Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.2e-23 3.1e-20 71.1 0.0 1 74 7 75 7 78 0.94

2 2 1.8e-05 0.048 12.9 0.0 27 76 179 237 154 238 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.2e-23	3.1e-20	71.1	0.0	1	74	7	75	7	78	0.94
2	2	1.8e-05	0.048	12.9	0.0	27	76	179	237	154	238	0.88

Coding Sequence: ATGAATCCGAGTATTAGTATTGAACGTAAACGCGTTGACTGCAACGCACTACCTAAAGGTTGGCAACGCGAAGAAGTACACAGAAAATCGGGCTGCAATTCGGGCGTTGATGTTTTCTACTACAGCCCCACAGGCAAAAGAATTGAAAGTAAACCGCAATTAGCACGTCAATTGGGCGCCGAGATGTTTGACATTAGCAACTTTGATTTTCAAACCGGCAAAATGCAACTGCATCGACAAATGCCCTCGCCATCCATATCACTGTATCGATGCAATGCAGCGGGAACGATTATAAGCAACGCTGTCGCAGGTGgaaacagtgctgccaatgcCCTAAAACGTAAATTTAGCAGAGCCCAATCTCAAAGCtcaaacaataacagcaacagcggcagtgTGGGCATTGTGACGTcgatatcatcatcatcatcgccatCATCAGGCTCaccagtaacaacaacaactatggcAACATCTGCAATGACGGCAGCTAatcagcggcaacaacaacagcaacaacaatttgaattcAGCCGTGCTCTGCGCACAGATGTCTCCTTGGTGCCACCGATACGACAGACTGCCTCCATATTCAAGCAGCCGGTAACAGTAGTCCGAAATCACGAGCCCAACAAGGTGAAGCACGATGCCAAGCATGGGGGACAGGAGAAGCCCAAACAACTGTTCTGGGAGAAGCGATTGGAGCGTTTACGTGCCTGCCATGATAATGGTGAGGAACTGGACGAAATATCACTGCCAAAAACAATTCGAACTGTCGGTCCCAATGTTAACGAACAGACTGTACTGCAATCGGTAGCTACGGCACTGCATATGCTCAATGCTGGCGTGCACGGCCAAAGTTCCACAAAGGCTGAGCTAACGAAGAATGCAATGGCATTCATGAATCCCGAACAGCCGCTAATGCATGCGGTTATCATCTCAGAGGACGACATACGCAAGCAAGAGGATCGTGTGGGTTTGGCGCGACGAAAGCTACAGGATGCCCTCAAGACATGA
Protein Sequence: MNPSISIERKRVDCNALPKGWQREEVHRKSGCNSGVDVFYYSPTGKRIESKPQLARQLGAEMFDISNFDFQTGKMQLHRQMPSPSISLYRCNAAGTIISNAVAGGNSAANALKRKFSRAQSQSSNNNSNSGSVGIVTSISSSSSPSSGSPVTTTTMATSAMTAANQRQQQQQQQFEFSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPNKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDEISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGLARRKLQDALKT

Sequence clustering based on sequence similarity using MMseqs2