Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387422.1:117824292-117826666[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.024 5.6 9.1 3.6 2 21 103 122 102 123 0.94

2 14 1.4e-06 0.00033 22.5 0.8 1 23 147 169 147 169 0.98

3 14 0.034 7.9 8.7 0.2 2 20 176 194 176 196 0.92

4 14 0.33 77 5.6 0.2 2 19 216 233 215 236 0.79

5 14 0.0011 0.26 13.3 0.8 2 23 288 309 287 309 0.97

6 14 0.94 2.2e+02 4.1 0.9 1 12 315 326 315 328 0.89

7 14 0.0011 0.25 13.4 1.9 2 20 352 370 351 375 0.90

8 14 0.016 3.7 9.7 0.1 1 23 478 501 478 501 0.97

9 14 0.0015 0.34 13.0 0.1 1 23 505 527 505 527 0.97

10 14 3.2e-06 0.00074 21.4 0.9 1 23 533 555 533 555 0.98

11 14 0.0046 1.1 11.4 0.5 1 23 561 586 561 586 0.95

12 14 0.058 14 7.9 2.9 1 23 592 614 592 614 0.86

13 14 1e-05 0.0024 19.7 0.7 1 23 620 642 620 642 0.98

14 14 3.3e-06 0.00078 21.3 3.3 1 23 648 671 648 671 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.024	5.6	9.1	3.6	2	21	103	122	102	123	0.94
2	14	1.4e-06	0.00033	22.5	0.8	1	23	147	169	147	169	0.98
3	14	0.034	7.9	8.7	0.2	2	20	176	194	176	196	0.92
4	14	0.33	77	5.6	0.2	2	19	216	233	215	236	0.79
5	14	0.0011	0.26	13.3	0.8	2	23	288	309	287	309	0.97
6	14	0.94	2.2e+02	4.1	0.9	1	12	315	326	315	328	0.89
7	14	0.0011	0.25	13.4	1.9	2	20	352	370	351	375	0.90
8	14	0.016	3.7	9.7	0.1	1	23	478	501	478	501	0.97
9	14	0.0015	0.34	13.0	0.1	1	23	505	527	505	527	0.97
10	14	3.2e-06	0.00074	21.4	0.9	1	23	533	555	533	555	0.98
11	14	0.0046	1.1	11.4	0.5	1	23	561	586	561	586	0.95
12	14	0.058	14	7.9	2.9	1	23	592	614	592	614	0.86
13	14	1e-05	0.0024	19.7	0.7	1	23	620	642	620	642	0.98
14	14	3.3e-06	0.00078	21.3	3.3	1	23	648	671	648	671	0.98

Sequence Information

Coding Sequence: ATGAACACCCTTGATAATAACGCAATTGTAAAAGTATATAAAATCGAAAAAAATGGGACGGCGTCTTCAGGAATGTGGTATGGAAAGAATTCAAGCACCGAAGATCCTATATCTACAAATAACTTTTGCCCAGTAAACGTAAGCTTTGATCCTGATATATTATTATCTAATGAAAACCGATTAACATTGAATTTAAGCCAATTCAAGAACGATGAATATTTTGTTAAGTGTATTAAATTAGAAGATAGATATGACTCACCATCGATATATGTCGGTAAGACCGTTTTGAATCTTCCTACTATGATAAGATGCCAAAATTGTGAGACTATTTTTCCCACTAAATGTCAATATCAAAGGCATCAGTGTGAATTTAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGGCGATATTCCCGTTAAATACATTTGCGAAGTTTGCAATAAACAGTTTGTTAATAAAAATAATTTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAACAATTTATTAGTGAAAATCGTTTAAGGATACACAAAGAAAACTATTGTAAAAAAGCTGGACACATTTCTAAATTTTACAGAAGCGATGTGGATGTTTGGAAATGCAAAAAGTGTTATGAAGTATTTTCTTCACTTTTATCAGCAAATTATCACGTGACATCTTGTGTAGAAATCGTAGAAATCGAAGACGATGAAGCAGAAAAAACAACACAATTATCGGACGAAGATAAAGTTGTTTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAGAAAAAATATCAACCAAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTACGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAATTACGAATGTGTTGATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTGTTTTGCTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATTCAAATCTCACGAACTACTCTACACGCACAAAATAGAAAAGAAGCACTTTACTTACAAGCCTCATCTACGACAAACTGAAGAAACCAACAAAGATGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGATGACGTTTTAGAAACTTTAGACGTCCCAGTTAACAAAATCCACTATCAAGGAACAGACGCAAATAAAGAGAATACCGGCGAACAACTTGAAAATTCTGTTGATACAAAGAAAGAAAAGAAGAAGAGAGGTAGAAAACGGAAATGGCCGACAAATCTGAGTGCGAGAACGAAAAAACCGAGTCTTCAAGTCGACGACGGTTATAAATATCAATGCGAAAGGTGCATCGAAACTTTTATAAATGTTGACGATCTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGACAGGTTTTGCATAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTTTTCCCAAACTTCTCCTTTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCACTCACGAAGGCTGTGAAGCGAGATACACGATACGTTCGGATTTGAAGGATCATATAAGAAAAGCCCACACTAGAGAGAGACCATTCAAATGCAACGTTTGCGATAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGATATGCATGTGATCTCTGTCCTAAACGGTTTTTTAAAGCCTATGATCTCAATAATCACCGAAGGATCCATACCGACGAACGCCCTTACCCTTGCCATGTATGCCGAAGGCAGTTTAGACAGAAAGGAGATCTTAACAAACATCTTAAGACTCAGCATCCTGTTTCAGTTTAA
Protein Sequence: MNTLDNNAIVKVYKIEKNGTASSGMWYGKNSSTEDPISTNNFCPVNVSFDPDILLSNENRLTLNLSQFKNDEYFVKCIKLEDRYDSPSIYVGKTVLNLPTMIRCQNCETIFPTKCQYQRHQCEFNAEKVVLKSDVDSSETGDIPVKYICEVCNKQFVNKNNLVRHQSSHENTQENVCENCNKQFISENRLRIHKENYCKKAGHISKFYRSDVDVWKCKKCYEVFSSLLSANYHVTSCVEIVEIEDDEAEKTTQLSDEDKVVLTNENIHTKEAIDKKNIEKISTKLLLQCEFCNRTYAEKKVLLIHQRKHTTARNYECVDCFKVFDSYPIAAQHWMKKCSEYVNLFCLPKLTYCEYCDRTFKSHELLYTHKIEKKHFTYKPHLRQTEETNKDVDVTVPEDNKNILNKLIDDVLETLDVPVNKIHYQGTDANKENTGEQLENSVDTKKEKKKRGRKRKWPTNLSARTKKPSLQVDDGYKYQCERCIETFINVDDLEEHREKVHASNFTCDECGQVLHNAKALIVHSRAHKMLKPYVCETCGRSFSQTSPFWQHMRFHQGIKPFACTHEGCEARYTIRSDLKDHIRKAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRYACDLCPKRFFKAYDLNNHRRIHTDERPYPCHVCRRQFRQKGDLNKHLKTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: iTF_00912467;