Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387422.1:96451121-96453320[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.023 5.3 9.2 3.6 2 21 97 116 96 117 0.94

2 12 1.3e-06 0.00031 22.6 0.8 1 23 141 163 141 163 0.98

3 12 0.028 6.5 9.0 0.3 2 20 170 188 170 190 0.92

4 12 0.14 32 6.8 0.2 2 19 210 227 209 230 0.84

5 12 0.0011 0.25 13.4 0.8 2 23 282 303 281 303 0.97

6 12 2.3 5.5e+02 2.9 0.9 1 12 309 320 309 322 0.89

7 12 0.0019 0.44 12.6 2.8 2 20 346 364 345 369 0.89

8 12 0.015 3.5 9.8 0.1 1 23 469 492 469 492 0.97

9 12 0.00026 0.062 15.3 0.2 1 23 496 518 496 518 0.97

10 12 0.0086 2 10.6 0.3 5 23 528 546 527 546 0.95

11 12 0.0044 1 11.5 0.5 1 23 552 577 552 577 0.95

12 12 0.055 13 8.0 2.1 1 10 583 592 583 605 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.023	5.3	9.2	3.6	2	21	97	116	96	117	0.94
2	12	1.3e-06	0.00031	22.6	0.8	1	23	141	163	141	163	0.98
3	12	0.028	6.5	9.0	0.3	2	20	170	188	170	190	0.92
4	12	0.14	32	6.8	0.2	2	19	210	227	209	230	0.84
5	12	0.0011	0.25	13.4	0.8	2	23	282	303	281	303	0.97
6	12	2.3	5.5e+02	2.9	0.9	1	12	309	320	309	322	0.89
7	12	0.0019	0.44	12.6	2.8	2	20	346	364	345	369	0.89
8	12	0.015	3.5	9.8	0.1	1	23	469	492	469	492	0.97
9	12	0.00026	0.062	15.3	0.2	1	23	496	518	496	518	0.97
10	12	0.0086	2	10.6	0.3	5	23	528	546	527	546	0.95
11	12	0.0044	1	11.5	0.5	1	23	552	577	552	577	0.95
12	12	0.055	13	8.0	2.1	1	10	583	592	583	605	0.82

Sequence Information

Coding Sequence: ATGAACACCCTTGATAATAACACAATTGTAAAAGTATATAAAATAGAAAAAGATGGGACGGCGTCTTCAGGAATGTGGTATGGAAAGAATTCAAGCAGAAATAACATTTATCCAGTAAACGTAAGCTTTGATCCTGATATATTATTATCTAATGAAAACCGATTAACATTGAATTTAAGCCAATTCAAGAACGATGAATATTTTGTTAAGTGTAATAAGTTTGAAGAAAGATATGATTCACCATCGATATATGTCAGTAAGACCTTTTTGAATCTTCCTACTATGATAAGATGCCAAAATTGTGAGACTATTTTTCCCACTAAATGTCAATATCAAAGGCATCAGTGTGAATTTAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGGCGGTATTCCCGTTAAATACATTTGCGAAGTTTGCAATAAACAGTTTGTTAATAAAAATAATTTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAACAATTTATTAGTGAAAATCGTTTAAGGGTACACAAAGAAAACTATTGTAAAAAAGCTGGAGACATATCTAAATTTTACAGAAGCGATGTGGCTGTTTGGAAATGCAAAAAGTGTTATGAAGTATTTTCTTCACCTTTATCAGCAAATTATCACGTGACATCTTGTGTAGAAATCGTAGAAATCGAAGACGATGAAGCAGAAAAAACAACACAATTATCGGACGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAGAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTACGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAATTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTGTTTTGCTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATTCAAATCTCACGAACTACTCTACACGCACAAAATACAAAAGAAGCACTATACTCACAAGCTCCAAACTGAAGAAACCAACAAAAATGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGATGACGTTTTAGAAACTTTAGACGTCCCAGTTAACAAAATCCACTATCAAGGAACAAACGCAAATAAAGAGAATACCGGCGAACAACTTGAAAATTCTGTTGATACAAAGAAAGAAAAGAAGAAGAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGCGAGAACGAAAAAACCGAGTCTTCAAGTCGACGACGGTTATAAATATCAATGCGAAAGGTGCATCGAAACTTTTATAAATGTTGACGATCTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGAAAGGTTTTGCATAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAACCGTATGTTTATGAAACTTGCGGCCGAAGCTATTCCAAAACTTCTCCTTTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCACTCACGAAGGCTGTGAAGCGAGATACACGATACGTTCGGATTTGAAGGATCATATAAGAAAAGCCCACACTAGAGAGAGACCATTCAAATGCAACATTTGCGATAAATGTTTTTTAACTGGTCCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGATATGCATGTGATGTAAGTATATATAGCTATATTCTTTATTTATTTATTTATTTATTTATTTACGGGCAAGCCCAATTACATATAAAAAATAAGTGA
Protein Sequence: MNTLDNNTIVKVYKIEKDGTASSGMWYGKNSSRNNIYPVNVSFDPDILLSNENRLTLNLSQFKNDEYFVKCNKFEERYDSPSIYVSKTFLNLPTMIRCQNCETIFPTKCQYQRHQCEFNAEKVVLKSDVDSSETGGIPVKYICEVCNKQFVNKNNLVRHQSSHENTQENVCENCNKQFISENRLRVHKENYCKKAGDISKFYRSDVAVWKCKKCYEVFSSPLSANYHVTSCVEIVEIEDDEAEKTTQLSDEDKVVLTNENIHTKEAIDKKNIEKISTELLLQCEFCNRTYAEKKVLLIHQRKHTTARNYECVNCFKVFDSYPIAAQHWMKKCSEYVNLFCLPKLTYCEYCDRTFKSHELLYTHKIQKKHYTHKLQTEETNKNVDVTVPEDNKNILNKLIDDVLETLDVPVNKIHYQGTNANKENTGEQLENSVDTKKEKKKRGRKRKWPTNLSARTKKPSLQVDDGYKYQCERCIETFINVDDLEEHREKVHASNFTCDECGKVLHNAKALIVHSRAHKMLKPYVYETCGRSYSKTSPFWQHMRFHQGIKPFACTHEGCEARYTIRSDLKDHIRKAHTRERPFKCNICDKCFLTGPVYYQHRLIHTNDRRYACDVSIYSYILYLFIYLFIYGQAQLHIKNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: -