Basic Information

Insect: Lochmaea crataegi
Gene Symbol: topi
Assembly: GCA_947563755.1
Location: OX387426.1:47920933-47923332[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0014 0.32 13.1 1.5 2 21 97 116 96 117 0.94

2 14 4.2e-06 0.00099 21.0 1.5 1 23 142 164 142 164 0.98

3 14 0.033 7.8 8.7 0.2 2 20 171 189 171 191 0.92

4 14 0.14 34 6.7 0.2 2 19 211 228 210 231 0.84

5 14 0.00027 0.063 15.3 1.0 2 23 284 305 283 305 0.97

6 14 2.5 5.8e+02 2.8 0.9 1 12 311 322 311 324 0.89

7 14 0.001 0.24 13.4 3.8 2 22 348 368 347 371 0.89

8 14 0.0011 0.27 13.3 0.1 1 23 473 496 473 496 0.97

9 14 0.00028 0.065 15.2 0.2 1 23 500 522 500 522 0.97

10 14 1.3e-07 3e-05 25.7 2.3 1 23 528 550 528 550 0.98

11 14 0.11 26 7.1 0.2 2 23 557 581 556 581 0.89

12 14 0.057 13 8.0 2.9 1 23 587 609 587 609 0.86

13 14 1.7e-05 0.004 19.1 1.1 1 23 615 637 615 637 0.96

14 14 0.013 3 10.0 6.0 1 23 643 666 643 666 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0014	0.32	13.1	1.5	2	21	97	116	96	117	0.94
2	14	4.2e-06	0.00099	21.0	1.5	1	23	142	164	142	164	0.98
3	14	0.033	7.8	8.7	0.2	2	20	171	189	171	191	0.92
4	14	0.14	34	6.7	0.2	2	19	211	228	210	231	0.84
5	14	0.00027	0.063	15.3	1.0	2	23	284	305	283	305	0.97
6	14	2.5	5.8e+02	2.8	0.9	1	12	311	322	311	324	0.89
7	14	0.001	0.24	13.4	3.8	2	22	348	368	347	371	0.89
8	14	0.0011	0.27	13.3	0.1	1	23	473	496	473	496	0.97
9	14	0.00028	0.065	15.2	0.2	1	23	500	522	500	522	0.97
10	14	1.3e-07	3e-05	25.7	2.3	1	23	528	550	528	550	0.98
11	14	0.11	26	7.1	0.2	2	23	557	581	556	581	0.89
12	14	0.057	13	8.0	2.9	1	23	587	609	587	609	0.86
13	14	1.7e-05	0.004	19.1	1.1	1	23	615	637	615	637	0.96
14	14	0.013	3	10.0	6.0	1	23	643	666	643	666	0.98

