Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387426.1:47937095-47939385[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.0013 0.3 13.2 1.5 2 21 97 116 96 117 0.94

2 13 4e-06 0.00093 21.1 1.5 1 23 142 164 142 164 0.98

3 13 0.031 7.3 8.8 0.2 2 20 171 189 171 191 0.92

4 13 0.13 32 6.8 0.2 2 19 211 228 210 231 0.84

5 13 0.00025 0.059 15.4 1.0 2 23 284 305 283 305 0.97

6 13 2.3 5.4e+02 2.9 0.9 1 12 311 322 311 324 0.89

7 13 0.00098 0.23 13.5 3.8 2 22 348 368 347 371 0.89

8 13 0.098 23 7.2 0.3 4 23 466 485 466 485 0.95

9 13 1.2e-07 2.8e-05 25.8 2.3 1 23 491 513 491 513 0.98

10 13 0.015 3.6 9.8 0.1 1 23 519 544 519 544 0.96

11 13 0.054 13 8.0 2.9 1 23 550 572 550 572 0.86

12 13 1.6e-05 0.0037 19.1 1.1 1 23 578 600 578 600 0.96

13 13 0.012 2.8 10.1 6.0 1 23 606 629 606 629 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.0013	0.3	13.2	1.5	2	21	97	116	96	117	0.94
2	13	4e-06	0.00093	21.1	1.5	1	23	142	164	142	164	0.98
3	13	0.031	7.3	8.8	0.2	2	20	171	189	171	191	0.92
4	13	0.13	32	6.8	0.2	2	19	211	228	210	231	0.84
5	13	0.00025	0.059	15.4	1.0	2	23	284	305	283	305	0.97
6	13	2.3	5.4e+02	2.9	0.9	1	12	311	322	311	324	0.89
7	13	0.00098	0.23	13.5	3.8	2	22	348	368	347	371	0.89
8	13	0.098	23	7.2	0.3	4	23	466	485	466	485	0.95
9	13	1.2e-07	2.8e-05	25.8	2.3	1	23	491	513	491	513	0.98
10	13	0.015	3.6	9.8	0.1	1	23	519	544	519	544	0.96
11	13	0.054	13	8.0	2.9	1	23	550	572	550	572	0.86
12	13	1.6e-05	0.0037	19.1	1.1	1	23	578	600	578	600	0.96
13	13	0.012	2.8	10.1	6.0	1	23	606	629	606	629	0.98

Sequence Information

Coding Sequence: ATGAACACCCTTAATAATAACACAATTGTAAAGGTATATAAAATAGAAGAAAATGGGACGGCGTCTTCAGGAATGTGGTATGGAAAGAATTCAAGCACAAATAACTTTTGTCCAGTAAACGTAAGCTTTGATCCTGATATATTATTATCTAATGAAAACCGATTAACATTGAATTTAAGCCAATTCAAGAACAATGAATATTTTGTTAAGTGTACTAAGTTTGAAGATAGATATGACTCACCATCGATATATGTCGGTAAGACCGTTTTGAATATTCCTACTATGATAAGATGCCAAAATTGTGAGACTATTTTTCCCACTAAATATCAATATCAAAGGCATCAGTGTGAATATAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGATGGCGGTATTCTCGTTAAATACATTTGCGAATTTTGCAATAAACAGTTTGTTAATAAAAATAATCTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAACAATTTATTAGTGAAAATCGTTTGAGGATACACAAAGAAAACAATTGTAAAAAAGCTGGAGACATTTCTAAATTTTACAGAAGCGATGTGGCTGTTTGGAAATGCAAAAAGTGTTATGAAGTATTTTCTTCACCTTTATCAGCAAATTATCACGTGACATCTTGTGTAGAAATCGTAGAAATCGAAGACGATGAAGCAGAAAAAACAATAACACAATTATCGGACGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAGAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTTCGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAACTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTTTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATTCAAATCTCACGAACAACTCTACACGCACAAAATAAAAAAGAAGCACTATACTTACAAGCTGCATCTACGACAAACTGAAGAAACCAACAAAGATGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGAGGACGTTTTAGAAACTTTAGACGTCCCAGTTAACAAAATCCACTATCAAGGAACAGACGCAAATAAAGAGAATACCGGCGAACAGCTTGAAAATTCTGTTGATACCACGGAAAAGAAGAAGAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGCGACAACGAAAAAACCGAGTCTTCATGAATGTGGAAAGGTTTTGCATAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAATCGTATGTTTGTGAAACTTGCGGCCGAAGCTATTCCCAATCTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCCCTCACGAAGGCTGTGAAGCGAGATACACGATACGTCCGGATTTGAAGGATCATATAAGAAGAGCCCACACTAGAGAGAGACCATTCAAATGCAACGTTTGCGATAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGACATGCATGTGATCTCTGTCCTAGACGGTTTTTTAGAGCCGATGATCTCAATAATCACCGAAGGATCCATACCGGCGAACGCCCTTACTCTTGCCATGTATGCCGAAGGCAGTTTAGACAGAAACGAGTTCGTAACAAACATCTTAAGACTCAGCATCCTGTTTCAGTTTAA
Protein Sequence: MNTLNNNTIVKVYKIEENGTASSGMWYGKNSSTNNFCPVNVSFDPDILLSNENRLTLNLSQFKNNEYFVKCTKFEDRYDSPSIYVGKTVLNIPTMIRCQNCETIFPTKYQYQRHQCEYNAEKVVLKSDVDSSETDGGILVKYICEFCNKQFVNKNNLVRHQSSHENTQENVCENCNKQFISENRLRIHKENNCKKAGDISKFYRSDVAVWKCKKCYEVFSSPLSANYHVTSCVEIVEIEDDEAEKTITQLSDEDKVVLTNENIHTKEAIDKKNIEKISTELLLQCEFCNRTFAEKKVLLIHQRKHTTARNYECVNCFKVFDSYPIAAQHWMKKCSEYVNLFYLPKLTYCEYCDRTFKSHEQLYTHKIKKKHYTYKLHLRQTEETNKDVDVTVPEDNKNILNKLIEDVLETLDVPVNKIHYQGTDANKENTGEQLENSVDTTEKKKRGRKRKWPTNLSATTKKPSLHECGKVLHNAKALIVHSRAHKMLKSYVCETCGRSYSQSSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRRAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRHACDLCPRRFFRADDLNNHRRIHTGERPYSCHVCRRQFRQKRVRNKHLKTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: -