Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387434.1:10562284-10564607[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0024 0.57 12.3 2.6 2 21 98 117 97 118 0.94

2 14 2.1e-06 0.00049 21.9 2.2 1 23 142 164 142 164 0.98

3 14 0.005 1.2 11.3 1.0 2 23 171 192 171 192 0.95

4 14 0.027 6.3 9.0 0.4 2 19 211 228 210 231 0.84

5 14 0.0011 0.26 13.3 0.8 2 23 283 304 282 304 0.97

6 14 0.33 78 5.6 0.1 1 20 310 329 310 331 0.84

7 14 0.002 0.46 12.6 3.4 2 22 347 367 346 370 0.88

8 14 0.043 10 8.3 0.1 1 23 473 496 473 496 0.97

9 14 0.0025 0.57 12.3 0.1 1 23 500 522 500 522 0.97

10 14 5.9e-07 0.00014 23.7 2.4 1 23 528 550 528 550 0.98

11 14 0.017 3.9 9.6 0.1 1 23 556 581 556 581 0.96

12 14 0.024 5.7 9.1 2.7 1 23 587 609 587 609 0.86

13 14 3.6e-06 0.00085 21.2 0.3 1 23 615 637 615 637 0.98

14 14 9.1e-05 0.021 16.8 3.9 1 23 643 666 643 666 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0024	0.57	12.3	2.6	2	21	98	117	97	118	0.94
2	14	2.1e-06	0.00049	21.9	2.2	1	23	142	164	142	164	0.98
3	14	0.005	1.2	11.3	1.0	2	23	171	192	171	192	0.95
4	14	0.027	6.3	9.0	0.4	2	19	211	228	210	231	0.84
5	14	0.0011	0.26	13.3	0.8	2	23	283	304	282	304	0.97
6	14	0.33	78	5.6	0.1	1	20	310	329	310	331	0.84
7	14	0.002	0.46	12.6	3.4	2	22	347	367	346	370	0.88
8	14	0.043	10	8.3	0.1	1	23	473	496	473	496	0.97
9	14	0.0025	0.57	12.3	0.1	1	23	500	522	500	522	0.97
10	14	5.9e-07	0.00014	23.7	2.4	1	23	528	550	528	550	0.98
11	14	0.017	3.9	9.6	0.1	1	23	556	581	556	581	0.96
12	14	0.024	5.7	9.1	2.7	1	23	587	609	587	609	0.86
13	14	3.6e-06	0.00085	21.2	0.3	1	23	615	637	615	637	0.98
14	14	9.1e-05	0.021	16.8	3.9	1	23	643	666	643	666	0.98

Sequence Information

Coding Sequence: ATGGACACCTTTGATAATGACATAATTGTAAACGTATATAAAATAGAAGAAAATGGGACAGTGTCTTCAGGAATGCGGTATGGAGAGAATTCAAGCACCGAAGATAACTTTTGTCCAGAAAACGTAAGCCTTGATCCTGCTATATTATTATCTAATGAAAACCGATTAACATTGAATTTAAGCCAATTCAAAAACAATGAATATTCTGTTAAGTGTACGAAGCTTGAAGATAGATATGACTCACCATCGATATGTGTCGGTAAGACCTTTTTGAATATTCCTACTATGATAAGATGCCAAAATTGTGAGACTAATTTTCCCACTAAATATCAATATCAAAGGCATCAGTGTCAATATAATGCAGAAAAAGTTGTCTTAAAATCGGATGCTGATTCTAGTGAAGCTGGCGGTATTCCCGTTAAATACATATGCGAATTTTGCAATAAAAAGTTTGTTAATAAAAAAAATTTGGTTCGTCACCAATCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAAAAATTTATTAGTGAAAATCGTTTGAGGATACACAAAGAAAACCATTGTAAAAAATCTAGAGAAATTTCTAAATTTTACAGAAGCGATGTGGCTGTCTGGAAATGCAAAAAGTGTCATGAAGTATTTTCTTCACCTTTATCAGCAAATTATCACGTGACATCTTGCGTAGAAATCGTAGAAATCGAAGACGATGAAGCAGAAAAAACAACACAATTATCGGAGGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATCGACGAGAAAAACATAGAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTACGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAATTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAACAGCCGCCCAACATTGGATGAAAAAGTGTTCCGAATACGTAAATCTGTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATTCAAATCTCACGAACTACTCTACACGCACAAAATAAAAAAGAAGCACTATACTTACAAGCTCCATTTACGACAAACTGAAGAAACCATCAACAAAGATGTCGATGTTGCAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGAGGACGTTTTCAAAACTTTAGACGTCCCAGTTAACAAAATCAACTATCAAGGAACAGACGCAAATAAAGAGAATACCGGCGAACAACTTGAAAATTCTGTCGATACTACGGAAAAGAAGAAAAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGTGAACACGAAAAAACCGAGTCTGCAAGTCGACGACGGTTATAGATATCAATGCGAAAGGTGCATCGAAACTTTTATGAATGTTGACGATCTTGAGGAACATCGAGAGAAGGTACATGCTTCGAATTTCACTTGCGAAGAATGTGGACAGGTTTTGCATAACGCCAAAGCTTTGGTAGTACACAGTCGTGCTCATAAGATGTTGAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTACTCCCAAACTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCCCTCACGAAGGCTGTGAAGCGAGATACACGATACGTCCGGATTTGAAGGATCATATAAGAAAGGCCCACACTAGAGAGAGGCCATTCAAATGCAACGTGTGCGGTAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGATATGCATGTGATCTCTGTCCCAAACGGTTTTTTAGAGCCGATGCTCTCAATAATCACCGAAGGATCCATACCGACGAACGCCCTTACCCTTGTCATGTTTGCCGAAGGCAGTTTAGACAGAAAGGAGATCGTAACAAACATCTTAGGACTCAGCATCCGGTTTCAGTTTAA
Protein Sequence: MDTFDNDIIVNVYKIEENGTVSSGMRYGENSSTEDNFCPENVSLDPAILLSNENRLTLNLSQFKNNEYSVKCTKLEDRYDSPSICVGKTFLNIPTMIRCQNCETNFPTKYQYQRHQCQYNAEKVVLKSDADSSEAGGIPVKYICEFCNKKFVNKKNLVRHQSSHENTQENVCENCNKKFISENRLRIHKENHCKKSREISKFYRSDVAVWKCKKCHEVFSSPLSANYHVTSCVEIVEIEDDEAEKTTQLSEEDKVVLTNENIHTKEAIDEKNIEKISTELLLQCEFCNRTYAEKKVLLIHQRKHTTARNYECVNCFKVFDSYPTAAQHWMKKCSEYVNLFYLPKLTYCEYCDRTFKSHELLYTHKIKKKHYTYKLHLRQTEETINKDVDVAVPEDNKNILNKLIEDVFKTLDVPVNKINYQGTDANKENTGEQLENSVDTTEKKKRGRKRKWPTNLSVNTKKPSLQVDDGYRYQCERCIETFMNVDDLEEHREKVHASNFTCEECGQVLHNAKALVVHSRAHKMLKPYVCETCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKAHTRERPFKCNVCGKCFLTGSVYYQHRLIHTNDRRYACDLCPKRFFRADALNNHRRIHTDERPYPCHVCRRQFRQKGDRNKHLRTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: -