Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387426.1:47735680-47738038[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0013 0.31 13.1 1.5 2 21 97 116 96 117 0.94

2 14 0.00023 0.053 15.5 1.8 1 23 142 164 142 164 0.98

3 14 0.033 7.7 8.7 0.2 2 20 171 189 171 191 0.92

4 14 0.32 75 5.6 0.2 2 19 211 228 210 231 0.79

5 14 0.0011 0.26 13.4 0.8 2 23 283 304 282 304 0.97

6 14 2.4 5.6e+02 2.9 0.9 1 12 310 321 310 323 0.89

7 14 0.0072 1.7 10.8 5.2 2 22 347 367 346 370 0.89

8 14 0.015 3.6 9.8 0.1 1 23 462 485 462 485 0.97

9 14 0.00027 0.064 15.3 0.2 1 23 489 511 489 511 0.97

10 14 1.3e-07 2.9e-05 25.8 2.3 1 23 517 539 517 539 0.98

11 14 0.031 7.3 8.8 0.2 2 23 546 570 545 570 0.90

12 14 0.056 13 8.0 2.9 1 23 576 598 576 598 0.86

13 14 1.7e-05 0.0039 19.1 1.1 1 23 604 626 604 626 0.96

14 14 0.012 2.9 10.0 6.0 1 23 632 655 632 655 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0013	0.31	13.1	1.5	2	21	97	116	96	117	0.94
2	14	0.00023	0.053	15.5	1.8	1	23	142	164	142	164	0.98
3	14	0.033	7.7	8.7	0.2	2	20	171	189	171	191	0.92
4	14	0.32	75	5.6	0.2	2	19	211	228	210	231	0.79
5	14	0.0011	0.26	13.4	0.8	2	23	283	304	282	304	0.97
6	14	2.4	5.6e+02	2.9	0.9	1	12	310	321	310	323	0.89
7	14	0.0072	1.7	10.8	5.2	2	22	347	367	346	370	0.89
8	14	0.015	3.6	9.8	0.1	1	23	462	485	462	485	0.97
9	14	0.00027	0.064	15.3	0.2	1	23	489	511	489	511	0.97
10	14	1.3e-07	2.9e-05	25.8	2.3	1	23	517	539	517	539	0.98
11	14	0.031	7.3	8.8	0.2	2	23	546	570	545	570	0.90
12	14	0.056	13	8.0	2.9	1	23	576	598	576	598	0.86
13	14	1.7e-05	0.0039	19.1	1.1	1	23	604	626	604	626	0.96
14	14	0.012	2.9	10.0	6.0	1	23	632	655	632	655	0.98

Sequence Information

Coding Sequence: ATGAACACCCTTGGTAATAACACAATTGTAAACGTATATAAAATAGAAGAAAATGGGACGGCGTCTTCAGGAATGTGGTATGGAAAGAATTCAAGCACAAATAACTTTTGTCCAGTTAACGTAAGCTTTGATCCTGATATATTATTATCTAATGAAAACCGATTAACATTGAATTTAAGCCAATTCAAGAACAATGAATATTTTGTTAAGTGTATTAAGTTTGAAGATAGATATGACTCACCATCGATATATGTCGGTAAGACCGTTTTGAATATTCCTACTATGATAAGATGCCAAAATTGTGAGACTATTTTTCCCACTAAATATCAATATCAAAGGCATCAGTGTGAATTTAATGCAGAAAAGGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGATGGCGGTATTCCCGTTAAATACATTTGCGAATTTTGCAATAAACAGTTTGTTAATAAAAATAATACGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTCTGTGAAAATTGCAACAAACAATTTATTAGTGAAAATCGTTTGAGGATACACAAAGAAAACAATTGTAAAAAAGCTGGAGACATTTCTAAATTTTACAGAAGCGATGTGGCTGTTTGGAAATGCAAAAAGTGTTATGAAGTATTTTCTTCACTTTTATCAGCAAATTATCACGTGACATCTTGTGTAGAAATCGTAGAAATCGAAGACGATGAAGCAGAAAAAACAACCCAATTATCGGACGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAAAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTACGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAACTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTGTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATACAAATCTCACGAACACCTCTACACGCACAAAATAAAAAAGAAGCACTATACTTACAAGCTGCATCTACGACAAACTGAAGAAACCAACAAAGATGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGAGGACGTTTTAGAAACTTTAGACGTCCCAGTTAACAAAATCCACTATCAAGGAACAGACGCAAATAAAGAGAATACCGGCGAACAACTTGAAAATTCTGTTGATACAACGGAAAAGAAGAAGAGAGGTAGAAAACGAAAATGGCCGAGTCTTCAAGTCGACGACGGTTATAAATATCAATGCGAAAGGTGCATCGAAACTTTTATAAATGTTGACGATCTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGAAAGGTTTTGCATAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTATTCCCAATCTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCCTTCACGAAGGCTGTGAAGCGAGATACACGGTACGTCCGGATTTGAAGGATCATATAAGAAGAGCCCACACTAGAGAGAGACCATTCAAATGCAACGTTTGCGATAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGACATGCATGTGATCTCTGTCCTAGACGGTTTTTTAGAGCCGATGATCTCAATAATCACCGAAGGATCCATACCGGCGAACGCCCTTACTCTTGCCATGTATGCCGAAGGCAGTTTAGACAGAAACGAGTTCGTAACAAACATCTTAAGACTCAGCATCCTGTTTCAGTTTAA
Protein Sequence: MNTLGNNTIVNVYKIEENGTASSGMWYGKNSSTNNFCPVNVSFDPDILLSNENRLTLNLSQFKNNEYFVKCIKFEDRYDSPSIYVGKTVLNIPTMIRCQNCETIFPTKYQYQRHQCEFNAEKVVLKSDVDSSETDGGIPVKYICEFCNKQFVNKNNTVRHQSSHENTQENVCENCNKQFISENRLRIHKENNCKKAGDISKFYRSDVAVWKCKKCYEVFSSLLSANYHVTSCVEIVEIEDDEAEKTTQLSDEDKVVLTNENIHTKEAIDKKNIKKISTELLLQCEFCNRTYAEKKVLLIHQRKHTTARNYECVNCFKVFDSYPIAAQHWMKKCSEYVNLFYLPKLTYCEYCDRTYKSHEHLYTHKIKKKHYTYKLHLRQTEETNKDVDVTVPEDNKNILNKLIEDVLETLDVPVNKIHYQGTDANKENTGEQLENSVDTTEKKKRGRKRKWPSLQVDDGYKYQCERCIETFINVDDLEEHREKVHASNFTCDECGKVLHNAKALIVHSRAHKMLKPYVCETCGRSYSQSSHLWQHMRFHQGIKPFACLHEGCEARYTVRPDLKDHIRRAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRHACDLCPRRFFRADDLNNHRRIHTGERPYSCHVCRRQFRQKRVRNKHLKTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: -