Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387422.1:129208113-129210503[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.00097 0.23 13.5 2.8 2 21 97 116 96 117 0.94

2 14 3.5e-06 0.00083 21.2 1.8 1 23 142 164 142 164 0.98

3 14 0.029 6.8 8.9 0.6 2 23 171 192 171 192 0.96

4 14 0.035 8.2 8.6 0.2 2 21 211 230 210 231 0.91

5 14 0.00061 0.14 14.2 1.5 2 23 283 304 282 304 0.97

6 14 2.4 5.7e+02 2.8 0.9 1 12 310 321 310 323 0.89

7 14 0.002 0.46 12.6 3.4 2 22 347 367 346 370 0.88

8 14 0.016 3.7 9.7 0.1 1 23 469 492 469 492 0.97

9 14 0.0015 0.36 12.9 0.0 1 23 496 518 496 518 0.97

10 14 5.8e-07 0.00014 23.7 2.4 1 23 524 546 524 546 0.98

11 14 0.017 3.9 9.7 0.1 1 23 552 577 552 577 0.96

12 14 0.14 34 6.7 1.2 1 23 583 605 583 605 0.84

13 14 3.1e-06 0.00071 21.4 0.2 1 23 611 633 611 633 0.98

14 14 0.0026 0.62 12.2 3.7 1 23 639 662 639 662 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.00097	0.23	13.5	2.8	2	21	97	116	96	117	0.94
2	14	3.5e-06	0.00083	21.2	1.8	1	23	142	164	142	164	0.98
3	14	0.029	6.8	8.9	0.6	2	23	171	192	171	192	0.96
4	14	0.035	8.2	8.6	0.2	2	21	211	230	210	231	0.91
5	14	0.00061	0.14	14.2	1.5	2	23	283	304	282	304	0.97
6	14	2.4	5.7e+02	2.8	0.9	1	12	310	321	310	323	0.89
7	14	0.002	0.46	12.6	3.4	2	22	347	367	346	370	0.88
8	14	0.016	3.7	9.7	0.1	1	23	469	492	469	492	0.97
9	14	0.0015	0.36	12.9	0.0	1	23	496	518	496	518	0.97
10	14	5.8e-07	0.00014	23.7	2.4	1	23	524	546	524	546	0.98
11	14	0.017	3.9	9.7	0.1	1	23	552	577	552	577	0.96
12	14	0.14	34	6.7	1.2	1	23	583	605	583	605	0.84
13	14	3.1e-06	0.00071	21.4	0.2	1	23	611	633	611	633	0.98
14	14	0.0026	0.62	12.2	3.7	1	23	639	662	639	662	0.98

Sequence Information

Coding Sequence: ATGAATACCCTTGATAATAACATAATTGTAAACGTATATAAAATAGAAAAAAATGGGACGGCGTCTTCAGGAATGTGGTATGGAAAGAATTCAAGCAAAAATAACATTTATCCAGTAAACGTAAGCTTTGATCCTGATATATTATTATCTAATGAAAAGCGATTAACATTGAATTTAAGCCAATTCAAGAACAATGAATATTTTGTTAAGTGTAATAAGTTTGAAGATAAAGATGACTCACCATCGATATATGTCGGTAAGACCGTTTTGAATATTCCTACTATGGTAAGATGCCAAAATTGTGAGACTAATTTTTCCACTAAATATCAATATCAAAGGCATCAGTGTGAATTTAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGATGGCGGTATTCCCGTTAAATACATTTGCGAATTTTGCAATAAACAGTTTGTTAATAAAAAGAATTTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAACAATTTATTGGTGAAAATCGTTTGAGGATACACAAAGAAAAACATTGTAAAAAAGATGGAGACATTTCTAAATTTTACAGAAGCGATGTGGCTGTTTGGAAATGCAAAAAGTGTTATGAAGTATTTTCTTCACCTTTATCAGCAAATTATCACATGACATCTTGTGTAGAAATCGTAGAAATCGAAGACGATGAAGCAGAAAAAACAACACAATTATCGGACGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAGAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTACACCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAATTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGGAAAAGTGTTCGGAATACGTAAATCTGTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATTCAAATCTCACGAACTACTCTACACGCACAAAATAAAAAAGAAGCACTATACTTACAAGCTCCAAACTGAAGAAACCAACAAAGTTGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACGAATCGAGGACGTTTTAGAAACTTTAGACGTCCCAGTTAACAAAATCCACTATCAAGGAACAGACGCAAATAAAGAGAATACCGGCGAACAACTTGAAAATTCTGTTGATACAACGGAAAAGAAGAAGAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGCGAGAACGAAAAAACCGAGTCTTCAAGTCGACGACGGTTATAAATATCAATGCGAAAGGTGCATCGAAACTTTTATAAATGTTGACGATCTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGACAGGTTTTGCAAAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTATTCCCAAACTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCCCTCACGAAGGCTGTGAAGCGAGATACACGATACGTCCGGatttgaaggatcatataagaaaagcccacactagagagagaccattcaaatgcaacgtttgcgataaaTATTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGATATGCATGTGATCTCTGTCCTAAGCGGTTTTTTAGAGCCTCTGCTCTCAATATTCACCGAAGGATCCATACCGACGAACGCCCTTACCCTTGCCATGTATGCCGAAGGCAGTTTAGACAGAAAGGAGTTCGTAACAAACATCTTAAGACTCAGCATCCTGTTTCAGTTTAA
Protein Sequence: MNTLDNNIIVNVYKIEKNGTASSGMWYGKNSSKNNIYPVNVSFDPDILLSNEKRLTLNLSQFKNNEYFVKCNKFEDKDDSPSIYVGKTVLNIPTMVRCQNCETNFSTKYQYQRHQCEFNAEKVVLKSDVDSSETDGGIPVKYICEFCNKQFVNKKNLVRHQSSHENTQENVCENCNKQFIGENRLRIHKEKHCKKDGDISKFYRSDVAVWKCKKCYEVFSSPLSANYHMTSCVEIVEIEDDEAEKTTQLSDEDKVVLTNENIHTKEAIDKKNIEKISTELLLQCEFCNRTYTEKKVLLIHQRKHTTARNYECVNCFKVFDSYPIAAQHWMEKCSEYVNLFYLPKLTYCEYCDRTFKSHELLYTHKIKKKHYTYKLQTEETNKVVDVTVPEDNKNILNKRIEDVLETLDVPVNKIHYQGTDANKENTGEQLENSVDTTEKKKRGRKRKWPTNLSARTKKPSLQVDDGYKYQCERCIETFINVDDLEEHREKVHASNFTCDECGQVLQNAKALIVHSRAHKMLKPYVCETCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKAHTRERPFKCNVCDKYFLTGSVYYQHRLIHTNDRRYACDLCPKRFFRASALNIHRRIHTDERPYPCHVCRRQFRQKGVRNKHLKTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: iTF_00912468;