Basic Information

Insect: Lochmaea capreae
Gene Symbol: topi
Assembly: GCA_949126875.1
Location: OX421409.1:4012750-4015499[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.0023 0.46 12.7 2.1 2 21 103 122 102 123 0.94

2 13 6.1e-06 0.0013 20.7 1.2 1 23 148 170 148 170 0.98

3 13 0.0088 1.8 10.8 2.1 2 23 177 198 177 198 0.95

4 13 0.23 46 6.4 0.2 2 19 217 234 216 237 0.82

5 13 0.0029 0.6 12.3 0.9 2 23 290 311 289 311 0.97

6 13 0.0025 0.5 12.5 3.4 2 22 354 374 353 377 0.88

7 13 0.0018 0.37 12.9 0.2 1 23 482 505 482 505 0.96

8 13 0.0078 1.6 11.0 0.2 1 23 509 531 509 531 0.97

9 13 7.3e-07 0.00015 23.6 2.4 1 23 537 559 537 559 0.98

10 13 0.021 4.2 9.6 0.1 1 23 565 590 565 590 0.96

11 13 0.071 15 7.9 2.9 1 23 596 618 596 618 0.86

12 13 4.5e-06 0.00092 21.1 0.3 1 23 624 646 624 646 0.98

13 13 3e-06 0.00061 21.7 2.2 1 23 652 675 652 675 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.0023	0.46	12.7	2.1	2	21	103	122	102	123	0.94
2	13	6.1e-06	0.0013	20.7	1.2	1	23	148	170	148	170	0.98
3	13	0.0088	1.8	10.8	2.1	2	23	177	198	177	198	0.95
4	13	0.23	46	6.4	0.2	2	19	217	234	216	237	0.82
5	13	0.0029	0.6	12.3	0.9	2	23	290	311	289	311	0.97
6	13	0.0025	0.5	12.5	3.4	2	22	354	374	353	377	0.88
7	13	0.0018	0.37	12.9	0.2	1	23	482	505	482	505	0.96
8	13	0.0078	1.6	11.0	0.2	1	23	509	531	509	531	0.97
9	13	7.3e-07	0.00015	23.6	2.4	1	23	537	559	537	559	0.98
10	13	0.021	4.2	9.6	0.1	1	23	565	590	565	590	0.96
11	13	0.071	15	7.9	2.9	1	23	596	618	596	618	0.86
12	13	4.5e-06	0.00092	21.1	0.3	1	23	624	646	624	646	0.98
13	13	3e-06	0.00061	21.7	2.2	1	23	652	675	652	675	0.98

