Basic Information

Gene Symbol
IKZF1
Assembly
GCA_949316375.1
Location
OX438691.1:9448991-9453432[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.17 15 7.0 3.4 2 22 182 202 181 202 0.95
2 16 0.069 6.3 8.2 2.6 1 23 298 320 298 320 0.95
3 16 0.48 43 5.6 0.3 2 23 458 479 457 479 0.96
4 16 0.00091 0.082 14.1 0.5 2 23 559 580 558 580 0.96
5 16 0.11 9.6 7.6 0.3 1 23 588 610 588 610 0.97
6 16 4 3.6e+02 2.7 2.6 1 23 646 668 646 668 0.93
7 16 0.00019 0.017 16.2 4.0 1 23 676 698 676 698 0.99
8 16 0.082 7.5 8.0 1.8 1 23 779 801 779 801 0.96
9 16 1.9 1.7e+02 3.7 2.2 1 20 857 876 857 879 0.91
10 16 0.66 60 5.1 0.1 2 23 886 907 886 907 0.93
11 16 0.03 2.7 9.4 2.5 1 23 974 996 974 996 0.95
12 16 0.0044 0.4 12.0 1.1 1 23 1002 1024 1002 1024 0.96
13 16 0.0054 0.49 11.7 2.6 1 23 1112 1134 1112 1134 0.97
14 16 0.00013 0.012 16.7 1.4 1 23 1140 1162 1140 1162 0.99
15 16 0.27 24 6.4 2.9 1 23 1252 1274 1252 1274 0.96
16 16 0.0079 0.71 11.2 5.6 1 23 1285 1307 1285 1307 0.98

Sequence Information

Coding Sequence
ATGGGTCTCCAATACGCAGAAAGGGAACTAGTCAGTTGCAAAAGTGATTCTAACGATGGTACAGCTTCTGACGCAATCACGAATCGAAAAGAGACTTCACAAGATGGATACAACCTCTCACCAACGCACAGCGCAGACGAGAAGCTACAGAAACAAAGCAGAAAGATTCCCAGGCCAATACCACAACTCATACCGTTAAATTCATCAACACCAAACCAAAAACAAACATGTTCTGGTGAACCACCACAAAAGAAGTTTAAAGAATCGTTACCCGTCGACAGCGATGATGTATCTGCTGAAAATACTCTCTTACCAGCAAACCCATTAATAAAAGAGACTGCAGGTCGAAAGAAGAATGAATCATTTTTCGACAGATTAAAAGAAAGACTGCTTACAGAAACAGGCGAAGAAGGTTCACTAATATGTAAGATCTGTGGATTTGAAAGTAAATGCCTATCAGAACATTCCGTACACGAGAAAAATTGTTCCCCACAAACGAATCGGATCAATGCAAACACGTCGCTTAAAAGTTTAAGTTCGACTCGATGCCAGAATTGCAGACACAGGTGTAAGTCTAGTGCAGACTTGTACATCCACATGCAAACTTGCGGAAAGAGCGAAATGGCCGACAATGAAAACATTAACATTGCAAATAGTAATGATGGAGTCATTCCCATCCATGAAACAGAGACTGAACCACATCCAATGGAAAACGTCGTTTTCGTTTGGAACAACATTAATCATGACCCTAACAAGTTTGATATACCTctagatataaatataaatgacgATTCCACTTTACCAGAAATGCATCGCAGTTTTGATGCCGAGATTGTCGATGAGAATGAAAGCATGAATCTGTCACCAAGTCAAGCTATTGGAAGGAAGGTATTTAAATGTCCACATTGTCCATTTTTCTCCACAACAGCATCCAGATTTCACGTTCATATCGTGGGTCACTTAAACAAGAAGCCATTTGAGTGTTCCCTCTGCAAATATAAGTCAAATTGGAGATGGGATATAACCAAACATATTAAGTTGAAATCCGCGAGGGATCCTGAGCATAATGAAGCAAAAGTACTTATGACTGATGAAACAGGAAGAAGAAACTATAGCAAATACAACAAATTCTTAGCAATGCCTGTTTTAAATGAACATGGTGAAAATGAGTTCCATTACCTGGATCCTAACACGGCAGTCGACAGCACAATGGAAATCGATGAATCATTTAATGATATATCAGACGTTATGAATGTACAATTTGAAATGCAACCGCTTAACTTACAGACCCAACACATTGAAGATAATTATAACAACTATATTGATAATAGAGGTCTCAACGATATGAAGAAGCCCAAGAAAACGTTATGGAAatgtaaaaaatgtaattacaaagaTCCCTCAAAAGAAGCTCTTTTAGAGCATGTTCGTGAACACTCCAGATCGGATGGCATCCATGATGAGCCACACAAGCCACCTATTAAGAAACCTGAAAACAATACTCCCGACCCAGCAGATCTAGCGTATCGTTGTGGGCATTGCAATCAACTGTCTAATTGGAAACATGTCATCCAGcGGCATTGCCGATTAAAACATGATGGAGTGATCAAAGTCATAACTACAGTTAAACCAAAACCTGACCCACCAATGAACATCAATGAAATCAACATTGATACCTGCAACAAATGTCCGTACAGAACGAGTGACAAAAAGCTGCTCATCGCTCACTTACAACAGCATCAGCCTTCGGCGGATTCTATTTTCAAATGCTACTTCTGTCCGTTCTTCGTAAAAGATGAGCCTGAATTAATTCAACATCTACTCCTACACGGTATCACTGACCCAGAAGATTACATCGCTAAAGCAATGGGAACTAAATCCCCAGGACCAGAACCGCAACCACCTGTTACTACATCATTAAACTCCACCAAGCGCCACAAATGCATAGAATGCCCATACGAAACCAACAGTAAGTCACAATTCATGTACCATGAACAATTTCATCGTCTTCCAGCCGATACACCTTATAAATGTCCAGAATGCAACTACAGCGTTTCTAAGAGACACCTGCTACACCAGCATCTGCGAGTCCACGGTATCGCAACCAAAAGAATTGAAACCGAAGCCGAATTAGAAGCATCAACCTCTACACAAAACAAATCAGACTTCCATAATAACCTTGATGAAATACAATTTGTCTGGGTTTCGGCTAAGAATGAGTTCCATAAAATGTACAAGTGCCGATACTGTTCATACGTTAAtgcaataaaatgtaaaataccaAATCATGAAAAAATTCATTGCATCGTATTCGAAAACAATGATACCACTGTTTACAAGTGTTTGGAATGCAAATTTACTTGTGATAATCCTAGCAGGCTCGCCGAGCATTCCAAAGGTCATGGGGAAATATATGGACGCATTTATTGTCCTGTTGAAGATGATGTACCCGATGAAGAACAGATCACAAAATTGAGAAGGGTTATGGAACTTGAAAAATCAGCAAATCCAGAAGGTTTCACAAGAGATGAAAGCTCTACGCATGAAAATAGagagattaaattattatatttttgtcaaaagtGTCCAGCAAGATTTTTTGATGAAACCGAACTTGACGTTCATGAAAAATGTCATGGTGTAACAATGCCAAACACTTGTAAAACTTGtgacttttcagtcactgaagaAGTTGACTTAGCGGCACATTTTGTTGTGCACACAGATGAATATCACACAAAAACGAAGATGCTTAAATTTATTCATAACTCACATCATTTACACCGGCAACCCGTGCTAGAACTTCTTCACTGTCCAAAGACTTCAGAGGTTAAGTGGATAGCCACTGGGCCAAGTAAAGCCGAACATATTGAAATccctgtaaaaaaaacaagtgataCAAAACACGTGCCAAAGCAATACTGTTGCAGACAATGTCCAGCGAAGTTTTTCAAAAGTTCCGCGCTTACCTATCACATGGGGCTGCATGGAGGAGAAGGCGAGCATAAGTGCAAAAAATGCAACTACGCCGTGAAGAACATTGGAAATCTGGCCAAACATGAACTACTTCACGAAAATGAGAACAAGGCTACAAATTGCGACTATGAATCCGGTGACGATatggattacaaaaatattccaTTGTCAGGCACAGATTTGTTCCAGAGGAAGACTGAGGCTCAAAAAAGAGTTTTAACCGATAAGTTAGTTAAGCCCAACGATCATTTTCCGCCGGTCCTACAAGCTGATCCCCAATTCGGTTATCTGATGCATGGGAATCCTGAATTTATATATCCGACGTATTTGAAAAATGGACgccaaaaagaaaaacgatACAAATGCCACAAGTGTCCTTCAGCGTTTGAGAAAAGAGAACAGTATAAGATTCATTTATCATTGCACGGCTctaaacaaagatataaatgtGAATTGTGTGATTATTCAGTGAAATATTACGCCAATTACGTTCAACACATGCGAAAACATCAAATGAACGATGAAGCTCAAGCTGAAAGGAAGAAGGGAAATGATTTTACAGAATCAGAACATCAAGAAAACGTGAAGCAAGAAGATAGCAGTGATAACATTAAACTTGCAATAAAAACGATGCCAAAAGGAGCTGCTAAGAGTGATTTTCAACAATTCTCAATTAGTGACCAACAAACACTCAGACTGCTGCAAAGAAGACGGTCAATGAATAATTCTGGAAACCTCAACTCTTCTGAAACTTCGCCGATGAAAGAGCGGAAAATGCACATGTGTCTATTATGTCCCTACACTAATCAACGTCAAGATTCTTTAACCAATCATTACAGGAGGCACGGTGACACCGATGTCCTGAACGGAGGTAGTCATAAATGTTCTCATTGCGACTTAGTGGTTGTTCAGTCGCATTTCCTTCGAGAACATCTCAAGACACACTTCAACTACCACAAAACTCTAATTCCCGAATGTTTTGTGGCCAACGAAGCTGTTAGTTTTACTATTACCAAGTTGGATGAAGATAGTGAACCAGTTGATCTCAAATTAGACATGCACAACAAGAGTTACGCATGTAATgacgaaaaaatatttgtgaaaattaAAACTGGAGAGCTATTGGTGGAATAA
Protein Sequence
MGLQYAERELVSCKSDSNDGTASDAITNRKETSQDGYNLSPTHSADEKLQKQSRKIPRPIPQLIPLNSSTPNQKQTCSGEPPQKKFKESLPVDSDDVSAENTLLPANPLIKETAGRKKNESFFDRLKERLLTETGEEGSLICKICGFESKCLSEHSVHEKNCSPQTNRINANTSLKSLSSTRCQNCRHRCKSSADLYIHMQTCGKSEMADNENINIANSNDGVIPIHETETEPHPMENVVFVWNNINHDPNKFDIPLDININDDSTLPEMHRSFDAEIVDENESMNLSPSQAIGRKVFKCPHCPFFSTTASRFHVHIVGHLNKKPFECSLCKYKSNWRWDITKHIKLKSARDPEHNEAKVLMTDETGRRNYSKYNKFLAMPVLNEHGENEFHYLDPNTAVDSTMEIDESFNDISDVMNVQFEMQPLNLQTQHIEDNYNNYIDNRGLNDMKKPKKTLWKCKKCNYKDPSKEALLEHVREHSRSDGIHDEPHKPPIKKPENNTPDPADLAYRCGHCNQLSNWKHVIQRHCRLKHDGVIKVITTVKPKPDPPMNINEINIDTCNKCPYRTSDKKLLIAHLQQHQPSADSIFKCYFCPFFVKDEPELIQHLLLHGITDPEDYIAKAMGTKSPGPEPQPPVTTSLNSTKRHKCIECPYETNSKSQFMYHEQFHRLPADTPYKCPECNYSVSKRHLLHQHLRVHGIATKRIETEAELEASTSTQNKSDFHNNLDEIQFVWVSAKNEFHKMYKCRYCSYVNAIKCKIPNHEKIHCIVFENNDTTVYKCLECKFTCDNPSRLAEHSKGHGEIYGRIYCPVEDDVPDEEQITKLRRVMELEKSANPEGFTRDESSTHENREIKLLYFCQKCPARFFDETELDVHEKCHGVTMPNTCKTCDFSVTEEVDLAAHFVVHTDEYHTKTKMLKFIHNSHHLHRQPVLELLHCPKTSEVKWIATGPSKAEHIEIPVKKTSDTKHVPKQYCCRQCPAKFFKSSALTYHMGLHGGEGEHKCKKCNYAVKNIGNLAKHELLHENENKATNCDYESGDDMDYKNIPLSGTDLFQRKTEAQKRVLTDKLVKPNDHFPPVLQADPQFGYLMHGNPEFIYPTYLKNGRQKEKRYKCHKCPSAFEKREQYKIHLSLHGSKQRYKCELCDYSVKYYANYVQHMRKHQMNDEAQAERKKGNDFTESEHQENVKQEDSSDNIKLAIKTMPKGAAKSDFQQFSISDQQTLRLLQRRRSMNNSGNLNSSETSPMKERKMHMCLLCPYTNQRQDSLTNHYRRHGDTDVLNGGSHKCSHCDLVVVQSHFLREHLKTHFNYHKTLIPECFVANEAVSFTITKLDEDSEPVDLKLDMHNKSYACNDEKIFVKIKTGELLVE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01231174;
90% Identity
iTF_00726922;
80% Identity
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