Sequence Information

Coding Sequence: ATGAACACCCTTGGTAATAACACAATTGTAAACGTATATAAAATAGAAGAAAATGGGACGGCGTCTTCAGGAATGTGGTATGGAAAGAATTCAAGCACAAATAACTTTTGTCCAGTAAACGTAAGCTTTGATCCTGATATATTATTATCTAATGAAAACCGATTAACATTGAATTTAAGCCAATTCAAGAACAATGAATATTTTGTTAAGTGTATTAAGTTTGAAGATAGATATGACTCACCATCGATATATGTCGGTAAGACCGTTTTGAATATTCCTACTATGATAAGATGCCAAAATTGTGAGACTATTTTTCCCACTAAATATCAATATCAAAGGCATCAGTGTGAATATAATGCAGAAAAAGTTGTTTTAAAATCGGATGTTGATTCTAGTGAAACTGATGGCGGTATTCTCGTTAAATACATTTGCGAATTTTGCAATAAACAGTTTGTTAATAAAAATAATTTGGTTCGTCACCAGTCTAGCCACGAAAATACACAAGAAAATGTGTGTGAAAATTGCAACAAACAATTTATTAGTGAAAATCGTTTGAGGATACACAAAGAAAACAATTGTAAAAAAGGTGGAGACATTTCTAAATTTTACAGAAGCGATGTGGCTGTTTGGAAATGCAAAAAGTGTTATGAAGTATTTTCTTCACCTTTATCAGCAAATTATCACGTGACATCTTGTGTAGAAATCGTAGAAATCGAAGACGATGAAGCAGAAAAAACAATAACACAATTATCGGACGAAGATAAAGTTGTCTTGACTAACGAAAATATTCACACCAAAGAAGCAATTGACAAGAAAAACATAGAAAAAATATCAACCGAGTTTCTACTACAATGTGAATTTTGTAACAGAACTTTCGCCGAAAAAAAGGTTCTGCTTATACACCAAAGGAAACACACTACAGCCAGAAACTACGAATGTGTTAATTGCTTTAAAGTTTTCGATTCTTATCCAATAGCCGCCCAACATTGGATGAAAAAGTGTTCGGAATACGTAAATCTGTTTTACTTGCCAAAATTAACTTACTGTGAATATTGCGACAGAACATTCAAATCTCACGAACAACTCTACACGCACAAAATAAAAAAGAAGCACTATACTTACAAGCTGCATCTACGACAAACTGAAGAAACCAACAAAGATGTCGATGTTACAGTTCCCGAAGATAACAAAAATATCCTCAACAAACTAATCGAGGACGTTTTAGAAACTTTAGACGTCCCAGTTAACAAAATCCACGATCAAGGAACAGACGCAAATAAAGAGAATACCGGCGAACAGCTTGAAAATTCTGTTGATACCACGGAAAAGAAGAAGAGAGGTAGAAAACGAAAATGGCCGACAAATCTGAGTGCGAGAACGAAAAAACCGAGTCTTCAAGTCGACGACGGTTATAAATATCAATGCGAAAGGTGCGTCGAAACTTTTATAAATGTTGACGATCTTGAGGAACATCGGGAGAAGGTACATGCTTCGAATTTCACTTGTGATGAATGTGGAAAGGTTTTGCATAACGCCAAAGCTTTGATAGTACACAGTCGTGCTCATAAGATGTTGAAACCGTATGTTTGTGAAACTTGCGGCCGAAGCTATTCCCAATCTTCTCATCTTTGGCAACATATGCGCTTCCATCAAGGGATAAAGCCGTTTGCGTGCCTTCACGAAGGCTGTGAAGCGAGATACACGATACGTCCGGATTTGAAGGATCATATAAGAAGAGCCCACACTAGAGAGAGACCATTCAAATGCAACGTTTGCGATAAATGTTTTTTAACTGGTTCTGTTTATTACCAACACCGTTTGATACATACCAATGACAGAAGACATGCATGTGATCTCTGTCCTAGACGGTTTTTTAGAGCCGATGATCTCAATAATCACCGAAGGATCCATACCGGCGAACGCCCTTACTCTTGTCATGTATGCCGAAGGCAGTTTAGACAGAAACGAGTTCGTAACAAACATCTTAAGACTCAGCATCCTGTTTCAGTTTAA
Protein Sequence: MNTLGNNTIVNVYKIEENGTASSGMWYGKNSSTNNFCPVNVSFDPDILLSNENRLTLNLSQFKNNEYFVKCIKFEDRYDSPSIYVGKTVLNIPTMIRCQNCETIFPTKYQYQRHQCEYNAEKVVLKSDVDSSETDGGILVKYICEFCNKQFVNKNNLVRHQSSHENTQENVCENCNKQFISENRLRIHKENNCKKGGDISKFYRSDVAVWKCKKCYEVFSSPLSANYHVTSCVEIVEIEDDEAEKTITQLSDEDKVVLTNENIHTKEAIDKKNIEKISTEFLLQCEFCNRTFAEKKVLLIHQRKHTTARNYECVNCFKVFDSYPIAAQHWMKKCSEYVNLFYLPKLTYCEYCDRTFKSHEQLYTHKIKKKHYTYKLHLRQTEETNKDVDVTVPEDNKNILNKLIEDVLETLDVPVNKIHDQGTDANKENTGEQLENSVDTTEKKKRGRKRKWPTNLSARTKKPSLQVDDGYKYQCERCVETFINVDDLEEHREKVHASNFTCDECGKVLHNAKALIVHSRAHKMLKPYVCETCGRSYSQSSHLWQHMRFHQGIKPFACLHEGCEARYTIRPDLKDHIRRAHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRHACDLCPRRFFRADDLNNHRRIHTGERPYSCHVCRRQFRQKRVRNKHLKTQHPVSV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00736063;
90% Identity: iTF_00912471;
80% Identity: -