Basic Information

Gene Symbol
MBD2
Assembly
GCA_037044455.1
Location
JBAMBS010000177.1:88628-90227[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.5e-23 9.7e-20 70.3 0.0 1 74 9 78 9 81 0.95
2 2 3.7e-05 0.1 12.5 0.0 27 76 176 234 158 235 0.89

Sequence Information

Coding Sequence
ATGCAAATGAATCCGGGTATAACAATTGAACGAAAGCGCGTTGATTGCAGCGCATTACCAAAAGGCTGGCAACGCGAGGAAGTACACAGAAAATCTGCCTGCAATAACTCGGGCATTGACGTTTTCTACTACAGCCCCACAGGGAAACGAATTGAAAGCAAACCGCAATTAGTTCGTCTATTGAGTGCCGAGATGTTTGATATAAGCAACTTTGATTTCCAATCTGGAAAAATGCAACTACAACGACAAATGCCATCGCCATCTATATCCCTATATAGATGTAATGCAGCAGGTGCTATTATTAATAACAGTGGCGTAGGTGGTCATGCGGCTAATGCACTCAAACGAAAATATAGCCGTGGTCAAATTCATACCttttacaacaataacaacaatagcagctgTGGCGTTGCAACTTCAATAACGACAGCATCATCGGCATTAACATCATCAGGATCATTGACAACAACTGCAGCGACAGCAATTAATTTGCgtctacaacagcagcaacaatttgaaTTCAGTCGTGCTTTACGGACAGATGTCTCTCTTGTACCACCGATTCGACAGACTGCTTCCATATTTAAGCAACCGGTTACAGTGGTCCGCAATCATGAACATAGTAAAGTTAAGCACGATGCCAAGCATGGTGGCCaggaaaaaccaaaacaacttTTTTGGGAGAAACGCTTAGAGCGCCTACGGGCCTGCCATGACAATGGTGAGGAACTGGACGATATTACACTGCCAAAAACCATACGGACTGTAGGTCCTAATGTCAACGAACAGACTGTATTACAATCTGTAGCAACAGCACTTCATATGCTTAATGCTGGAGTACACGGACAAAGTTCCACAAAGGCTGAgctaaacaaaaatacaatggCATTCATGAATCCAGAACAACCGCTAATGCATGCAGTTATTATATCAGAAGAGGATATTCGGAAACAAGAAGATCGTGTTGGAGTGGCACGGAAAAAGTTACAAGACGctctaaaaatttaa
Protein Sequence
MQMNPGITIERKRVDCSALPKGWQREEVHRKSACNNSGIDVFYYSPTGKRIESKPQLVRLLSAEMFDISNFDFQSGKMQLQRQMPSPSISLYRCNAAGAIINNSGVGGHAANALKRKYSRGQIHTFYNNNNNSSCGVATSITTASSALTSSGSLTTTAATAINLRLQQQQQFEFSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEHSKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDDITLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELNKNTMAFMNPEQPLMHAVIISEEDIRKQEDRVGVARKKLQDALKI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00593092;
90% Identity
-
80% Identity
-