Basic Information

Gene Symbol
MBD2
Assembly
GCA_035045345.1
Location
JAWNPA010000020.1:29519510-29521065[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5.7e-23 1.3e-19 69.7 0.1 1 74 9 77 9 79 0.94
2 2 8.6e-06 0.019 14.7 0.1 27 76 172 230 153 231 0.88

Sequence Information

Coding Sequence
ATGCAAATGAATCCGAACATTACAATTGAAAGAAAACGCGTTGATTGCAACGCACTACCAAAGGGCTGGCAGCGTGAAGAAGTGCATAGGAAATCGGGTTGCAACTCGGGCGTTGATGTGTTCTACTACAGCCCGACCGGCAAACGAATTGAGAGTAAACCACAATTAGCACGCCAATTGAATACCGAAATGTTTGACATCagcaattttgattttcaaactggcaaaatgcaaatacaacgACAAATGCCCTCGCCATCCATATCGCTATACCGTTGCAATGCAGCGGGCGCCATCATCGGCAATGCTGGCCCTGGCGTTAACCCTGCTAATGCCTTAAAGCGTAAATACAGCCGTGCTCAAACGCAGGGCTCCGGGTCcaccaacaacatcaacagtgGGGGAATTGCAGCATCGATAACAGCAGTGCCATCGATAACCGCAACGACGGCAACTAATttgcgacagcagcagcagcagcagcaacaacagcaacaacaacttgaaaTCAGCCGCAATTTGCGTACAGATGTCTCCCTGGTGCCACCGATACGACAGACAGCTTCCATTTTCAAACAGCCCGTGACGGTTATCCGCAATCATGAACCGAGCAAAGTGAAGCACGACGTCAAACACGGCGGCCAGGAGAAGCCGAAACAGTTGTTTTGGGAGAAGCGCTTGGAGCGCTTGCGTGCCTGTCATGACAACGGTGAAGAACTCGACGATATATCACTGCCAAAAACCATACGCACCGTTGGCCCCAACGTCAACGAACAGACCGTATTGCAGTCGGTCGCCACCGCCTTGCATATGCTCAATGCCGGCGTACATGGCCAGAGCTCTACAAAGGCTGATTTAACGAAGAATGCCATGGCATTCATGAATCCCGAACAGCCGCTAATGCATGCGGTAATCATCTCCGAAGATGATATTCGCAAGCAGGAGGATCGCGTGGGAGTGGCACGAAAAAAACTGCAGGATGCGCTCAAGACATGA
Protein Sequence
MQMNPNITIERKRVDCNALPKGWQREEVHRKSGCNSGVDVFYYSPTGKRIESKPQLARQLNTEMFDISNFDFQTGKMQIQRQMPSPSISLYRCNAAGAIIGNAGPGVNPANALKRKYSRAQTQGSGSTNNINSGGIAASITAVPSITATTATNLRQQQQQQQQQQQQLEISRNLRTDVSLVPPIRQTASIFKQPVTVIRNHEPSKVKHDVKHGGQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARKKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00593092;
90% Identity
iTF_00532362;
80% Identity
-