Basic Information

Gene Symbol
MBD2
Assembly
GCA_004143805.1
Location
SCDV01000618.1:20187-21864[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.2e-22 5.4e-19 68.2 0.1 1 74 9 77 9 80 0.94
2 2 2.5e-05 0.12 12.6 0.1 27 76 178 236 162 237 0.89

Sequence Information

Coding Sequence
ATGCAAATGAATCCGAGCATCACAATCGAGAGGAAACGCGTTGATTGCAACGCACTACCAAAGGGTTGGCAGCGCGAGGAAGTGCACAGGAAATCCAGCTGCAGCACGGGCGTTGACGTTTTCTACTACAGTCCCACAGGCAAACGCATTGAAAGCAAACCGCAATTAGCACGCCAATTAAGCGCCGAGATGTTTGACATCAGCAACTTCGACTTTCAAAccggcaaaatgcaaatgcaacggCAAATGCCATCGCCATCCATATCCCTATATCGTTGCAATGCAGCGGGCGCCATTATCGGGAATGCGGGCCTAGGTGGCAATGCTGCCAATGCACTTAAACGTAAATATAGCCGAGTTCAGGCCCAAagctccaacaacaacaacagcagcatcagtgGTGGTATTGCAGCGtcgataacagcagcagcagcatcgatgacagcagcggcggcaacaacaactgcgggGGCTGCAGTAAATctgcgccagcaacaacaacaacagcagcagcaacaatttgaattcagCCGTGCTCTGCGCACAGATGTCTCCCTGGTGCCGCCCATACGACAGACCGCCTCCATATTCAAGCAACCGGTGACAGTGGTGCGCAACCATGAGCCCAGCAAGGTGAAGCACGATGCCAAACACGGTGGCCAGGAGAAGCCCAAGCAGCTGTTCTGGGAGAAGCGGCTGGAGCGTTTGCGTGCCTGTCATGACAACGGCGAAGAACTGGACGATATTTCACTGCCAAAAACCATACGCACCGTTGGACCCAATGTCAACGAACAGACGGTTTTGCAATCGGTGGCCACGGCGCTGCATATGCTCAATGCCGGCGTCCATGGCCAGAGCTCGACGAAAGCTGAGCTGACCAAGAATGCGATGGCATTCATGAATCCTGAACAGCCGTTAATGCATGCAGTTATTATATCGGAAGATGATATACGCAAGCAGGAAGatcgtgtgggcgtggcacgacGAAAACTACAAGATGCGCTCAAGATATGA
Protein Sequence
MQMNPSITIERKRVDCNALPKGWQREEVHRKSSCSTGVDVFYYSPTGKRIESKPQLARQLSAEMFDISNFDFQTGKMQMQRQMPSPSISLYRCNAAGAIIGNAGLGGNAANALKRKYSRVQAQSSNNNNSSISGGIAASITAAAASMTAAAATTTAGAAVNLRQQQQQQQQQQFEFSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPSKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00593092;
90% Identity
iTF_00598144;
80% Identity
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