Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387422.1:28053273-28055410[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0015 0.36 12.9 2.1 2 21 15 34 14 35 0.94

2 14 1.2e-06 0.00027 22.7 0.8 1 23 60 82 60 82 0.98

3 14 0.027 6.2 9.0 0.3 2 20 89 107 89 109 0.92

4 14 0.047 11 8.2 0.2 2 20 129 147 128 149 0.89

5 14 0.00095 0.22 13.6 0.8 2 23 198 219 197 219 0.97

6 14 2.1 4.9e+02 3.0 0.9 1 12 225 236 225 238 0.89

7 14 0.0018 0.42 12.7 3.3 2 22 262 282 261 285 0.88

8 14 0.021 5 9.3 0.1 1 23 387 410 387 410 0.97

9 14 0.00062 0.14 14.1 0.0 1 23 414 436 414 436 0.97

10 14 2.7e-06 0.00064 21.6 2.0 2 23 443 464 443 464 0.96

11 14 0.0091 2.1 10.5 0.7 1 23 470 495 470 495 0.96

12 14 0.049 11 8.2 2.9 1 23 501 523 501 523 0.86

13 14 8.7e-06 0.002 20.0 0.7 1 23 529 551 529 551 0.98

14 14 4.8e-05 0.011 17.6 3.7 1 23 557 580 557 580 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0015	0.36	12.9	2.1	2	21	15	34	14	35	0.94
2	14	1.2e-06	0.00027	22.7	0.8	1	23	60	82	60	82	0.98
3	14	0.027	6.2	9.0	0.3	2	20	89	107	89	109	0.92
4	14	0.047	11	8.2	0.2	2	20	129	147	128	149	0.89
5	14	0.00095	0.22	13.6	0.8	2	23	198	219	197	219	0.97
6	14	2.1	4.9e+02	3.0	0.9	1	12	225	236	225	238	0.89
7	14	0.0018	0.42	12.7	3.3	2	22	262	282	261	285	0.88
8	14	0.021	5	9.3	0.1	1	23	387	410	387	410	0.97
9	14	0.00062	0.14	14.1	0.0	1	23	414	436	414	436	0.97
10	14	2.7e-06	0.00064	21.6	2.0	2	23	443	464	443	464	0.96
11	14	0.0091	2.1	10.5	0.7	1	23	470	495	470	495	0.96
12	14	0.049	11	8.2	2.9	1	23	501	523	501	523	0.86
13	14	8.7e-06	0.002	20.0	0.7	1	23	529	551	529	551	0.98
14	14	4.8e-05	0.011	17.6	3.7	1	23	557	580	557	580	0.98

Sequence Information

Coding Sequence: ATGTATGTCGGTAAGACCGTTTTGAATATTCCTACTATGATAAGATGCCAAAATTGTGAGACTAATTTTCCCACTAAATATCAATATCAAAGGCATCAGTGTGAATTTAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGATGGCGGTATTCCCGTTAAATACATTTGCGAAGTTTGCAATAAACAGTTTGTTAATAAAAATAATTTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAACAATTTATTAGTGAAAATCGTTTGAAGATACACAAAGAAAACTATTGTAAAAAAGCTGGAGACATTTCTAAATTTTACAGAAGCGATGTGGCTGTTTGGAAATGCAAAAAGTGTTATGAAGTATTTTCTTCACCTTTATTAGCAAATTATCACATGACATCTTGTGTAGAAATCGAAGACGATGAAGCAGAAAAAACAACACAATTATCGGACGAGGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAGAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTACGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAATTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTGTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATTCAAATCTCACGAACTACTCTACTCGCACAAAATAAAAAAGAAGCACTATACTTACAAGCTCCATCTACGACAAACTGAAGAAACCAACAAAGATGTCGTTGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGATGACGTTTTAGAAACTTTAGACGTCCCAGTTAACAAAATCCGCTATCAAGGAACAGACGCAAATAAAGAGAATGCCGGCGAACAACTTGAAAATTCTGTTGATACAACGGAAAAGAAGAAGAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGCGAGAACGAAAAAACCGAGTCTTCAAGTCGACGACGGTTGTAAATATCAATGCGAAAGGTGCATCGAAACTTTTATAAATGTTGAAGATCTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGACAGGTTTTGGATAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAACCGAATGTTTGTGAAACTTGTGGCCGAAGCTATTCCCAAACTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCCCTCACGAAGGCTGTGAAGCGAGATACACGATACGTCCGCATTTGAAGGATCATATAAGAAAAGCCCACACTAGAGAGAGACCATTCAAATGCAACGTTTGCGATAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGATATGCATGTGATCTCTGTCCTAAACGGTTTTTTAAAGCCTATGATCTCAATAATCACCGAAGGATCCATACCGACGAACGCCCTTACCCTTGCCATGTATGCCAAAGGCAGTTTACACGGAAAGCAGATCGTAACAAACATCTTAAGACTCAGCATCCTGTTTCAGTTTAA
Protein Sequence: MYVGKTVLNIPTMIRCQNCETNFPTKYQYQRHQCEFNAEKVVLKSDVDSSETDGGIPVKYICEVCNKQFVNKNNLVRHQSSHENTQENVCENCNKQFISENRLKIHKENYCKKAGDISKFYRSDVAVWKCKKCYEVFSSPLLANYHMTSCVEIEDDEAEKTTQLSDEDKVVLTNENIHTKEAIDKKNIEKISTELLLQCEFCNRTYAEKKVLLIHQRKHTTARNYECVNCFKVFDSYPIAAQHWMKKCSEYVNLFYLPKLTYCEYCDRTFKSHELLYSHKIKKKHYTYKLHLRQTEETNKDVVVTVPEDNKNILNKLIDDVLETLDVPVNKIRYQGTDANKENAGEQLENSVDTTEKKKRGRKRKWPTNLSARTKKPSLQVDDGCKYQCERCIETFINVEDLEEHREKVHASNFTCDECGQVLDNAKALIVHSRAHKMLKPNVCETCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPHLKDHIRKAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRYACDLCPKRFFKAYDLNNHRRIHTDERPYPCHVCQRQFTRKADRNKHLKTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: -