MBD
- Domain
- MBD domain
- Group
- Unclassified Structure
- PFAM
- PF01429
- Desciption
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Rederence
-
- A mammalian protein with specific demethylase activity for mCpG DNA. Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M. Nature 397, 579-83, (1999).
- Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. Nan X, Meehan RR, Bird A. Nucleic Acids Res. 21, 4886-92, (1993).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000356 | Abrostola tripartita | Atri009291.1 | Mbd3 |
| iTF_00000357 | Abrostola tripartita | Atri020617.1 | MBD-R2 |
| iTF_00000358 | Abrostola tripartita | Atri010809.1 | - |
| iTF_00000359 | Abrostola tripartita | Atri007127.1 | egg |
| iTF_00000360 | Abrostola tripartita | Atri000934.1 | baz-2 |