Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387422.1:36210291-36212761[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 2.3 5.4e+02 2.9 1.3 2 21 38 57 37 58 0.93

2 14 3.8e-06 0.00089 21.1 1.5 1 23 83 105 83 105 0.98

3 14 0.012 2.8 10.1 0.6 2 20 112 130 112 132 0.92

4 14 0.13 31 6.8 0.3 2 19 152 169 151 172 0.84

5 14 0.001 0.23 13.5 0.8 2 23 224 245 223 245 0.97

6 14 2.2 5.2e+02 3.0 0.9 1 12 251 262 251 264 0.89

7 14 0.00081 0.19 13.8 1.6 2 20 288 306 287 311 0.90

8 14 6.5 1.5e+03 1.5 0.0 9 23 421 436 414 436 0.91

9 14 0.0016 0.37 12.9 0.1 1 23 440 462 440 462 0.97

10 14 1.6e-07 3.8e-05 25.4 0.7 1 23 468 490 468 490 0.98

11 14 0.015 3.5 9.8 0.1 1 23 496 521 496 521 0.96

12 14 4.6 1.1e+03 2.0 2.3 1 23 527 549 527 549 0.83

13 14 3.3e-05 0.0077 18.2 0.3 1 23 555 577 555 577 0.98

14 14 5.9e-05 0.014 17.4 3.6 1 23 583 606 583 606 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	2.3	5.4e+02	2.9	1.3	2	21	38	57	37	58	0.93
2	14	3.8e-06	0.00089	21.1	1.5	1	23	83	105	83	105	0.98
3	14	0.012	2.8	10.1	0.6	2	20	112	130	112	132	0.92
4	14	0.13	31	6.8	0.3	2	19	152	169	151	172	0.84
5	14	0.001	0.23	13.5	0.8	2	23	224	245	223	245	0.97
6	14	2.2	5.2e+02	3.0	0.9	1	12	251	262	251	264	0.89
7	14	0.00081	0.19	13.8	1.6	2	20	288	306	287	311	0.90
8	14	6.5	1.5e+03	1.5	0.0	9	23	421	436	414	436	0.91
9	14	0.0016	0.37	12.9	0.1	1	23	440	462	440	462	0.97
10	14	1.6e-07	3.8e-05	25.4	0.7	1	23	468	490	468	490	0.98
11	14	0.015	3.5	9.8	0.1	1	23	496	521	496	521	0.96
12	14	4.6	1.1e+03	2.0	2.3	1	23	527	549	527	549	0.83
13	14	3.3e-05	0.0077	18.2	0.3	1	23	555	577	555	577	0.98
14	14	5.9e-05	0.014	17.4	3.6	1	23	583	606	583	606	0.98

Sequence Information

Coding Sequence: ATGGAATTTGCAATCTTCATTATCATTGGATGGTATAAAAAGTTCAGTGCTGTAATTGGTCTAATATATGGGGTGCTAATACTATCTCTTTCTAAGCTAATGTGTGAAACAAGATGCGATAACTGTGACGGAAATATGAATACTGAATATCAATATCAAAGGCATCAGTGTGAATTTAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGATGGCGGTATTCCCGTTAAATACATTTGCGAATTTTGCAATAAACAGTTTGTTAATAAAAATAATTTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAACATTGCAACAAACAATTTATTAGTGAAAATCGTTTAAGGATACACAAAGAAAACTATTGTAAAAAAGCTGGACACATTTCTAAATTTTACAGAAGCGATGTGGATGTTTGGAAATGCAAGAAGTGTTATGAAGTATTTTCTTCACCTTTATCAGCAAATTATCACACGACATCTTGTGTAGAAATCGTAGAAATCGAAGAAGATGAAGCAGAAAAAACAACACAATTATCGGACGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAGAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTACGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAATTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTGTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATTCAAATCTCACGAACTACTCTACACGCACAAAATAGAAAATAAGCACTTTACTTACAAGCCTCATCTACGACAAACTGAAGAAACCAACAAAGATGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGACGACGATTTAAAAACTTTAGACGTCCCAGTTAACAAAATCCACTATCAAGGAACAGACGCAAATAAAGAGAATACCGGCGAACAACTTGAAAATTCTGTTGATACAACGGAAAAGGAGAAGAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGCGAGAACGATAAAACCGAGTCTTCAAGTCGACGACGGTTATAAATATCAATGCGAAAGGAGCATCGAAACTTTTATAAATGTTGACGATCTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGACAGGTTTTGCATAACGCCACAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTATACCAAACCTTCTCAACTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCCCTCACGAAGGCTGTGAAGCGAGATACACGATACGTCCGGATTTGAAGGATCATATAAGAAAAGCCCACACTAGAGAGAGACCATTCAAATGCATCGTTTGCGATAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATGCCAATGACAGAAGATATGCATGTGATCTCTGTCCTAAACGGTTTTTTAGAGCCGATGCTGTCAAAAATCACCGAAGGATCCATACCGACGAACGCCCTTACCCTTGCCATGTATGCCGAAAGCAGTTTAGACAGAAAGGAGATCGTAACAAACATGTTAGGACTCAGCATCCTGTTTCAGTTTAA
Protein Sequence: MEFAIFIIIGWYKKFSAVIGLIYGVLILSLSKLMCETRCDNCDGNMNTEYQYQRHQCEFNAEKVVLKSDVDSSETDGGIPVKYICEFCNKQFVNKNNLVRHQSSHENTQENVCEHCNKQFISENRLRIHKENYCKKAGHISKFYRSDVDVWKCKKCYEVFSSPLSANYHTTSCVEIVEIEEDEAEKTTQLSDEDKVVLTNENIHTKEAIDKKNIEKISTELLLQCEFCNRTYAEKKVLLIHQRKHTTARNYECVNCFKVFDSYPIAAQHWMKKCSEYVNLFYLPKLTYCEYCDRTFKSHELLYTHKIENKHFTYKPHLRQTEETNKDVDVTVPEDNKNILNKLIDDDLKTLDVPVNKIHYQGTDANKENTGEQLENSVDTTEKEKRGRKRKWPTNLSARTIKPSLQVDDGYKYQCERSIETFINVDDLEEHREKVHASNFTCDECGQVLHNATALIVHSRAHKMLKPYVCETCGRSYTKPSQLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKAHTRERPFKCIVCDKCFLTGSVYYQHRLIHANDRRYACDLCPKRFFRADAVKNHRRIHTDERPYPCHVCRKQFRQKGDRNKHVRTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: iTF_00912502;