Basic Information

Gene Symbol
-
Assembly
GCA_003086615.1
Location
LUVX01024619.1:11878-16860[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.00035 0.03 14.8 0.1 1 23 160 183 160 183 0.96
2 15 0.0012 0.11 13.1 2.9 2 23 232 254 228 254 0.89
3 15 0.011 0.91 10.2 0.9 1 23 360 383 360 383 0.93
4 15 0.18 15 6.3 4.8 2 23 432 454 431 455 0.95
5 15 0.0028 0.24 12.0 0.5 1 23 516 539 516 539 0.88
6 15 1.7 1.5e+02 3.2 0.1 2 14 558 570 557 582 0.85
7 15 0.00059 0.05 14.1 3.3 2 23 590 612 590 612 0.96
8 15 0.00067 0.058 13.9 0.1 1 23 718 741 718 741 0.95
9 15 7.1e-05 0.0061 17.0 0.3 1 23 794 817 794 817 0.93
10 15 0.00099 0.085 13.4 2.2 2 23 867 889 866 889 0.97
11 15 0.0016 0.14 12.8 2.0 1 23 974 997 974 997 0.92
12 15 0.12 10 6.9 1.5 1 21 1049 1069 1049 1070 0.95
13 15 0.44 37 5.1 0.1 2 23 1113 1137 1112 1137 0.80
14 15 6.1 5.2e+02 1.5 0.4 1 9 1155 1163 1155 1179 0.68
15 15 5.7 4.9e+02 1.6 0.4 15 23 1214 1223 1211 1223 0.89

Sequence Information

Coding Sequence
ATGGAAGGTATGGACCTGTGGACGTCCATGTTTTCAGCAGATTTCGAAGAGGGCGACGGTGAGTTAGAGAGTCACAATAACGGTAACAGCGCGCTGGCAGACGAGTTTATGGGcgaagaggaggaggacgaACAGGAGGCTGAAGAAGATGAGGGGACGGGTGAAGACAGAGACAGCAAGCGAAAAGGACACGAGCCCGATGACGATgccatatttgattttgaactAGAGCCAATTGTTAGCATTGCGGAACCAGAACCGGAATCTGTGCCAAGACCAACGGTCCCCCTGGCGCCACCAATGCCAACGGGTCCAGCCATCCGACCACAGCACCGCCAATCGTTGCCAGCATCGTTTGGCTCCCAGTTGATAGTGGGTCGCGGCGGTGCAGGCGTTCCACCCACACGGCCAACGACCTCACAAATCAATGCAACCGATGAGAACGGTGTGCCCATTAATTATGAGCTGGGCGTCATCTATATATGCCCCGCCTGCGGCGCCGAGTATCGGCAGCAGGACATGTGGAAGCGTCACATGAACCAGATGCATCAGTATAATACGCGACGGGGTCTCAATTTCGTGGCCATTGATAAGCTATATCATCGGTGCTTGGAATGCAATAAGCGCATCGCAATGCACAGTCGGGAGAATCTTCTGAAGCACAAGTTTACCCATTTGCCATACCGCTGCACCAAGTGCTACATCTGTAAGCGCGAGTACAAGTACAGGCAGGACCTGATGGTGCATTTGCGCATGGTGCACTGTGACGAAGTGGTGGCTATGATGCGCGGCGGTGATGCCAGTGCCGGACGCAAGACACGTGTGCGCGAGCCGCGCATTGAGCAGCATCACGGGCCCTACGGGCCGGAacatgacgatgacgacggcATAGAGGTCAAGAATGAGCTGATGTTGGAGGCGGAGGGCGGCGCGCAGGCAGCTGATGAGTCCAACTTTGGTCTGGATGATGAGCACAGTCGCAGTTCCAGTCAAGCGGCTAGGAAAAAGCGCGGCACTGCTGTGGCTGGCAATGGAAGTGGAAACGGTGCTGCAGACATATGCGAAGACTATATACACTATATGTGTCCCGACTGCGGCACCGATTGCGATACGCACGCCCAATGGAGTCAACATATTGAATTTGTGCATGACTACGTCAGTCGGCGAGGGCTGAACTTTCGCTGCGTGGACATGCAGATGCAGTGCCTCGAGTGCAAGCAGTTTGTCATTCCGAACACGATAAAGACGCTGCGTGCGCACAAGTTTAGCCATTTACCTCAGCCGGAGTGGATGCGCTGCAAGCTGTGCTATCAGGGCTTTACGGAGCATCATGAGCTGCTCGCGCATCTACTAAAGCAGCATCATTTGGAAACCCTAATGCCTGAAAAGGAGGAGGAGCAATCCTTGGCCACAGCCGGTGCGGGTGATGAGGGCGAGAATACTCAAGGCATTGGCGGCGATGAGGAATCTCAGTTGCAATGGGACGATGTGCCGCGTCGTGGCGGTCGCATTGGCAGCGACGATATGTACGAGCCGCATATTGATTATCTGTGTCCGCAGTGCGGCAGGGAGTTTATAGAGAAGAAGCACTGGCGCACACATGTTGTCCAGGTGCACGGCATGAACGATCTGGCCAAGTTGAACTTCGAGGTGATCAACGATCGCCAGCTGAAGTGCACCGAGTGCGATAAGATCATAACGAATGCCTATGGCATACAGAATGCCCAGCAGCACAGGATAACTCATTTGCCCTACAAGGCGTACGCGAGATGCCGTAAATGCCATAAATCCTACACGGATCGCAAGGGTCTGGTCAAGCATTTGGCCACATACCATCGCGTTGGCTATGAACCACGCAAAGCGGGCGCCGTACTAGGCACTGGCACACCGTTGGTCATGGCCTTAAACCCAGCCAAATCACAGACGCCACGCAAACAAATTGTCACTGTGGCCAACGAAACCTATGAGATTATATATTTGGATGAGGAGCAATCGCCGccaagtaataataatattaatgaggAGAATGACTTTGGAGAGCAAATGCAGgcggatgatgatgattatgccATCATAGGCAGCACCAGCGGCAGCATGGGACGCCAGCTGCCACCAATTGCCGCTGCTTCCGATGCACCAAATCCCAATCGCTACAAATGCGTGGACTGCGGCTCACTGTTTGCTACGCAGGCGGCGCTGAAGACACACATCAGCGAGGAGCATGATTTCATGGATACACAGTATAGCGCCAAAAAGTTTGATAATGCGGAGCCCTCAGAggaggcagctgcagctgcgcctgTTGCCGTGACGACAGCAGCCACTGCTATGCCCGTCAAAAACAGCGCCGGAGCCTCTACCATAGAACAGAATTATATATTCCTGTGCCCGTCATGCGGCAAGGCTTACAAGACGCAGTTCGAGTGGCGACGTCACATCAACGAGGAGCACAATTTTGACAAGCGACAATACTTAAATATGCGCCAGCTGGATAAGTATCGCTATCAGTGCACCCTGTGCAAGGACATTGTGTGCAATTCGAAGCTGAAAGGCTTGCAGGATCATCATTTTCGTCATTTGCCTTATCGCCTGTATCTGAAGTGTCTGGTGTGCGGCACCTGCTACAATCACAAGCCCAACATTGCGGCACATCTGCGCACACGACACAACATCTACGAACGCGAGTCCTCGTGGCGTGAGCACCAACCCAAGACCCAGAATGGCTACGAACAGCTCAAGTATAAGGATAAGGATAGGGACATGCAGACCATGGCAGGCACCAGCTCAGGATCACCAACGCCGGGAAGCAGTCGCACGCTCAAACCACAACCGGGCGTGCTGCCCACGCGACCCGCTGGCCTCAATACGCTGGAGGACAGCATCTCGTATCATAATGCCGTGGATCTGGACTTTATTACCTACTATTGCCCCAAGTGCAACAAGAACTTTGATTCGCACGCCTTCTGGCGCAAACACATTGTCGAGCAGCACAACTATAACAGTCGGCAGGGCTTGAACTTTCGCCAGATTGACAACCATCACTATTTGTGCCTGGAGTGCTATAAGCGTGTGACTGTGACTCATACCAAGGGGGCAATTGGGCAGCTGCAGTCGCACAAGTTCCGGCATTTGCCGTATCGCTCCTTTAAGTGCTTGACCTGCAGCGGCGAGTTTGTGCGCAAGCAAATGTTCTTCAAGCATTTGAATCGGGACACCAATCGCTGTGACAACAAGCCAATGAGTTGCCAGGATAATGATGAGGATACAGCAGAACAGCCGGATAGGCCAGTTGCCATGCCCGTTAAGGCGGCACTTGATGGCGCCACGTATCGTTTGATGTGCCCGCAGTGCGGTGATGGCTtcaccaccagcagcaaagCACTCTGGCGGgagcatataaatatctatcaTGGTCTGGGCAAGCGCGATCTGCTGCATATGCGTAAACTGGGCGAGGAACTGTATCGCTGCACAGACTgtgaggagcagctgcagaccAAACAGTTGCgcgtgctgcagcagcatcgctTCCAGCATTTGCCCTATGCCGCCTACATACGCTGCCAGCTGtgcgaacagcagcaaccgccGGATGGACTGGGTCATGGTGCAGCCGCTGCCGGATTACATAGTATGcgcgagctgcagcagcacatgcGTAGTGAGCACCCCAATGTGGCGGAGCATGATGACCAAATGCAAGCTCTGCTGGAGGAGGAAGAGGTGGAAGATGTTCAGCAGCCGGCGGCTAACAGTGAGTCGGACAATGGTCCATATATGCCATTACCGCCCCATTTGCTGGACGATGATGTCGAGGACATGGAGTTCGAGGAGCAGTATCTGCTGGGCTAA
Protein Sequence
MEGMDLWTSMFSADFEEGDGELESHNNGNSALADEFMGEEEEDEQEAEEDEGTGEDRDSKRKGHEPDDDAIFDFELEPIVSIAEPEPESVPRPTVPLAPPMPTGPAIRPQHRQSLPASFGSQLIVGRGGAGVPPTRPTTSQINATDENGVPINYELGVIYICPACGAEYRQQDMWKRHMNQMHQYNTRRGLNFVAIDKLYHRCLECNKRIAMHSRENLLKHKFTHLPYRCTKCYICKREYKYRQDLMVHLRMVHCDEVVAMMRGGDASAGRKTRVREPRIEQHHGPYGPEHDDDDGIEVKNELMLEAEGGAQAADESNFGLDDEHSRSSSQAARKKRGTAVAGNGSGNGAADICEDYIHYMCPDCGTDCDTHAQWSQHIEFVHDYVSRRGLNFRCVDMQMQCLECKQFVIPNTIKTLRAHKFSHLPQPEWMRCKLCYQGFTEHHELLAHLLKQHHLETLMPEKEEEQSLATAGAGDEGENTQGIGGDEESQLQWDDVPRRGGRIGSDDMYEPHIDYLCPQCGREFIEKKHWRTHVVQVHGMNDLAKLNFEVINDRQLKCTECDKIITNAYGIQNAQQHRITHLPYKAYARCRKCHKSYTDRKGLVKHLATYHRVGYEPRKAGAVLGTGTPLVMALNPAKSQTPRKQIVTVANETYEIIYLDEEQSPPSNNNINEENDFGEQMQADDDDYAIIGSTSGSMGRQLPPIAAASDAPNPNRYKCVDCGSLFATQAALKTHISEEHDFMDTQYSAKKFDNAEPSEEAAAAAPVAVTTAATAMPVKNSAGASTIEQNYIFLCPSCGKAYKTQFEWRRHINEEHNFDKRQYLNMRQLDKYRYQCTLCKDIVCNSKLKGLQDHHFRHLPYRLYLKCLVCGTCYNHKPNIAAHLRTRHNIYERESSWREHQPKTQNGYEQLKYKDKDRDMQTMAGTSSGSPTPGSSRTLKPQPGVLPTRPAGLNTLEDSISYHNAVDLDFITYYCPKCNKNFDSHAFWRKHIVEQHNYNSRQGLNFRQIDNHHYLCLECYKRVTVTHTKGAIGQLQSHKFRHLPYRSFKCLTCSGEFVRKQMFFKHLNRDTNRCDNKPMSCQDNDEDTAEQPDRPVAMPVKAALDGATYRLMCPQCGDGFTTSSKALWREHINIYHGLGKRDLLHMRKLGEELYRCTDCEEQLQTKQLRVLQQHRFQHLPYAAYIRCQLCEQQQPPDGLGHGAAAAGLHSMRELQQHMRSEHPNVAEHDDQMQALLEEEEVEDVQQPAANSESDNGPYMPLPPHLLDDDVEDMEFEEQYLLG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2