Basic Information

Insect: Drosophila americana
Gene Symbol: -
Assembly: GCA_018152915.1
Location: JAECXQ010000444.1:224516-228427[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 0.0004 0.024 14.8 0.1 1 23 160 183 160 183 0.96

2 15 0.0014 0.082 13.1 2.9 2 23 232 254 228 254 0.89

3 15 0.012 0.7 10.2 0.8 1 23 360 383 360 383 0.93

4 15 0.53 31 5.0 3.6 2 23 432 454 431 454 0.96

5 15 0.0032 0.19 12.0 0.5 1 23 516 539 516 539 0.88

6 15 2 1.1e+02 3.2 0.1 2 14 558 570 557 582 0.85

7 15 0.00068 0.04 14.1 3.3 2 23 590 612 590 612 0.96

8 15 0.00077 0.045 13.9 0.1 1 23 718 741 718 741 0.95

9 15 8.2e-05 0.0048 17.0 0.3 1 23 794 817 794 817 0.93

10 15 0.0011 0.066 13.4 2.2 2 23 867 889 866 889 0.97

11 15 0.0018 0.11 12.8 2.0 1 23 974 997 974 997 0.92

12 15 0.13 7.8 6.9 1.5 1 21 1049 1069 1049 1070 0.95

13 15 0.5 29 5.1 0.1 2 23 1113 1137 1112 1137 0.80

14 15 2.8 1.6e+02 2.7 0.3 1 9 1155 1163 1155 1179 0.75

15 15 3.6 2.1e+02 2.4 0.8 15 23 1214 1223 1211 1223 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	0.0004	0.024	14.8	0.1	1	23	160	183	160	183	0.96
2	15	0.0014	0.082	13.1	2.9	2	23	232	254	228	254	0.89
3	15	0.012	0.7	10.2	0.8	1	23	360	383	360	383	0.93
4	15	0.53	31	5.0	3.6	2	23	432	454	431	454	0.96
5	15	0.0032	0.19	12.0	0.5	1	23	516	539	516	539	0.88
6	15	2	1.1e+02	3.2	0.1	2	14	558	570	557	582	0.85
7	15	0.00068	0.04	14.1	3.3	2	23	590	612	590	612	0.96
8	15	0.00077	0.045	13.9	0.1	1	23	718	741	718	741	0.95
9	15	8.2e-05	0.0048	17.0	0.3	1	23	794	817	794	817	0.93
10	15	0.0011	0.066	13.4	2.2	2	23	867	889	866	889	0.97
11	15	0.0018	0.11	12.8	2.0	1	23	974	997	974	997	0.92
12	15	0.13	7.8	6.9	1.5	1	21	1049	1069	1049	1070	0.95
13	15	0.5	29	5.1	0.1	2	23	1113	1137	1112	1137	0.80
14	15	2.8	1.6e+02	2.7	0.3	1	9	1155	1163	1155	1179	0.75
15	15	3.6	2.1e+02	2.4	0.8	15	23	1214	1223	1211	1223	0.89

Sequence Information

Coding Sequence: ATGGAAGGTATGGACCTGTGGACGTCCATGTTTTCAGCCGATTTCGACGAAGGCGACGGTCGGGTAGAGAGTCACGATAACGGTAACAGCGCGCTGACAGACGAGTTTATGGGCGAAGAGGAGGAGGATGAACAAGAGGCTGAAGAGGATGAGGGGACGGGTGAAGGCAGAGACAGCAAGCGAAAAGGACACGAGCCCGATGACGATGCTATATTTGATTTTGAACTAGAGCCAATTGTTAGCATCGCGGAACCAGAACCGGAACCTGTGCCAAGACCAACGGTCCCCCTTGCGCCACCAATGCCAGCGGGTCCAGCCATCCGACCACAGCACCGCCAATCGTTGCCAGCATCGTTTGGCTCCCAGTTGATAGTGGGACGCGGGGGTGCAGGCGCTCCACCCACACGGCCAACAACCTCACAAATCAATGCAACCGACGAGAACGGTGTGCCCATTAATTATGAGCTGGGCGTCATCTATATATGCCCCGCCTGTGGCGCTGAGTATCGGCAGCAGGACATGTGGAAGCGTCACATGAACCAGATGCATCAGTATAATACGCGACGGGGTCTCAATTTCGTGGCCATTGATAAGCTGTATCATCGGTGCTTGGAATGTAATAAGCGCATCGCAATGCACAGTCGGGAGAATCTTCTGAAGCACAAGTTCACCCATTTGCCATACCGTTGCACCAAGTGCTACATTTGTAAGCGCGAGTACAAATACAGGCAGGACCTGATGGTGCATTTACGCATGGTGCACTGTGACGAAGTGGTGGCCATGATGCGCGGCGGTGATGCCAGTGCCGGACGCAAGACACGTGTGCGGGAGCCGCGCATTGAGCAGCATCACGGACTCTACGGGCCGGAACATGACGATGACGACGGCATAGAGGTCAAGAATGAGCTGATGTTCGAGGGGGAGGGCGGCGTGCTGACAGCTGATGAGTCCAACATTGGACCGGATGATGAGCACAGTCGCAGCTCCAGTCAAACGGCTAAGAAGAAGCGCGGCACTGCTGTGGCTGGCAATGGGAGTGGAAGCGGTGCAGCAGACATATGCGAAGATTATATACATTATATGTGTCCTGACTGCGGCACCGATTGCGAAACGCACGCCCAATGGAGTCAACATATTGAATTTGTGCATGACTATGTCAGTCGGCGAGGGTTGAACTTTTGCTGCGTGGACATGCAGATGCAGTGCCTCGAGTGCAAGCAGTTTGTCATTCCGAATACGATAAAGACGCTGCGGGCGCACAAGTTTAGCCATTTACCTCAGCCGGAGTGGATGCGCTGCAAGCTGTGCTATCAGGGCTATACGGAGCATCATGAGCTGCTCACGCATCTACTGAAGCAGCATAATTTGGAAACCCTAATTCCTGAAAAGGAGGAGGAGCAGTCCTTGGCCAGAGCCGGTGCGGGTGATGAGGGCGAGGATACTCCAGGCATTGGCGGCGATGAGGAATCCCAGTTGCAATGGGACGATGTGCCGCGTCGTGGCGGTCGCATTGGCAGCGATGATATGTACGAGCCACATATTGATTATCTGTGCCCGCAGTGCGGCAGGGAGTTTATAGAGAAGAAGCACTGGCGTACACATGTTGTGCAGGTGCACGGCATGAACGATCTGGCCAAGTTGAACTTCGAGGTGATCAACGATCGCCAGCTGAAATGCACAGAGTGCGATAAGATCATAACGAATGCCTATGGCATACAGAATGCCCAGCAGCACAGGATAACGCATTTGCCCTACAAAGCGTACGCAAGATGTCGTAAATGCCATAAGTCCTACACTGATCGCAAGGGTCTGGTCAAACATTTGGCCACATACCATCGCGTCGGCTATGAACCACGCAAAGCGGGCGCCGTACTAGGCACAGGCACACCATCGATCATGGCCTTAAACCCAGCCAAATCACAGACGCCGCGCAAACAAATTGTTACTGTAGCTAACGAAACCTATGAGATTATATATTTGGATGAGGAGCAATCGTCGCCAAGTAATAATAATATTAATGAGGAGAATGACTTTGGAGAGCAAATGCAGGCGGATGATGATGATTATGCCATCATAGGCAGCACCAGCGGCAGCATGGGACGCCAGCTGCTACCAATTGCTGCTGCTTCCGAGATACCGAATCCCAATCGCTACAAATGCGTGGACTGTGGCTCACTGTTTGCTACGCAGGCGGCGCTGAAGACGCACATCAGCGAGGAGCATGATTTCATGGACACACAGTATAGCGCCAAAAAGTTTGATAATGCGGAGCCCTTAGAGGAGGCAGCTCCAGCTGCGCCTGTTGCCGTGACGACAGCAGCCACTGCTATGCCCGTCAAGAACAGCGCCGGCGCCTCTACCATAGAACAGAATTATATATTCCTGTGCCCGTCATGCGGCAAGGCCTACAAGACGCAGTTCGAGTGGCGACGTCACATCAACGAGGAGCACAATTTTGACAAGCGACAATACTTAAATATGCGCCAGCTGGACAAGTATCGCTATCAGTGCACTCTGTGCAAGGACATTGTGTGCAATTCGAAGCTGAAAGGCCTGCAGGATCATCATTTTCGTCATTTGCCTTATCGCCTATATCTGAAGTGTCTGGTGTGCGGCACCTGCTACAATCATAAGCCCAACATTGCGGCACATCTTCGCACACGACACAACATTTACGAACGCGAGTCCTTGTGGCGTGAGCAACCACCCAAGACCCAGAATGGCTACGAACAGCTCAAGTACAAGGATAAGGATAGGGACATGCAGACCACGGCAGGCACCAGCTCAGGATCACCAACGCCAGGCAGCAGTCGCACGCTCAAACCGCAACCGGGCGTGTTACCCACGCGTCCCGCTGGCCTCAATACGCTGGAGGACAGCATCTCGTATCATAATGCCGTGGATCTGGACTTTATTACCTACTATTGCCCCAAGTGCAACAAGAACTTTGATTCGCACGCCTTCTGGCGCAAACACATTGTCGAGCAGCACAACTATAACAGTCGGCAGGGTCTGAACTTTCGCCAGATTGACAACCATCACTATTTGTGTCTGGAGTGCTATAAGCGTGTGACTGTGACTCACACCAAGGGGGCAATTGGGCAGCTGCAGTCGCACAAGTTTCGGCATTTGCCGTATCGCTCCTTTAAGTGCCTGACCTGCAGCGGCGAGTTTGTGCGCAAACAAATGTTCTTCAAGCATTTGAATCGGGACACCAATCGATGTGACAACAAGTCAATGAGTTGCCAAGATAATGATGAGGATACAGGGGAGCAGCCGGACAGGCCAGTTGCCATGACTGTTAAGGCGGCACTTGATGGCGCCACGTATCGTTTGATGTGCCCGCAGTGTGGTGATGGCTTCACCACCAGCAGCAAAGCGCTCTGGCGAGAGCACATAAATATTTATCATGGTCTGGGCAAGCGCGATCTGCTGCATATGCGTAAACTGGGCGAGGAACTGTATCGCTGCACAGACTGTGATGAGCAGCTGCAGACCAAACAGATGCGCGTGCTGCAGCAGCATCGCTTCCAGCATTTGCCCTATGCCGCCTACATACGCTGCCAACTGTGCGAACAGCAACAACCGCCGGATGGTCTGGTGCATGGTGCAGCCGCTGCCGGATTACATAGTATGCGCGAGCTGCAGCAGCACATGCGAACCCAGCACCCCAATGTGGCGGAGCATGATGACCAAATGCAAGCGCTGCTGGAGGAGGAGGAGGTGGAAGAAGTTCAGCAGGCGGTGGATAACAGTGAAACGTCAAGCAATGGTCCATATATGCCATTACCGCCGCATTTGCTGGACGATGACGTCGAGGACATGGAGTTCGAGGAGCAGTATCTGCTGGGCTAA
Protein Sequence: MEGMDLWTSMFSADFDEGDGRVESHDNGNSALTDEFMGEEEEDEQEAEEDEGTGEGRDSKRKGHEPDDDAIFDFELEPIVSIAEPEPEPVPRPTVPLAPPMPAGPAIRPQHRQSLPASFGSQLIVGRGGAGAPPTRPTTSQINATDENGVPINYELGVIYICPACGAEYRQQDMWKRHMNQMHQYNTRRGLNFVAIDKLYHRCLECNKRIAMHSRENLLKHKFTHLPYRCTKCYICKREYKYRQDLMVHLRMVHCDEVVAMMRGGDASAGRKTRVREPRIEQHHGLYGPEHDDDDGIEVKNELMFEGEGGVLTADESNIGPDDEHSRSSSQTAKKKRGTAVAGNGSGSGAADICEDYIHYMCPDCGTDCETHAQWSQHIEFVHDYVSRRGLNFCCVDMQMQCLECKQFVIPNTIKTLRAHKFSHLPQPEWMRCKLCYQGYTEHHELLTHLLKQHNLETLIPEKEEEQSLARAGAGDEGEDTPGIGGDEESQLQWDDVPRRGGRIGSDDMYEPHIDYLCPQCGREFIEKKHWRTHVVQVHGMNDLAKLNFEVINDRQLKCTECDKIITNAYGIQNAQQHRITHLPYKAYARCRKCHKSYTDRKGLVKHLATYHRVGYEPRKAGAVLGTGTPSIMALNPAKSQTPRKQIVTVANETYEIIYLDEEQSSPSNNNINEENDFGEQMQADDDDYAIIGSTSGSMGRQLLPIAAASEIPNPNRYKCVDCGSLFATQAALKTHISEEHDFMDTQYSAKKFDNAEPLEEAAPAAPVAVTTAATAMPVKNSAGASTIEQNYIFLCPSCGKAYKTQFEWRRHINEEHNFDKRQYLNMRQLDKYRYQCTLCKDIVCNSKLKGLQDHHFRHLPYRLYLKCLVCGTCYNHKPNIAAHLRTRHNIYERESLWREQPPKTQNGYEQLKYKDKDRDMQTTAGTSSGSPTPGSSRTLKPQPGVLPTRPAGLNTLEDSISYHNAVDLDFITYYCPKCNKNFDSHAFWRKHIVEQHNYNSRQGLNFRQIDNHHYLCLECYKRVTVTHTKGAIGQLQSHKFRHLPYRSFKCLTCSGEFVRKQMFFKHLNRDTNRCDNKSMSCQDNDEDTGEQPDRPVAMTVKAALDGATYRLMCPQCGDGFTTSSKALWREHINIYHGLGKRDLLHMRKLGEELYRCTDCDEQLQTKQMRVLQQHRFQHLPYAAYIRCQLCEQQQPPDGLVHGAAAAGLHSMRELQQHMRTQHPNVAEHDDQMQALLEEEEVEEVQQAVDNSETSSNGPYMPLPPHLLDDDVEDMEFEEQYLLG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00532646;
90% Identity: iTF_00551114;
80% Identity: -