Dmel000752.2
Basic Information
- Insect
- Drosophila melanocephala
- Gene Symbol
- MBD2
- Assembly
- GCA_037043625.1
- Location
- JBAMBD010000012.1:819530-821332[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 6.7e-21 1.3e-17 63.1 0.1 1 74 9 78 9 81 0.92 2 2 4.2e-05 0.079 12.5 0.1 27 76 195 253 178 254 0.89
Sequence Information
- Coding Sequence
- ATGCAAATGAATCCGAGTATTACAATCGAGAGAAAACGCGTTGATTGCAACGTATTACCCAAAGGCTGGCAGCGTGAGGAAGTACATAGAAAATCGAGCTGCAATTCGGGCGTTGATGTTTTCTACTACAGCAGCCCGACAGGCAAAAGAATTGAAAGCAAACCGCAATTAGCACGCCAATTGACTGCCGAGATGTTTGACATAAGCAACTTTGATTTTCAAACCGGCAAAATGCAGTTGCAACGGCAAATGCCTTCCCCATCAATATCGCTGTATCGCTGCAATGCAGCAGGCGCCATTATTAGCAATGCCAGCCTGGGTGGCAACGCAGCCAATGCACTCAAACGCAAATATAGTCGAGCTCAGACTCAAGGCTctaacatcaacatcagcaacatcagcagcaacaacaacaatcacagcagcagcaacatcggCATTGCAGCatcaataacagcaacaggaatatcgccatcatcagcagcagcaacgacaacgacaacaactgcagcggcagcagctaatctgcgccagcaacaacaacaacagcaacagcagcaacaacaacaatttgaattcagCCGCGCTCTGCGCACAGATGTCTCGCTGGTGCCGCCCATACGACAGACAGCCTCCATCTTCAAGCAGCCGGTGACTGTGGTGCGCAATCACGAGCCCAGCAAGGTGAAGCACGATGCCAAGCACGGCGGCCAGGAGAAGCCCAAGCAGCTATTCTGGGAGAAGCGATTGGAGCGCTTGCGTGCCTGCCATGACAACGGCGAGGAGCTGGACGAGATATCACTGCCAAAGACCATACGCACCGTCGGTCCCAATGTCAACGAACAGACTGTTCTACAATCTGTGGCCACGGCCCTCCATATGCTCAATGCCGGTGTGCACGGCCAGAGTTCGACCAAGGCTGAGCTCACAAAGAATGCGATGGCATTTATGAATCCCGAACAGCCGCTGATGCATGCGGTTATCATCTCAGAGGACGACATACGCAAGCAGGAGGAtcgcgtgggcgtggcacgcCGAAAACTACAGGATGCGCTCAAGACATGA
- Protein Sequence
- MQMNPSITIERKRVDCNVLPKGWQREEVHRKSSCNSGVDVFYYSSPTGKRIESKPQLARQLTAEMFDISNFDFQTGKMQLQRQMPSPSISLYRCNAAGAIISNASLGGNAANALKRKYSRAQTQGSNINISNISSNNNNHSSSNIGIAASITATGISPSSAAATTTTTTAAAAANLRQQQQQQQQQQQQQFEFSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPSKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDEISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00593092;
- 90% Identity
- iTF_00597352;
- 80% Identity
- -