Sequence Information

Coding Sequence: ATGAACACCCTTGATAATAACACAATTATTAACGTAtataaaattgaagaaaatgggATGGCGACTTCAGGAATGTGGTATGAAATGAATTCAAGCACCAAAGATCCTATATCTACAAATAACTTTTGTCCAGTAAATGTAAGCTTTGATCCCAATATATTATTATCTAATGAAAATCGATTTACGTTGAATTTACGCCAATTCGAGAACAATGAAGATTTTGTTAAGTGCATTAAATTTGAAGATACATATGACTCACCATCGATAAACGTGGGTAAGGCCATTTTGAATATTCCAACTATGATAAGATGCCAAAATTGTGAGACTAATTTTCCCACTAAATATCAATATCAAAGGCATCAGTGTGAATTTAATGccgaaaaagttgttttaaaatCGGATGTTGATTCTAATGAAGTAGATACTGGTATTCCCGTTAAATACATTTGCGAATTTTGCAACAAACAGTTTGTTAATAGAAATAATTTGGCTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAACATTGCAACAAGCAATTCATTAGTGAAAATCGTTTGAGGATACACAAAGAAAACCATTGTAAAAAAGCTGGAGACATTTCTAAATTTTACAGAAGTGATGTGGCTGTTTGGAAATGCAAAAAGTGTTATGAAGTGTTTTCTTCACCTTTAACAGCAAATTATCACGTGACATCTTGTGTAGAAATCGTAGAAATAATCGAAGACGAAGCAGAAAAATCAACACATTCATCGGACGAAGATAACAAAGTTGACTTGAATTACGAAAATATTTACACAAAAGAAGCAATTGACgagaaaaatatagaaaaagtaTTAACCGAGCTCCTGCTACAATGTGAATTCTGTAACAGAACTTACGCTGAAAAAAATGTGCTGCTTATGCACCAAAGAAAACACACTACAGCCAGAAATTACGAATGCGTTAATTGCTTTCAAGTTTTTGATTCTTATCCGATAGCTGCTCAGCACTGGatgaaaaaatgttcagaatacgTAAGTCTGTTTTACTTACCGAAATTAACTTACTGTGAATATTGCGACCGAACATTTAAATCTCACGAACTACTCTacacacacaaaattaaaaaaaagcattACACTTCCAAGCTCCATCTACAGCCAAGGGAAGAAACCAACAAAGATGTCGGTGTTACAGTTCCCGAAAAGTGTGTCGATAACAAAGAAATCCTCAACAAACTAATCGAGGACGTTTTAAAAACTTTAGATGTCCCAGTTAACAAAATCAACTATCAAGGAATAGACGCGAATAAAGAGAATAACGgtgaacaaattaaaaattgcgTTGATACTACGGAAAAGAAGAAGAGAGGAAGAAAACGTAAATGGCCGAAAAATCAATGTGTGAGAACGAAAAAACTCAGCCTGGAAGTCGACGATGGTTATAAATATCAATGCGAGAGGTGCACTGAAACTTTTATAAACGTTGAAGATCTCGAGGGACATCGGGAGAAGGAGCATGCTTCGAATTTCACTTGTGATGAATGCGGACAGattttgCATAGCGCCAAAGCGTTGATGATACACAGTCGTGCTCATAAAATGTTGAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTATTCTCAAACTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGAATAAAGCCTTTTGCGTGCCCGCACGAGGGATGTGAAGCGAGATACACGATACGACCGGATTTGAAGGATCATATAAGAAAAGCCCACACTAGAGAGAGACCGTTCAAATGCAACGTGTGCGATAAATGTTTTTTAACTGGTTCTGTCTATTACCAACATCGTTTGATACATACCAATGACAGAAGATATGCATGTGATCTGTGTCCAAAACGGTTTTTTAGAGCCGATGCTCTGAATAATCACCGAAGGATCCATACCGACGAACGTCCTTATCCTTGCCATGTATGCGGAAGGGAATTTAGACAGAAGGGAGATCGTAACAAACATCTTAGGACTCAGCACCCGGATACGgttttagtttaa
Protein Sequence: MNTLDNNTIINVYKIEENGMATSGMWYEMNSSTKDPISTNNFCPVNVSFDPNILLSNENRFTLNLRQFENNEDFVKCIKFEDTYDSPSINVGKAILNIPTMIRCQNCETNFPTKYQYQRHQCEFNAEKVVLKSDVDSNEVDTGIPVKYICEFCNKQFVNRNNLARHQSSHENTQENVCEHCNKQFISENRLRIHKENHCKKAGDISKFYRSDVAVWKCKKCYEVFSSPLTANYHVTSCVEIVEIIEDEAEKSTHSSDEDNKVDLNYENIYTKEAIDEKNIEKVLTELLLQCEFCNRTYAEKNVLLMHQRKHTTARNYECVNCFQVFDSYPIAAQHWMKKCSEYVSLFYLPKLTYCEYCDRTFKSHELLYTHKIKKKHYTSKLHLQPREETNKDVGVTVPEKCVDNKEILNKLIEDVLKTLDVPVNKINYQGIDANKENNGEQIKNCVDTTEKKKRGRKRKWPKNQCVRTKKLSLEVDDGYKYQCERCTETFINVEDLEGHREKEHASNFTCDECGQILHSAKALMIHSRAHKMLKPYVCETCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRYACDLCPKRFFRADALNNHRRIHTDERPYPCHVCGREFRQKGDRNKHLRTQHPDTVLV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00736063;
80% Identity: -