Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.4e-23 4.6e-20 71.2 0.0 1 74 7 75 7 78 0.94

2 2 2.6e-05 0.086 12.6 0.0 27 76 174 232 158 233 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.4e-23	4.6e-20	71.2	0.0	1	74	7	75	7	78	0.94
2	2	2.6e-05	0.086	12.6	0.0	27	76	174	232	158	233	0.89

Coding Sequence: ATGAATCCGAGTATTACTATTGAACGTAAACGCGTTGATTGCAACGCATTACCAAAAGGTTGGCAACGCGAGGAAGTGCACAGAAAATCGGGCTGCAACTCGGGCGTCGACGTTTTCTACTACAGCCCCACAGGTAAACGAATTGAAAGCAAACCACAATTAGCACGTCAATTGGGCGCCGAGATGTTTGACATAAGCAACTTTGATTTTCAAACCggcaaaatgcaattgcatCGACAAATGCCCTCGCCATCCATTTCACTATACCGATGCAATGCCGCTGGAGCAATTGTGAGCAATGCTGTCACTGGTGGAAATGTTGCAAATGCGCTTAAACGAAAATTTAGCAGAGCTCAATCCCAAAACGCGAACAATCTCGGCAGCAGGGGCGTTAGCATTGTGCCGTCGATATCATCCACAGCAGCGTCagtggtaacaacaacaacgacgactgCAGTGACGGCACCTAACgtgcggcagcagcaacaacatcaacaacaccaacaatttgaaatcagTCGCGCTCTGCGCACAGATGTCTCTTTGGTGCCACCGATTCGACAGACTGCCTCCATCTTCAAGCAACCGGTGACAGTGGTGCGCAACCATGAGCCCAACAAGGTCAAGCACGACGTTAAGCACGGTGGACAGGAAAAGCCAAAGCAGCTGTTCTGGGAGAAGCGCTTGGAGAGATTGCGCGCTTGCCACGACAACGGAGAGGAGCTCGATGATATATCACTGCCAAAGACCATAAGAACCGTAGGTCCCAATGTCAACGAACAGACTGTGCTCCAATCGGTGGCTACGGCTTTGCATATGCTAAATGCTGGGGTGCATGGACAGAGCTCCACGAAGGCTGAGCTATCGAAGAACGCTATGGCGTTCATGAATCCGGAACAGCCGCTCATGCATGCGGTTATAATCTCAGAGGACGACATACGAAAGCAGGAGGACCGTGTGGGTTTGGCCCGACGAAAGCTGCAGGATGCCCTCAAGGCTTGA
Protein Sequence: MNPSITIERKRVDCNALPKGWQREEVHRKSGCNSGVDVFYYSPTGKRIESKPQLARQLGAEMFDISNFDFQTGKMQLHRQMPSPSISLYRCNAAGAIVSNAVTGGNVANALKRKFSRAQSQNANNLGSRGVSIVPSISSTAASVVTTTTTTAVTAPNVRQQQQHQQHQQFEISRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPNKVKHDVKHGGQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELSKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGLARRKLQDALKA

Sequence clustering based on sequence similarity using MMseqs2