Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 6e-20 1.9e-16 59.7 0.0 1 74 9 78 9 81 0.91

2 2 3.2e-05 0.1 12.5 0.0 27 76 179 237 166 238 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	6e-20	1.9e-16	59.7	0.0	1	74	9	78	9	81	0.91
2	2	3.2e-05	0.1	12.5	0.0	27	76	179	237	166	238	0.89

Coding Sequence: ATGCAAATGAATACGGGAAttacaattgaaagaaaacGCGTTGATTGCAGCGCATTACCAAAAGGCTGGCAACGCGACGAAGTACACAAAAAATCGGCATGCAATAACTTGGGCATTGATGTTTTCTACTACAGCCCCACAGGCAACAAAATTGAGAGCAAACAACAATTAGCACGTCAAATAAGTGGTGAGATGTTTGATAAAAGCAACTTTGATTTCCAAAGTGGAAAAatgcaactacaactacagcgCCAAATGCCTTCGCCATCCATATCCCTCTATCGATGCAATGCAGCTGGTACAATTATCAATAACACCGGTTCAGGTAGCAGCTCTGGCAATGCTCTCAAACGTAAATATAGCAGGGCTCAAATGCAAAGCtcttacaacaacaacaacaacaacaacaacagcagcgggaGTCTTCCGACTTCGTTAACAGCGTCAGCATTGGCATCATCGGGACCAATGACAACTGTAGCGGCGGCAGCTAATCtgcgccaacaacagcagcagcaacaatttgaaCTCAGTCGCGCTCTACGTACAGATGTTTCCCTGGTACCACCAATTCGACAGACTGCTTCCATATTCAAGCAGCCGGTTACAGTGGTACGCAACCACGAACCCAGCAAAGTCAAGCACGATGCCAAGCATGGTGGGcaggaaaaaccaaaacaactGTTCTGGGAAAAACGATTGGAACGTTTGCGTGCCTGCCATGACAATGGCGAGGAACTGGACGATATAACACTACCAAAAACCATCCGAACCGTAGGTCCCAATGTCAACGAACAAACGGTTTTGCAATCTGTAGCCACTGCGCTCCATATGCTTAATGCGGGGGTGCACGGACAAAGTTCCACAAAGGCAGACTTAAACAAGAACGCAATGGCTTTCATGAATCCAGAACAGCCGCTTATGCATGCAGTTATCATCTCAGAGGACGATATTCGCAAACAGGAAGATCGAGTAGGAATGGCACGAAGAAAATTACAAGATGCTCTTAAGATATGA
Protein Sequence: MQMNTGITIERKRVDCSALPKGWQRDEVHKKSACNNLGIDVFYYSPTGNKIESKQQLARQISGEMFDKSNFDFQSGKMQLQLQRQMPSPSISLYRCNAAGTIINNTGSGSSSGNALKRKYSRAQMQSSYNNNNNNNNSSGSLPTSLTASALASSGPMTTVAAAANLRQQQQQQQFELSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPSKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDDITLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLNKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGMARRKLQDALKI

Sequence clustering based on sequence similarity using MMseqs2