Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 8e-24 1.7e-20 72.3 0.0 1 74 7 75 7 78 0.94

2 2 3.2e-05 0.068 12.7 0.0 27 76 171 229 154 230 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	8e-24	1.7e-20	72.3	0.0	1	74	7	75	7	78	0.94
2	2	3.2e-05	0.068	12.7	0.0	27	76	171	229	154	230	0.89

Coding Sequence: ATGAATCCAAGTATTACTATTGAACGTAAACGCGTTGATTGCAACGTACTACCAAAAGGTTGGCAACGCGAAGAAGTACACAGAAAATCGGGCTGCAACTCGGGTGTTGATGTTTTTTACTACAGCCCAACAGGCAAAAGAATTGAAAGCAAACCGCAATTAGCACGTCAATTGGGCGCCGAGATGTTTGACATAAGTAACTTTGATTTTCAAACCGGCAAAATGCAACTGCATCGACAAATGCCCTCGCCATCCATATCGCTGTATAGATGCAATGCAGCGGGAGCCATTATCAGCAACGCTGTGGCAGGTGGGAATTCTGCCAATGCTCTCAAGCGTAAATTTAGCAGAGTTCAATCTCTaaacacaaacaataacagcaacagcagcgtagGCATTGTGACGTCGATATCATCAGCAGCTTCAGCagtaacaacgacaacaactacagtgtCGGCAGCTAAtctgcggcaacaacaacaacaacagcaacaacaatttgaattcagTCGCGCTTTGCGCACAGATGTTTCCTTGGTCCCGCCGATACGACAGACTGCCTCTATATTCAAACAGCCTGTGACAGTAGTGCGTAATCATGAACCTAACAAGGTTAAGCACGACGCCAAGCATGGTGGCCAGGAGAAACCTAAACAATTATTCTGGGAGAAACGTTTGGAGCGTTTGCGCGCCTGCCACGACAACGGCGAGGAACTGGACGATATATCACTGCCAAAAACCATTAGAACTGTCGGTCCCAATGTTAACGAACAGACTGTATTGCAATCGGTAGCTACGGCACTGCATATGCTAAATGCCGGCGTGCACGGCCAGAGTTCCACAAAGGCAGAGCTAACTAAGAATGCAATGGCATTCATGAATCCAGAACAGCCGCTAATGCATGCTGTTATAATCTCAGAGGACGATATACGCAAACAAGAAGACCGTGTGGGCTTGGCGCGACGAAAGCTACAGGATGCTCTCAAAATATGA
Protein Sequence: MNPSITIERKRVDCNVLPKGWQREEVHRKSGCNSGVDVFYYSPTGKRIESKPQLARQLGAEMFDISNFDFQTGKMQLHRQMPSPSISLYRCNAAGAIISNAVAGGNSANALKRKFSRVQSLNTNNNSNSSVGIVTSISSAASAVTTTTTTVSAANLRQQQQQQQQQFEFSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPNKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGLARRKLQDALKI

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00593092;
90% Identity: iTF_00533795; iTF_00522952; iTF_00585961; iTF_00585191; iTF_00506859; iTF_00568971; iTF_00470864; iTF_00519156; iTF_00575577; iTF_00601786; iTF_00528798;
80% Identity: -