Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387422.1:113649869-113652272[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.02 4.7 9.4 2.3 2 21 103 122 102 123 0.94

2 14 1.4e-06 0.00032 22.5 0.8 1 23 147 169 147 169 0.98

3 14 0.0091 2.1 10.5 1.2 2 23 176 197 176 197 0.95

4 14 0.056 13 8.0 0.2 2 20 216 234 215 236 0.89

5 14 0.0011 0.26 13.3 0.8 2 23 288 309 287 309 0.97

6 14 9.9 2.3e+03 0.9 0.5 1 12 315 326 315 328 0.88

7 14 0.0074 1.7 10.8 3.1 2 22 352 372 351 375 0.88

8 14 0.016 3.7 9.7 0.1 1 23 474 497 474 497 0.97

9 14 0.0014 0.34 13.0 0.1 1 23 501 523 501 523 0.97

10 14 4e-07 9.5e-05 24.2 1.4 1 23 529 551 529 551 0.98

11 14 0.0015 0.35 12.9 1.1 1 23 557 582 557 582 0.96

12 14 0.058 13 8.0 2.9 1 23 588 610 588 610 0.86

13 14 2.4e-05 0.0056 18.6 0.7 1 23 616 638 616 638 0.97

14 14 0.00037 0.086 14.9 6.5 1 23 644 667 644 668 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.02	4.7	9.4	2.3	2	21	103	122	102	123	0.94
2	14	1.4e-06	0.00032	22.5	0.8	1	23	147	169	147	169	0.98
3	14	0.0091	2.1	10.5	1.2	2	23	176	197	176	197	0.95
4	14	0.056	13	8.0	0.2	2	20	216	234	215	236	0.89
5	14	0.0011	0.26	13.3	0.8	2	23	288	309	287	309	0.97
6	14	9.9	2.3e+03	0.9	0.5	1	12	315	326	315	328	0.88
7	14	0.0074	1.7	10.8	3.1	2	22	352	372	351	375	0.88
8	14	0.016	3.7	9.7	0.1	1	23	474	497	474	497	0.97
9	14	0.0014	0.34	13.0	0.1	1	23	501	523	501	523	0.97
10	14	4e-07	9.5e-05	24.2	1.4	1	23	529	551	529	551	0.98
11	14	0.0015	0.35	12.9	1.1	1	23	557	582	557	582	0.96
12	14	0.058	13	8.0	2.9	1	23	588	610	588	610	0.86
13	14	2.4e-05	0.0056	18.6	0.7	1	23	616	638	616	638	0.97
14	14	0.00037	0.086	14.9	6.5	1	23	644	667	644	668	0.97

Sequence Information

Coding Sequence: ATGAACACCCTTAATAATAACATAATTGTAAAAGTATATAAAATAGAAGAAAATGGGACGGCGTCTTCAGGAATGTGGTATGGAAAGAATTCAAGCACCGAAGATCCTATATCTACAAATAACTTTTGTCCAGTAAACGTAAGCTCTGATCCTGATATATTATTATCTAATGAAAACCGATTAACATTGAATTTAAGCCAATTCAAGAACGATGAATATTTTGTTAAGTGTGTTAAATTAGAAGATAGATATGACTCACCATCGATATATGTCGGTAAGATCGGTTTGAATATTCCTACTATGATAAGATGCCAAAATTGTGAGACTAATTTTCCCACTAAATATCGATATCAAAGGCATCAGTGTGAATTTAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGGCGGTATTCCCGTTAAATACATTTGCGAAGTTTGCAATAAACAGTTTGTTAATAAAAATAATTTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAACAATTTATTAGTGAAAATCGTTTGAGGACACACAAAGAAAACCATTGTAAAAAAGCTGGAGACATTTCTAAATTTTACAGAAGCGATGTGGCTGTTTGGAAATGCAAAAAGTGTTATGAAGTATTTTCTTCACCTTTATTAGCAAATTATCACATGACATCTTGTGTAGAAATCGTAGAAATCGAAGACGATGAAGCCGAAAAAACAACACAATTATCGGACGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAGAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTACGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAATTACGAATGTGTTAATTGCTTTGAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTGTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATACAAATCTCACGAACTACTCTACACGCACAAAATAAAAAAGAAGCACTATACTTACAAGCTCCAACTACGAGAAACTGAAGAAACCAACAAAGATGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGATGACGTTTTCAAAGCTTTAGACATCCCAGTTAACAAAATCCACTATCAAGGAACAGAGGCAAATAAAGAGAATACCGGCGAACAACTTGAAAATTCTGTTGATGCAACGGAAAAGAAGAAGAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGCGAGAACGAGTCTTCAAGTCGACGACGGTTATAAATATCAATGCGAAAGGTGCATCGAAACTTTTATAAATGTTGACGATCTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGACAGGTTTTGCATAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGAAGTTAAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTATTCCCAAACTTCTCATCTTTTGATACATATGCGCTTGCATCAAGGGATAAAGCCGTTTGCGTGCCCCCACGAAGGCTGTGAAGCGAGATACACGATACGTTCGCATTTGAAGGATCATATAAGAAGAGCCCACACTAGAGAGAGACCATTCAAATGCAACGTTTGCGATAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGATATGCATGTGATCTCTGTCCTAAACGGTTTTTTAAAGCCTATGATCTCAAAAATCACCGAATGATCCATACCGACGAACGCCCTTACCCTTGCCATGTATGCCGAAAGCAGTTTAGACAGAAAGGAGATCGTAAGAAACATCTTAAGACTCAGCATCATGTTTCAGTTTAA
Protein Sequence: MNTLNNNIIVKVYKIEENGTASSGMWYGKNSSTEDPISTNNFCPVNVSSDPDILLSNENRLTLNLSQFKNDEYFVKCVKLEDRYDSPSIYVGKIGLNIPTMIRCQNCETNFPTKYRYQRHQCEFNAEKVVLKSDVDSSETGGIPVKYICEVCNKQFVNKNNLVRHQSSHENTQENVCENCNKQFISENRLRTHKENHCKKAGDISKFYRSDVAVWKCKKCYEVFSSPLLANYHMTSCVEIVEIEDDEAEKTTQLSDEDKVVLTNENIHTKEAIDKKNIEKISTELLLQCEFCNRTYAEKKVLLIHQRKHTTARNYECVNCFEVFDSYPIAAQHWMKKCSEYVNLFYLPKLTYCEYCDRTYKSHELLYTHKIKKKHYTYKLQLRETEETNKDVDVTVPEDNKNILNKLIDDVFKALDIPVNKIHYQGTEANKENTGEQLENSVDATEKKKRGRKRKWPTNLSARTSLQVDDGYKYQCERCIETFINVDDLEEHREKVHASNFTCDECGQVLHNAKALIVHSRAHKKLKPYVCETCGRSYSQTSHLLIHMRLHQGIKPFACPHEGCEARYTIRSHLKDHIRRAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRYACDLCPKRFFKAYDLKNHRMIHTDERPYPCHVCRKQFRQKGDRKKHLKTQHHVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: -