Dsec015082.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila seclusa
Gene Symbol
MBD2
Assembly
GCA_035043575.1
Location
JAWNMX010000859.1:6497709-6499496[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5e-22 2.6e-19 68.5 0.1 1 74 9 77 9 80 0.93
2 2 4.5e-05 0.078 12.6 0.1 27 76 191 249 173 250 0.89

Sequence Information

Coding Sequence
ATGCAAATGAATCCGAGTATTACCATCGAGAGAAAACGCGTTGATTGCAACGCATTACCAAAGGGCTGGCAGCGTGAGGAAGTACACAGAAAATCGAGCTGTAATTCGGGCGTTGATGTTTTCTACTACAGCCCGACAGGCAAAAGAATTGAAAGCAAACCGCAATTAGCACGCCAATTGAGCGCCGAGATGTTTGACATAAGCAACTTTGATTTTCAAACCGGCAAAATGCAGTTGCAACGGCAAATGCCCTCCCCATCGATATCGCTGTATCGCTGCAATGCAGCAGGCGCCATTATTAGCAATGCCAGCCTGGGTAGCAACGCCGCCAATGCACTCAAACGCAAATATAGTCGAGCTCAGGCTCAAGGCTCTAACAttaacatcagcaacatcagcagcaacaacaacaatcacagcaGCATCGGCATTGCAGCATCGTTAACAGGAACGGGAATAtcgacatcagcagcagcagcaaccacaacgacaacaactgcagcggcagctgctaatctgcgccagcaacaacaacagcagcagcagcaacaacaacaatttgaattcagCCGCGCTTTGCGCACAGATGTCTCACTGGTGCCGCCCATACGACAGACAGCCTCCATCTTCAAGCAGCCGGTGACTGTGGTGCGCAATCACGAGCCCAGCAAGGTGAAGCACGATGCGAAGCACGGTGGCCAGGAGAAGCCCAAGCAGCTGTTCTGGGAGAAGCGATTGGAACGCTTGCGTGCCTGCCATGACAACGGCGAGGAGCTGGACGAGATATCACTGCCAAAGACCATACGCACCGTCGGTCCCAATGTCAACGAACAGACGGTTCTACAATCTGTGGCCACGGCCCTCCATATGCTCAATGCCGGTGTGCACGGCCAGAGTTCGACCAAGGCTGAGCTCACAAAGAATGCGATGGCATTTATGAATCCCGAACAGCCGCTGATGCATGCGGTTATCATCTCAGAGGACGACATACGCAAGCAGGAGGATCGCGTAGGCGTGGCACGTCGAAAACTACAGGATGCGCTCAAGACATGA
Protein Sequence
MQMNPSITIERKRVDCNALPKGWQREEVHRKSSCNSGVDVFYYSPTGKRIESKPQLARQLSAEMFDISNFDFQTGKMQLQRQMPSPSISLYRCNAAGAIISNASLGSNAANALKRKYSRAQAQGSNINISNISSNNNNHSSIGIAASLTGTGISTSAAAATTTTTTAAAAANLRQQQQQQQQQQQQFEFSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPSKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDEISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00560262; iTF_00528039; iTF_00597352; iTF_00496590; iTF_00482224; iTF_00558653; iTF_00574040; iTF_00521344; iTF_00564642; iTF_00589539; iTF_00595238; iTF_00501796; iTF_00614180; iTF_00509092; iTF_00508325; iTF_00582950; iTF_00526567; iTF_00490771; iTF_00506101; iTF_00563168; iTF_00550887; iTF_00585191; iTF_00537505; iTF_00533795; iTF_00470864; iTF_00608436; iTF_00557909; iTF_00583675; iTF_00575577; iTF_00601786; iTF_00528798; iTF_00522952; iTF_00506859; iTF_00540360; iTF_00549544; iTF_00554377; iTF_00479476; iTF_00599578; iTF_00551579; iTF_00473055; iTF_00493641; iTF_00532362; iTF_01327883; iTF_01321185; iTF_00538221; iTF_00476616; iTF_00582248; iTF_00803592; iTF_00585961; iTF_00519915; iTF_00495854; iTF_00545230; iTF_00502516; iTF_00546646; iTF_00805176; iTF_00500301; iTF_00511268; iTF_00552296; iTF_00498865; iTF_00543735; iTF_00535303; iTF_01320461; iTF_00572590; iTF_00509807; iTF_00520623; iTF_00607057; iTF_00570386; iTF_00576338; iTF_00609875; iTF_00610643; iTF_00512712; iTF_00568971; iTF_01326387; iTF_01570227; iTF_00805962; iTF_00519156; iTF_00561029; iTF_00588837; iTF_01556116; iTF_00598144; iTF_00802836; iTF_00516981; iTF_00901493; iTF_00559479; iTF_00544483; iTF_00619831; iTF_01325655; iTF_00514169; iTF_01554691; iTF_00553029; iTF_01553223; iTF_00510536; iTF_01323369; iTF_01322638; iTF_01559026; iTF_01324887; iTF_00587391; iTF_01327161; iTF_00492954; iTF_00485851; iTF_00548795; iTF_00522163; iTF_00553723; iTF_00472355; iTF_01549563; iTF_00616188; iTF_00513450; iTF_00516253; iTF_00577053; iTF_00832157; iTF_00541758; iTF_00567529; iTF_00573310; iTF_00568242; iTF_00525119; iTF_00542431; iTF_00562463; iTF_00566783; iTF_00497377; iTF_00495104; iTF_00498144; iTF_00557203; iTF_00518432; iTF_00530944; iTF_00595936; iTF_00499577;
90% Identity
iTF_00597352;
80% Identity
-