Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 9.2e-22 1.8e-18 65.9 0.0 1 74 9 77 9 80 0.93

2 2 4e-05 0.079 12.6 0.1 27 76 191 249 173 250 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	9.2e-22	1.8e-18	65.9	0.0	1	74	9	77	9	80	0.93
2	2	4e-05	0.079	12.6	0.1	27	76	191	249	173	250	0.89

Coding Sequence: ATGCAAATGAATCCGAGTATTACAATCGAGAGAAAACGCGTTGATTGCAACGCATTACCAAAGGGCTGGCAACGTGAGGAAGTACACAGAAAATCGAGCTGTAATTCGGGCGTTGATGTTTTCTACTACAGCCCGGCAGGCAAAAGAATTGAAAGCAAACCGCAATTAGCACGTCAATTGAGCGCCGAGATGTTTGACATAAGCAACTTTGATTTTCAAACCGGCAAAATGCAGTTGCAACGGCAAATGCCCTCCCCATCGATATCGCTATATCGCTGCAATGCAGCAGGCGCCATTATTAGCAATGCCAACCTGGGTAGCAACGCCGCCAATGCACTCAAACGTAAATATAGTCGAGCTCAGGCTCAAGGCTCTAACATtagcatcagcaacatcagcagcaacaacaacaatcacagcaGCATCGGCATTGCAGCATCGTTAACAGGAACGGGAATAtcgccatcagcagcagcagcaaccacaacgacaacaactgcagcggcagctgctaatctgcgccagcaacaacagcaacagcagcagcaacaacaacaatttgaattcagCCGCGCTTTGCGCACAGATGTTTCACTGGTGCCGCCCATACGACAGACAGCCTCCATCTTCAAGCAGCCGGTGACTGTGGTGCGCAATCACGAGCCCAGCAAGGTGAAGCACGATGCCAAGCACGGTGGCCAGGAGAAGCCCAAGCAGCTGTTCTGGGAGAAGCGATTGGAACGCTTGCGTGCCTGCCATGACAACGGCGAGGAGCTGGACGAGATATCACTGCCAAAGACCATACGCACCGTCGGTCCCAATGTCAACGAACAGACGGTTCTACAATCTGTGGCCACGGCCCTCCATATGCTCAATGCCGGTGTGCACGGCCAGAGTTCGACCAAGGCTGAGCTCACAAAGAATGCGATGGCATTTATGAATCCCGAACAGCCGCTGATGCATGCGGTTATCATCTCAGAGGACGACATACGCAAGCAGGAGGATCGCGTAGGCGTGGCACGGCGAAAACTACAGGATGCGCTCAAGACATGA
Protein Sequence: MQMNPSITIERKRVDCNALPKGWQREEVHRKSSCNSGVDVFYYSPAGKRIESKPQLARQLSAEMFDISNFDFQTGKMQLQRQMPSPSISLYRCNAAGAIISNANLGSNAANALKRKYSRAQAQGSNISISNISSNNNNHSSIGIAASLTGTGISPSAAAATTTTTTAAAAANLRQQQQQQQQQQQQFEFSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPSKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDEISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Sequence clustering based on sequence similarity using MMseqs2