Dleo003549.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila leonis
Gene Symbol
-
Assembly
GCA_035045365.1
Location
JAWNPC010000199.1:62575-66491[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.00045 0.034 14.8 0.1 1 23 161 184 161 184 0.96
2 14 0.00022 0.017 15.8 2.3 2 23 233 255 232 255 0.97
3 14 0.014 1 10.2 0.9 1 23 361 384 361 384 0.93
4 14 0.51 38 5.2 3.2 2 23 433 455 432 455 0.96
5 14 0.0035 0.27 12.0 0.5 1 23 525 548 525 548 0.88
6 14 2.2 1.6e+02 3.2 0.1 2 14 567 579 566 591 0.85
7 14 0.00075 0.056 14.1 3.3 2 23 599 621 599 621 0.96
8 14 0.002 0.15 12.8 0.1 1 23 720 743 720 743 0.95
9 14 0.00045 0.034 14.8 0.2 1 23 795 818 795 818 0.93
10 14 0.0013 0.095 13.4 2.2 2 23 868 890 867 890 0.97
11 14 0.0013 0.1 13.3 1.4 1 23 978 1001 978 1001 0.92
12 14 0.15 11 6.9 1.5 1 21 1053 1073 1053 1074 0.95
13 14 0.56 42 5.1 0.1 2 23 1117 1141 1116 1141 0.80
14 14 8.2 6.2e+02 1.4 0.8 1 10 1159 1168 1159 1183 0.68

Sequence Information

Coding Sequence
ATGGAAGGTATGGATCTGTGGACGTCAATGTTTTCAGCCGATTTCGAAGAAAGTGATGGTGAGGTGGAGAGCCATAATAATGGCAGTAACGCGCTCGCAGACGAGTTTATGGGtgaagaggaggaggacgaACAGGAGGCTGAAAAGGATGAGAGCTCGACCGACGGCAGAGGCAGCAAACGAAAAGGACACGAACCTGATGACGATGccatatttgattttgaactAGAGCCTATTGTTAGCATTGCGGAACCAGAACTGGAACCGTTGCCTAGACCAACGGGGGCCCCACTGCAGCCACCAATGCCAACGGGTTCACCCGTCCGACCCCAGCACCGTCAGTCGTTGCCAGCCTCGTTTGGCTCCCAGCAGATGGTGGGTCGTGGCGGTGCAGGTGCACTATCCACTCGGCCAACGACCTCACAAATCAATGCCACCGATGAGAACGGTCTGCCCATCAATTATGAACTGGGTGTTACCTATATATGCCCCGCCTGCGGCGCAGAGTATCGGCAGCAGGATATGTGGAAGCGTCACATGAACCAGATGCATCAGTACAATACTCGACGTGGTCTCAATTTTGTGGCCATTGACAAGCTGTATCATCGGTGCCTTGAGTGCAACAAGCGGATCGCGATGCACAGCCGGGAGAATTTGCTTAAGCACAAGTTCACCCATTTGCCATTTCGATGCACCAAGTGTCACATATGCAAACGCGAGTACAAATACAGGCAGGACCTGATGGTACATTTGCGTATGGTGCACTGTGATGAAGTGGTGGCCATGATGCGTGATGGTAAATTAAGTGCCGGCCGCAAGACGCGCGTTCGCGAGCCGCGCATCGACCAGCACCGCGAACAGTACAGACAGGTTCAGGACGATGATGGCATACAGGTCAAGAATGAGCTGATGGAAGCGGAGGGCAGTGTGGACCCAGCAGAAGAGTCCAATCAAGACTTGGATGATGAACACAGTCACAGTTCCAATCAAGCAGTAAAAAAGAAACGTAACACTTCTGTGGCAGCCAATGGGAGTGTGAATGGCAGTGGTGCAGCGGATATTTGCGAGgactatatacactatatgTGTCCTGACTGTGGCACCGATTGTGATACGCACGCCCAGTGGAGTCAGCATATTGAATTTGTGCACGATTACGTCAGTCGAAGGGGCCTGAACTTTCGTTGCGTGGATATGCAAATGCAGTGCCTCGAGTGCAAGCAGTTTGTCATTCCGAACACCATTAAGACGCTGCGCGCACACAAATTTAGCCACTTGCCACAACCGGAGTGGATGCGCTGCAAGCTGTGCTATCAGGGATACACGGAGCATCACGAACTAGTTACGCATCTTCTTAAACAGCATAATTTGGAAACCTTAATGCCTGAGAAgccggaggaggaggagcagcagcagcagccgcagcctccTTTGACTATATCCAGTGTGGGTGATGAGTGTGAGGATAATCCTGGCATTGTGTGCGATGATGAAACTTCATTGCATTGGGACGATGTGCCGCGTCGTGGTGGTCGTATTGGTAGCGATGATATGTACGAGCCGCATATTGATTATCTATGTCCGCAGTGCGGCAGGGAGTTCATAGAGAAGAAACATTGGCGCACACATGTTGTCCAAGTGCACGGCATGAATGATCTGACCAAGTTGAATTTTGAGGTGATCAACGATCGCCAGTTGAAGTGCACGGAATGCGATAAGATAATAACGAATGCCTATGGCATACAGAATGCCCAGCAACATAGGATCACACATTTGCCCTACAAAGCGTACGCGAGATGTCGCAAATGCCATAAATCCTATACGGATCGCAAAGGTCTTGTCAAACACTTGGCCACATACCATCGCGTGGGCTACGAGCCGCGCAAAACGGTTGGAACAGGTGCTGCTACGTTGACGCCAACCAAATTACAAACGCCACGCAAGCAAATTGTCACCGTGGCCAATGAGACCTATGAGATTATCTATTTGGATGAGGATCAATCGCCGCccagtaataataatataaatgaagaGAATGATTTTGGCGAGCAAATGCAAGCAGACGATGATGATTATGCCGTGGGCAGCACCAGTAGCATAATGGGACGCCAGCCGCAAGCACCCACTGCTGCTGCACCCAATCCTAATCCTAATCGTTATAAATGCGTAGATTGCGGTTCGCTGTTTGCCACACAGATGGCACTCAAGACGCACATCAGCGAGGAACATGATTTTATGGACACGCAATACAGTGCCAAAAAGTTTGACAATGCGGAGCCCACGGAGGAGGCAGCTGCAGTGCCTGTTGCCGTTTCCACCACTGCAGGTAGCGCGTCTGTAAAGAACACCTCAGGCGCTTCCACCATAgagcaaaattatatattcctGTGCCCGTCGTGCGGCGAGGCCTACAAGACGCAGTTCGAGTGGCGGCGCCACATCAATGAGGAGCACAATTTCGACAAACGACAGTATTTAAATATGCGCCAGCTGGACAAATATCGCTATCAATGCACGCATTGCAAGGATATTGTATGCAATTCAAAGCTGAAAGGCCTGCAGGATCATCATTTTCGTCATTTGCCTTACCGGCTATATCTGAAGTGCCTGGTGTGCGGCACCTGCTACAATCACAAGCCAAATATAGCAGCGCATTTGCGCACGCGACACAACATCTATGAGCGCGAGTCCTCATCGTGGCGTGACCAGCACCAAAAGACATCGAATGGCCACGAGCAGCTTAAGTATAAGGATAAGGATAGGGATACacaagctgctgttgccaccgGCACTACTTCTGCTTCACCGACACCCGGCAGTAGTCGCACACTCAAGCCACAGCCGGGCGTGTTGCCCACGCGACCCGCTGGACTTAACACATTGGAGGATAGTATATCGTACCACAATGCCGTAGATCTGGACTTTATTACCTATTATTGTCCCAAGTGCAATAAGAACTTTGACTCGCACGCCTTTTGGCGCAAACACATCGTGGAGGTACACAACTACAATAGTCGGCAAGGCCTGAACTTTCGCCAGATTGACAACCATCACTATCTGTGCCTGGAGTGCTATAAGCGTGTGACTGTGACGCACACAAAGGGCGCTATCGGGCAGCTACAGTCGCACAAGTTCCGGCATTTGCCGTATCGCTCCTTCAAATGCTTGACTTGCAGCGGGGAGTTTGTGCGCAAGCAAATGTTCTTCAAGCATTTGAACCGCGACACCAATCGTTGCGACAACAAGCCATTAAGTGGCCAGGAGATTGATGAGGATACAGCGGATCAACCAGACAGGCCAGCTGCCATGGTCGCCAAGGAGACACTCGATGTTGCGGCGTATCGTTTGATGTGTCCACAGTGCGGTGATGGGTTTACCACCAGCAGCAAAGCTTTGTGGCGAGAGCACATTAACATCCAGCATAGTCTGGGTAAGCGGGAGATGCTGCACATGCGCAAACTAGGCGACGAACTTTATCGCTGCACAGATTGTGAAGAGCAGCTGCAAACGAAGCACCTGCGAGTGCTGCAGCAACATCGCTTCCAGCACTTGCCCTATGCCGCATATATACGCTGCCAGCTATGTGAACAGCAGTCGGCGGATGGAGTGGGCCATGGTGTGGCGTCTGCCGGTTTACATAGTATGCGCGAACTGCAACAGCACATACGCAACGAGCATCCGGATGTGGTTGATCAGGACGAGCAAATGCAAGCATTACTCGAAGAGGAGGAGGATAGTCAGCAGCCGGCGGTTAGCGGTGAGGCAACAGACAGTGGACTATAtatgccgctgccgccgcatTTGCTGGACGATGATGTGGAGGACATGGAGTTCGAGGAACAGTATCTGCTAGGTTAA
Protein Sequence
MEGMDLWTSMFSADFEESDGEVESHNNGSNALADEFMGEEEEDEQEAEKDESSTDGRGSKRKGHEPDDDAIFDFELEPIVSIAEPELEPLPRPTGAPLQPPMPTGSPVRPQHRQSLPASFGSQQMVGRGGAGALSTRPTTSQINATDENGLPINYELGVTYICPACGAEYRQQDMWKRHMNQMHQYNTRRGLNFVAIDKLYHRCLECNKRIAMHSRENLLKHKFTHLPFRCTKCHICKREYKYRQDLMVHLRMVHCDEVVAMMRDGKLSAGRKTRVREPRIDQHREQYRQVQDDDGIQVKNELMEAEGSVDPAEESNQDLDDEHSHSSNQAVKKKRNTSVAANGSVNGSGAADICEDYIHYMCPDCGTDCDTHAQWSQHIEFVHDYVSRRGLNFRCVDMQMQCLECKQFVIPNTIKTLRAHKFSHLPQPEWMRCKLCYQGYTEHHELVTHLLKQHNLETLMPEKPEEEEQQQQPQPPLTISSVGDECEDNPGIVCDDETSLHWDDVPRRGGRIGSDDMYEPHIDYLCPQCGREFIEKKHWRTHVVQVHGMNDLTKLNFEVINDRQLKCTECDKIITNAYGIQNAQQHRITHLPYKAYARCRKCHKSYTDRKGLVKHLATYHRVGYEPRKTVGTGAATLTPTKLQTPRKQIVTVANETYEIIYLDEDQSPPSNNNINEENDFGEQMQADDDDYAVGSTSSIMGRQPQAPTAAAPNPNPNRYKCVDCGSLFATQMALKTHISEEHDFMDTQYSAKKFDNAEPTEEAAAVPVAVSTTAGSASVKNTSGASTIEQNYIFLCPSCGEAYKTQFEWRRHINEEHNFDKRQYLNMRQLDKYRYQCTHCKDIVCNSKLKGLQDHHFRHLPYRLYLKCLVCGTCYNHKPNIAAHLRTRHNIYERESSSWRDQHQKTSNGHEQLKYKDKDRDTQAAVATGTTSASPTPGSSRTLKPQPGVLPTRPAGLNTLEDSISYHNAVDLDFITYYCPKCNKNFDSHAFWRKHIVEVHNYNSRQGLNFRQIDNHHYLCLECYKRVTVTHTKGAIGQLQSHKFRHLPYRSFKCLTCSGEFVRKQMFFKHLNRDTNRCDNKPLSGQEIDEDTADQPDRPAAMVAKETLDVAAYRLMCPQCGDGFTTSSKALWREHINIQHSLGKREMLHMRKLGDELYRCTDCEEQLQTKHLRVLQQHRFQHLPYAAYIRCQLCEQQSADGVGHGVASAGLHSMRELQQHIRNEHPDVVDQDEQMQALLEEEEDSQQPAVSGEATDSGLYMPLPPHLLDDDVEDMEFEEQYLLG