Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387426.1:47836062-47838447[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0014 0.32 13.1 1.5 2 21 103 122 102 123 0.94

2 14 4.3e-06 0.001 20.9 1.5 1 23 148 170 148 170 0.98

3 14 0.034 7.9 8.7 0.2 2 20 177 195 177 197 0.92

4 14 0.22 51 6.1 0.1 2 19 217 234 216 237 0.84

5 14 0.0011 0.26 13.3 0.8 2 23 290 311 289 311 0.97

6 14 2.5 5.8e+02 2.8 0.9 1 12 317 328 317 330 0.89

7 14 0.0011 0.25 13.4 3.8 2 22 354 374 353 377 0.89

8 14 0.016 3.7 9.7 0.1 1 23 479 502 479 502 0.97

9 14 0.00028 0.065 15.2 0.2 1 23 506 528 506 528 0.97

10 14 1.3e-07 3e-05 25.7 2.3 1 23 534 556 534 556 0.98

11 14 0.0096 2.3 10.4 0.2 1 23 562 587 562 587 0.96

12 14 0.058 14 7.9 2.9 1 23 593 615 593 615 0.86

13 14 1.1e-05 0.0027 19.6 0.9 1 23 621 643 621 643 0.96

14 14 0.032 7.5 8.8 4.3 1 23 649 672 649 672 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0014	0.32	13.1	1.5	2	21	103	122	102	123	0.94
2	14	4.3e-06	0.001	20.9	1.5	1	23	148	170	148	170	0.98
3	14	0.034	7.9	8.7	0.2	2	20	177	195	177	197	0.92
4	14	0.22	51	6.1	0.1	2	19	217	234	216	237	0.84
5	14	0.0011	0.26	13.3	0.8	2	23	290	311	289	311	0.97
6	14	2.5	5.8e+02	2.8	0.9	1	12	317	328	317	330	0.89
7	14	0.0011	0.25	13.4	3.8	2	22	354	374	353	377	0.89
8	14	0.016	3.7	9.7	0.1	1	23	479	502	479	502	0.97
9	14	0.00028	0.065	15.2	0.2	1	23	506	528	506	528	0.97
10	14	1.3e-07	3e-05	25.7	2.3	1	23	534	556	534	556	0.98
11	14	0.0096	2.3	10.4	0.2	1	23	562	587	562	587	0.96
12	14	0.058	14	7.9	2.9	1	23	593	615	593	615	0.86
13	14	1.1e-05	0.0027	19.6	0.9	1	23	621	643	621	643	0.96
14	14	0.032	7.5	8.8	4.3	1	23	649	672	649	672	0.98

Sequence Information

Coding Sequence: ATGAACACCCTTAATAATAACACAATTGTAAAGGTATATAAAGTAGAAGAAAATGGGACGGCGTCTTCAGGAATGTGGTATGGAAAGAATTCAAGCACCGAAGATCCTATATCTACAAATAACTTTTGTCCAGTAAACGTAAGCTTTGATCCTGATATATTATTATCTAATGAAAACCGATTAACATTGAATTTAAGCCAATTCAAGAACAATGAATATTTTGTTAAGTGTATTAAGTTTGAAGATAGATATGACTCACCATCGATATATGTCGGTAAGACCGTTTTGAATATTCCTACTATGATAAGATGCCAAAATTGTGAGACTATTTTTCCCACTAAATATCAATATCAAAGGCATCAGTGTGAATATAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGATGGCGGTATTCCCGTTAAATACATTTGCGAATTTTGCAATAAACAGTTTGTTAATAAAAATAATTTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAACAATTCATTAGTGAAAATCGTTTGAGGATACACAAAGAAAACAATTGTAAAAAAGCTGGAGACATTTATAAATTTTACAGAAGCGATGTGGCTGTTTGGAAATGCGAAAAGTGTTATGAAGTATTTTCTTCACCTTTATCAGCAAATTATCACGTGACATCTTGTGTAGAAATCGTAGAAATCGAAGACGATGAAGCAGAAAAAACAATAACACAATTATCGGACGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAGAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTACGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAATTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTGTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATTCAAATCTCACGAACAACTCTACACGCACAAAATAAAAAAGAAGCACTATACTTACAAGCTGCATCTACGACAAACTGAAGAAACCAAGAAAGATGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGACGACGTTTTAGAAACTTTAGACGTCCCAGTTAACAAAATCCACTATCAAGGAACAGACGCAAATAAAGAGAATACCGGCGAACAACTTGAAAATTCTGTTGATACAACGGAAAAGAAGAAGAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGCGAGAACGAAAAAACCGAGTCTTCAAGTCGACGACGGTTATAAATATCAATGCGAAAGGTGCATCGAAACTTTTATAAATGTTGACGATCTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGAAAGGTTTTGCATAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAACCGTATGTTTGTGAAACTTGCGGCAGAAGCTATTCCCAATCTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCCCTCACGAAGGCTGTGAAGCGAGATATACGTTACGTCCGGATTTGAAGGATCATATAAGAAAAGCCCACACTAGAGAGAGACCATTCAAATGCAACGTTTGCGATAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGACATGCATGTGATCTCTGTCCTAAACGGTTTTTTAGAGCCGATGCTCTCAATAATCACCGAAGGATCCATACCGACGAACGACCTTACCCTTGCCATGTATGCCGAAGGCAGTTTAGAGAGAAACGAGTTCGTAACAAACATCTTAAGACTCAGCATCCTGTTTCAGTTTAA
Protein Sequence: MNTLNNNTIVKVYKVEENGTASSGMWYGKNSSTEDPISTNNFCPVNVSFDPDILLSNENRLTLNLSQFKNNEYFVKCIKFEDRYDSPSIYVGKTVLNIPTMIRCQNCETIFPTKYQYQRHQCEYNAEKVVLKSDVDSSETDGGIPVKYICEFCNKQFVNKNNLVRHQSSHENTQENVCENCNKQFISENRLRIHKENNCKKAGDIYKFYRSDVAVWKCEKCYEVFSSPLSANYHVTSCVEIVEIEDDEAEKTITQLSDEDKVVLTNENIHTKEAIDKKNIEKISTELLLQCEFCNRTYAEKKVLLIHQRKHTTARNYECVNCFKVFDSYPIAAQHWMKKCSEYVNLFYLPKLTYCEYCDRTFKSHEQLYTHKIKKKHYTYKLHLRQTEETKKDVDVTVPEDNKNILNKLIDDVLETLDVPVNKIHYQGTDANKENTGEQLENSVDTTEKKKRGRKRKWPTNLSARTKKPSLQVDDGYKYQCERCIETFINVDDLEEHREKVHASNFTCDECGKVLHNAKALIVHSRAHKMLKPYVCETCGRSYSQSSHLWQHMRFHQGIKPFACPHEGCEARYTLRPDLKDHIRKAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRHACDLCPKRFFRADALNNHRRIHTDERPYPCHVCRRQFREKRVRNKHLKTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: -