGAAAATGCACATGTGTCTGTTATGTCCCTACACTAACCAACGTCAAGATTCTTTAAGCAATCATTACAGAAGGCACGGTGACACCGATGTTCTGAACGGAGGCAGTCATAAATGCTCCCATTGCGACCTAGTGGTTGTTCAGTCACATTTCCTTCGGGAACACCTGAAGACACACTTCAACTACCACAAAACGCTTATTCCCGAATGTTTTGTGGCTAACGAAGCTGTTAGTTTTACCATAACCAAGTTGGATGAAGACAGTGAATCAGTTGATCTCAAATTAGACATGCAGAACAAGAGTTTTGCATGTAACGATGAAAAGATATTTGTAAAAATTAAAACTGGAGAGTTATTGGTGGAATAA
Protein Sequence
MLQQMSSPPSAQVGEVATIVRHLEGRVCGDVSSEASSDAAEDFELPQCKIRRNYNCTKCTFYTQNPRAYLVHTRDAHFVRLKIYDCPHCVYASRHHQKLIRHVKMVHGGSKPTSAASKADAELSPPSNDNMEPAERIEDMLEEVEDCEDMMMEVDDDSMDQPDDIDGDCDRSVDYASPSYRRAHLSKAKGKFFSCDKCNYVTHIRARFTKHVKYHSMPMIKCTMCDFRTPYKWNLDRHMKNHGGSGSFNCSMCNFTADIKQSLTVHEMNHHTPPAGQSLSSRRRNRVGASDTVIAEFDAASTLLPKEEEGSGDSRSSHSVSDMGLQYAERELVGCKSDSNDGTASDAITRKETSQDGYHQLSPTHSADEKQQKQSRKIPRPIPQLIPLNSSTPNQKQTCSGEPPQKKFKESLPIDIEDVSTENTLLPANPSIKETAGGRKKNESFFDKLKERLLTETGEEGSLICKICGFESKCLSEHSVHEKNCSPQTNRINANTSLKSLSSTRCQNCRHRCKSSADLYIHMQTCGKSEKIDDENNIKNENSSDEVIPIHEKETEPHPMENVVFVWNNINHDPNKFDIPLDININDDSTLPEIHRSFDAEIVDDNESMNLSPSQAIGRKVFKCPHCPFFSTTASRFHVHIVGHLNKKPFECSLCKYKSNWRWDITKHIKLKSARDPEHNEAKVLMTDETGRRNYSKYNKFLAMPVLNENGENEFHYLDPNTAVDSTMEMDESFNDMSDVMNVQFEMQPLNLQTQHSEDNYNYIDNRGLNDMKKPKKTLWKCKRCNYKDPSREALLEHVREHSRSDGIHDELNKPPIKKPENNTPDPADLAYRCGHCNQLSNWKHVIQRHCRLKHDGVIKVITTVKPKPDPPMNINEINIDTCNKCPYRTSDKKLLIAHLQQHQPSPNSIFKCYFCPFFVKDEPELIQHLLLHGITDPEDYIAKAMGTKSPGPEPQAPVTTTLNSTKRHKCIECPYETNSKSQFMYHEQFHRLPADTPYKCPECNYSVSKRHLLHQHLRVHGIKRIETEAELEAAPNKLTKLDFHINLDEIPYVWVSAKNEFHKMYKCRYCSYVNAVKSKIPNHEKIHCIVFENNDTTIYKCLECKFTCDNAGRLAEHSRTHGEIYGRIYCPVEHDVPDDEQITKLRKVIDIEKSANPESFSRDEGTNELREIKLLYFCQKCPARFLDDGELDVHEKCHDVTLPNKCKTCDFAVIEENELAAHDTVHTDEYHTKTKMLKFVHHSHPLHKQPVLQFVHCPNTSEITWRATGPSKAEHIESHMKKETKHVPKQYYCKQCPAKFFKSSALTYHMGLHGGEGEYKCKKCNYAVKNVGNLGKHELLHENENKATTCDYESGEDMDYKNIPLSGTDLFQRKTEAQKRVLTDKDKLVKPNDHFPPVLQADPQFGYLMHGNPEFIYPTYLKNGRQKEKRYKCHKCPSAFEKREQYKIHLSLHGSKQRYKCELCDYSVKYYANYVQHMRKHQMNDEAQAERKKDNNDFTESEHQEDVKHEDSSDNIKLAIKTMPKGAAKSDFQQFSISDQQTLRLLQRRRSMNNSGNDHSTSETSPIKERKMHMCLLCPYTNQRQDSLSNHYRRHGDTDVLNGGSHKCSHCDLVVVQSHFLREHLKTHFNYHKTLIPECFVANEAVSFTITKLDEDSESVDLKLDMQNKSFACNDEKIFVKIKTGELLVE