Basic Information

Gene Symbol
topi
Assembly
GCA_963978555.1
Location
OZ021704.1:44728432-44731372[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.0021 0.33 12.7 2.1 2 21 103 122 102 123 0.94
2 14 5.7e-06 0.00089 20.7 1.2 1 23 148 170 148 170 0.98
3 14 0.021 3.3 9.5 2.0 2 23 177 198 177 198 0.95
4 14 0.21 33 6.4 0.2 2 19 217 234 216 237 0.82
5 14 0.0028 0.42 12.3 0.8 2 23 288 309 287 309 0.97
6 14 2 3.1e+02 3.3 0.1 1 20 315 334 315 336 0.84
7 14 0.0023 0.35 12.5 3.4 2 22 352 372 351 375 0.88
8 14 0.00067 0.1 14.2 0.1 1 23 480 503 480 503 0.96
9 14 0.0073 1.1 11.0 0.2 1 23 507 529 507 529 0.97
10 14 6.8e-07 0.00011 23.6 2.4 1 23 535 557 535 557 0.98
11 14 0.019 3 9.6 0.1 1 23 563 588 563 588 0.96
12 14 0.067 10 7.9 2.9 1 23 594 616 594 616 0.86
13 14 4.2e-06 0.00065 21.2 0.3 1 23 622 644 622 644 0.98
14 14 2.8e-06 0.00043 21.7 2.2 1 23 650 673 650 673 0.98

Sequence Information

Coding Sequence
ATGAACACCCTTGATAATAACACAATTATAAACGTATataaaatagaagaaaatggaATTGCGACTTCAGGAATGTGGTATGAAATGAATTCAAACACCAAAGATCCTATATCTACAAATAACTTTTGTCCAGTAAACGTAAGCTTTGATCCCAATACATTATTATCTAACGAAAATCGATTTACATTGAATTTACGCCAATTCGAGAACAATGAAGATTTTGTTAAGTGTATTAAGTTTGAAGATACATATGACTCGCCATCGATAAACGTGGGTAAGGCCATTTTGAATATTCCAACTATGATAAGATGCCAAAATTGTGAGACTAATTTTCCCACTAAATATCAATATCAAAGGCATCAGTGTGAATTTAATGCCGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAATGAAGTAGATACTGGTATTCCCGTTAAATATATTTGCGAATTTTGCAATAAACAGTTTGTTAATAGAAATAACTTAGCTCGTCACCAGTCTAGCCACGAGAATACTCAAGAAAATGTGTGCGAACATTGCAGCAAACAATTTATTAGTGAAAATCGTTTGAGAATACACAAAGAAAACCATTGTAAAAAAGCTGGAGACATTTCTAAATTCTACCGAAGCGATGTGGCTGTCTGGAAATGTAAAAAGTGCTATGAAGTGTTTTCTTCGCCATTAACAGCAAACTATCACGTGACATCTTGTGTAGAAACCATAGAAATCGAAGACGAAGCAGAAAAATCCACACAATCATCGGACGAAGACAAAATTGACTTGACTTATgaacaaatttacaaaaaagaaGCAATTGACGAGAAAAACATAGAAAAAGTATTAACCGAGCTCCTACTACAATGTGAATTCTGCAACAGAACGTACGCTGAGAAAAATGTGCTGCTTCTGCACCAAAGGAAACACACCACAGCCAGAAATTACGAATGTGTCAATTGCTTCCAAGTTTTCGATTCTTATCCAACAGCTGCCCAACATTGGATGAAAAAATGCTCAGAATACGTTAGTCTGTTTTACTTACCAAAATTAACCTACTGTGAATACTGCGACCGAACATTCAAATCTCACGAACTGCTCTACACgcacaaaattaaaaaaaagcacTACACTTCCAAGCTCCATCTACATCCGACAGAAGAAACCAACAAAGATGTCGGTGTTGCAGTTCccgaaaaaagtgtcgataacAAAGAAATTCTCAACAAATTAATCGAGGACGTTTTAAAAACTCTAGATGTCCCTGTTAACAAAATCAACTGTCAAGGAATGGATTCAAATAAAGAGAATAACGGCGAACAAATGAAAAATTGCGTTGATACTACGGAAAAGAAAAAGAGAGGAAGAAAACGTAAATGGCCTAAAAATCAATGCGCGAGAACGAAAAAACTTAGCCTGGAAGTCGACGATGGTTATAAATACCAATGCGAAAGGTGCAATGAAACTTTTATAAACGTCGAAGATCTCGAGGGACATCGGGAAAAGGAGCATGCTTCGAATTTCACTTGTGATGAATGTGGACAgattttgCATAGCGCCAAAGCTTTGATGATACACAGCCGTGCTCATAAAATGTTGAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTATTCCCAAACTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGAATAAAGCCTTTTGCGTGCCCACACGAGGGCTGTGAAGCGAGATACACGATACGGCCGGATTTGAAGGATCATATAAGAAAAGCCCACACTAGAGAGCGACCATTCAAATGCAACGTGTGCGATAAATGTTTTTTAACAGGTTCTGTCTATTACCAGCATCGTTTGATACATACCAATGACAGAAGATATGCATGTGATCTCTGTCCAAAACGGTTTTTTAGAGCCGATGCTCTTAATAATCACCGAAGGATCCATACCGACGAACGTCCTTATCCTTGTCATGTATGCGGAAGGGAATTTAGACAGAAAGGAGATCGTAATAAACATCTTAGGACTCAGCACCCGGATAcggttttagtttaa
Protein Sequence
MNTLDNNTIINVYKIEENGIATSGMWYEMNSNTKDPISTNNFCPVNVSFDPNTLLSNENRFTLNLRQFENNEDFVKCIKFEDTYDSPSINVGKAILNIPTMIRCQNCETNFPTKYQYQRHQCEFNAEKVVLKSDVDSNEVDTGIPVKYICEFCNKQFVNRNNLARHQSSHENTQENVCEHCSKQFISENRLRIHKENHCKKAGDISKFYRSDVAVWKCKKCYEVFSSPLTANYHVTSCVETIEIEDEAEKSTQSSDEDKIDLTYEQIYKKEAIDEKNIEKVLTELLLQCEFCNRTYAEKNVLLLHQRKHTTARNYECVNCFQVFDSYPTAAQHWMKKCSEYVSLFYLPKLTYCEYCDRTFKSHELLYTHKIKKKHYTSKLHLHPTEETNKDVGVAVPEKSVDNKEILNKLIEDVLKTLDVPVNKINCQGMDSNKENNGEQMKNCVDTTEKKKRGRKRKWPKNQCARTKKLSLEVDDGYKYQCERCNETFINVEDLEGHREKEHASNFTCDECGQILHSAKALMIHSRAHKMLKPYVCETCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRYACDLCPKRFFRADALNNHRRIHTDERPYPCHVCGREFRQKGDRNKHLRTQHPDTVLV