Dleo013597.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila leonis
Gene Symbol
MBD2
Assembly
GCA_035045365.1
Location
JAWNPC010000715.1:111633-113176[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5.9e-21 1.4e-17 63.3 0.0 1 73 9 76 9 79 0.92
2 2 9.9e-06 0.023 14.5 0.1 27 76 176 234 157 235 0.89

Sequence Information

Coding Sequence
ATGCAAATGAATCCGAACATTACAATTGAAAGAAAACGCGTTGATTGCAACGCACTACCAAAGGGCTGGCAGCGGGAAGAAGTGAATAGGAAATCGGGTTGCAACACGGGCGTTGATGTGTTCTACTACAGCCCAACAGGCAAACGAATTGAAAGTGAACCACAATTAGCTCGTCAATTGAATACCGAAATGTTTGACATCAGCAATTTTGATATTCAAActggcaaaatgcaaatacaacgACAAATGCCTTCGCCATCCATATCGCTCTACCGCTGCAATGCAGCGGGCGCCATTATCAGCAATGCTGGCCCAGGTGGTAACGCTGCTAATGCTCTAAAGCGTAAATATAGCCGAGCTCAAGCGCTAAGCTGCGgatccaacaacaacatcaacagtgGGGGAATTCCAGCATCGATAACAGCAGTACCATcgataacaacagcaacaacggcaactaatttgcgccagcagcagcagcagcaacaacaacaacaacagcaacaacaacaatttgaattcaGCCGTAATTTGCGCACAGATGTCTCCCTGGTGCCACCGATACGACAGACAGCTTCCATTTTCAAGCAGCCGGTGACGGTTATCCGCAATCATGAGCCGAGCAAGGTGAAGCATGATGTCAAACACGGCGGCCAGGAGAAGCCGAAACAGTTGTTCTGGGAGAAGCGCTTGGAGCGCTTGCGTGCCTGTCATGACAATGGTGAAGAACTCGATGATATATCACTGCCAAAAACCATACGCACCGTTGGCCCCAATGTCAACGAACAGACCGTATTGCAATCGGTGGCCACCGCCTTGCATATGCTCAATGCCGGCGTACATGGCCAGAGCTCTACGAAGGCTGATCTAACGAAGAATGCTATGGCATTCATGAATCCCGAACAGCCGCTAATGCACGCGGTTATCATCTCCGAGGATGATATTCGCAAGCAAGAGGATCGCGTGGGAGTGGCACGGAAAAAACTCCAAGATGCGCTCAAGACATGA
Protein Sequence
MQMNPNITIERKRVDCNALPKGWQREEVNRKSGCNTGVDVFYYSPTGKRIESEPQLARQLNTEMFDISNFDIQTGKMQIQRQMPSPSISLYRCNAAGAIISNAGPGGNAANALKRKYSRAQALSCGSNNNINSGGIPASITAVPSITTATTATNLRQQQQQQQQQQQQQQQFEFSRNLRTDVSLVPPIRQTASIFKQPVTVIRNHEPSKVKHDVKHGGQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARKKLQDALKT