Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387426.1:47869662-47872058[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0014 0.32 13.1 1.5 2 21 97 116 96 117 0.94

2 14 4.2e-06 0.00099 21.0 1.5 1 23 142 164 142 164 0.98

3 14 0.0092 2.2 10.5 0.8 2 23 171 192 171 192 0.95

4 14 0.14 34 6.7 0.2 2 19 211 228 210 231 0.84

5 14 0.00027 0.063 15.3 1.0 2 23 283 304 282 304 0.97

6 14 2.5 5.7e+02 2.8 0.9 1 12 310 321 310 323 0.89

7 14 0.0074 1.7 10.8 5.2 2 22 347 367 346 370 0.89

8 14 0.018 4.2 9.6 0.1 1 23 472 495 472 495 0.97

9 14 0.0014 0.34 13.0 0.1 1 23 499 521 499 521 0.97

10 14 1.3e-07 3e-05 25.7 2.3 1 23 527 549 527 549 0.98

11 14 0.066 16 7.8 0.3 2 23 556 580 555 580 0.90

12 14 0.057 13 8.0 2.9 1 23 586 608 586 608 0.86

13 14 1.1e-05 0.0026 19.6 0.9 1 23 614 636 614 636 0.96

14 14 0.032 7.4 8.8 4.3 1 23 642 665 642 665 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0014	0.32	13.1	1.5	2	21	97	116	96	117	0.94
2	14	4.2e-06	0.00099	21.0	1.5	1	23	142	164	142	164	0.98
3	14	0.0092	2.2	10.5	0.8	2	23	171	192	171	192	0.95
4	14	0.14	34	6.7	0.2	2	19	211	228	210	231	0.84
5	14	0.00027	0.063	15.3	1.0	2	23	283	304	282	304	0.97
6	14	2.5	5.7e+02	2.8	0.9	1	12	310	321	310	323	0.89
7	14	0.0074	1.7	10.8	5.2	2	22	347	367	346	370	0.89
8	14	0.018	4.2	9.6	0.1	1	23	472	495	472	495	0.97
9	14	0.0014	0.34	13.0	0.1	1	23	499	521	499	521	0.97
10	14	1.3e-07	3e-05	25.7	2.3	1	23	527	549	527	549	0.98
11	14	0.066	16	7.8	0.3	2	23	556	580	555	580	0.90
12	14	0.057	13	8.0	2.9	1	23	586	608	586	608	0.86
13	14	1.1e-05	0.0026	19.6	0.9	1	23	614	636	614	636	0.96
14	14	0.032	7.4	8.8	4.3	1	23	642	665	642	665	0.98

Sequence Information

Coding Sequence: ATGAACACCCTTGGTAATAACACAATTGTAAAGGTATATAAAATAGAAGAAAATGGGACGGCGTCTTCAGGAATGTGGTATGGAAAGAATTCAAGCACAAATAACTTTTGTCCAGTTAACGTAAGCTTTGATCCTGATATATTATTATCTAATGAAAACCGATTAACATTGAATTTAAGCCAATTCAAGAACAATGAATATTTTGTTAAGTGTATTAAGTTTGAAGATAGATATGACTCACCATCGATATATGTCGGTAAGACCGTTTTGAATATTCCTATTATGATAAGATGCCAAAATTGTGAGACTATTTTTCCCACTAAATATCAATATCAAAGGCATCAGTGTGAATATAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGATGGCGGTATTCCCGTTAAATACATTTGCGAATTTTGCAATAAACAGTTTGTTAATAAAAATAATTTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAACAATTTATTAGTGAAAATCGTTTGAGGATACACAAAGAAAACCATTGTAAAAAAGGTGGAGACATTTCTAAATTTTACAGAAGCGATGTGGCTGTTTGGAAATGCAAAAAGTGTTATGAAGTATTTTCTTCACCTTTATCAGCAAATTATCACGTGACATCTTGTGTAGAAATCGTAGAAATCGAAGACGATGAAGCAGAAAAAACAACACAATTATCGGACGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGATGCAATTGACAAGAAAAACATAGAAAAAATATCAACCGAGCTTCTACTACAATGTGAATTTTGTAACAGAACTTTCGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAATTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTGTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATACAAATCTCACGAACACCTCTACACGCACAAAATAAAAAAGAAGCACTATACTTACAAGCTCCATATACGACAAACTGAAGAAACCAACAAAGATGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGACGACGTTTTAGAAACTTTAGACGTCCCAGTTAACAAAATCCACTGTCAAGGAACAGACGCAAATAAAGAGAATACCGGCGAACAACTTGAAAATTCTGTTGATACAACGGAAAAGAAGAAGAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGCGAGAACGGAAAAACCGAGTCTTCAAGTCGACGACGGTTATAAATATCAATGCGAAAGGTGCATCGAAACTTTTATAAATGTTGATGAACTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGACAGGTTTTGCATAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTATTCCCAATCTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCCTTCACGAAGGCTGTGAAGCGAGATATACGTTACGTCCGGATTTGAAGGATCATATAAGAAAAGCCCACACTAGAGAGAGACCATTCAAATGCAACGTTTGCGATAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGACATGCATGTGATCTCTGTCCTAAACGGTTTTTTAGAGCCGATGCTCTCAATAATCACCGAAGGATCCATACCGACGAACGACCTTACCCTTGCCATGTATGCCGAAGGCAGTTTAGAGAGAAACGAGTTCGTAACAAACATCTTAAGACTCAGCATCCTGTTTCAGTTTAA
Protein Sequence: MNTLGNNTIVKVYKIEENGTASSGMWYGKNSSTNNFCPVNVSFDPDILLSNENRLTLNLSQFKNNEYFVKCIKFEDRYDSPSIYVGKTVLNIPIMIRCQNCETIFPTKYQYQRHQCEYNAEKVVLKSDVDSSETDGGIPVKYICEFCNKQFVNKNNLVRHQSSHENTQENVCENCNKQFISENRLRIHKENHCKKGGDISKFYRSDVAVWKCKKCYEVFSSPLSANYHVTSCVEIVEIEDDEAEKTTQLSDEDKVVLTNENIHTKDAIDKKNIEKISTELLLQCEFCNRTFAEKKVLLIHQRKHTTARNYECVNCFKVFDSYPIAAQHWMKKCSEYVNLFYLPKLTYCEYCDRTYKSHEHLYTHKIKKKHYTYKLHIRQTEETNKDVDVTVPEDNKNILNKLIDDVLETLDVPVNKIHCQGTDANKENTGEQLENSVDTTEKKKRGRKRKWPTNLSARTEKPSLQVDDGYKYQCERCIETFINVDELEEHREKVHASNFTCDECGQVLHNAKALIVHSRAHKMLKPYVCETCGRSYSQSSHLWQHMRFHQGIKPFACLHEGCEARYTLRPDLKDHIRKAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRHACDLCPKRFFRADALNNHRRIHTDERPYPCHVCRRQFREKRVRNKHLKTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: -