Dmac014317.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila maculinotata
Gene Symbol
ush
Assembly
GCA_035045305.1
Location
JAWNPD010000678.1:243362-249069[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0072 0.49 11.0 0.0 1 20 204 223 204 225 0.90
2 9 0.00031 0.021 15.3 0.8 1 23 282 304 282 304 0.98
3 9 0.055 3.7 8.3 1.0 2 21 352 371 352 372 0.92
4 9 0.053 3.6 8.3 2.9 2 21 750 769 749 770 0.93
5 9 0.0099 0.67 10.6 0.0 3 21 816 834 814 835 0.91
6 9 0.0071 0.48 11.0 0.0 2 23 905 926 904 926 0.98
7 9 0.0042 0.28 11.8 1.3 1 23 932 954 932 954 0.99
8 9 0.0015 0.1 13.2 1.9 1 23 1021 1044 1021 1044 0.96
9 9 0.33 23 5.8 0.7 2 20 1155 1173 1154 1175 0.91

Sequence Information

Coding Sequence
ATGCGCTGGAATGCgccaaagcagcagcatcagcagcagcagcagcagaagaccCCAAAAAGAGCCGATGGGAGCAGAGAGAAGCCTTGGGGCAGCCTTCGCGCAGATGCTGTCGATTATTCCAAAGATTTGAGCGCACATGAGCTGAGCGAggagaagcaacaacagcagcagcagcagctcgagGATCAGCCCGAGGACGAGCAGTTAGATCAGCAGTTATCCAGCAACTCCTCCGAACAGCCCATAGAGACTGACATGGAGCAGGATCTCGATATGGAGACCCAGACTGCCCAGGAGGCCAGCGAGCAGAAGTTGGCCGACAACTCGACGACACCGCCGCGCAGTCCCACGCCCGAGCTGGTGCCCAAGCTGGAGCGAGCTGATACGCCGCCCTCCGTGACAGCCACGCCCAGTCCGCCGCCAACGCCCACGCCGCCCATGGTGCTACCCAAGCTGCGTCTCAATGCGCTGCTCGCCTCCGATCCGGCCCTGAAACCGGATGCCAAGGAGCTCAACCTGCACGAGTCACGACTGCTGGGACCACCATCCAAAccagagcagcaacagcagcagccggatgTGGAGCCACTGTTGAAACCTACACGCTTTATGTGCCTGCCCTGCGGCATAGCCTTCAGCTCGCCATCAACGCTGGAGGCGCACCAGGCCTACTACTGCTCCCATCGCAATAAGGATGCCGAGGAGGAGACGCCCTCTGGCGATAAAGCAACGCCGGGCAGTGGCGGCGCcaccaatgccaatgccaatagCAGCTCCAGCGGCTCCAGTGGTGGCACTGGCTCCGAGCCGCCCAACAAGGTGTCTCGCATGGGCAAACAATACGCCTGCACGCAGTGCTCCTACAGCGCCGACAAGAAGGTCTCCCTCAATCGACACATGCGCATGCATCAGACCTCCCCGGCCACACCCAGCCTCAACAGCCTCTCCAGCTTCACAGCCAACGgagttgttgccgctgcagctgccgcagctgctgctgctgctgctgccggtgcGCTCGAGGAGAGCTCTAGTCAACAAATCGATCGCTACTGCAGCGACTGTGATATCCGCTTCAACAACATCAAGACCTACCGCGCCCACAAGCAACACTACTGCAGCTCCCGCCGCAGCGATGGCCAGCTAACGCCCAAGCCAGAGGCGGGCGCCACTggagcggcagcggcagctgcagcgggcgctgctgttgctgccggcaAGCACAGTCCACAGACGCGCAACAAGACGCCAACGCCAGCAAtggttgctgccgctgctgctgccgccgccgccgctgctgcggcagctgccTCGCTGCAGGTGACTCCTCCGGAACCCTTTCTGGCACTGCCGACCAATCCGATTATCATAGTGCCCTGCTCGCTGATACGTGCCGCCAGACTGATACCGGGACCACTCACCACCTCCACTTCTGGCATTGTGAATCCGGAGTCCACGTGCTTCACGCTCGACAATGGCGCCCTTAAGCCGCTGGCGACGGCGCTCAACATCAATGCCCTGACGggcagtgccacgcccacacccacacccacaccaatGCCCAGCAGCAATCAGCTGGCGATGCCCGCTCTCGAGCCAGATCGTCCCACTGCGCCCAGCAATGTGAGCAGTCTGCTGGAGGCGGAGGCCAAGAGCAGCCCGCCGGAGTCCAGCAAGCGCAAGGAAGCCTCAGTCATGCGTGAGACGACGCCACTGGATTTATCACTGCGTCGTTCGCCAATTTccgcgctgctgcagcggcagcgactggtccgctctgctgctgcgctgctcgATGCCGAGGATGCTGCCGGCAAGGATCACGTGGAGAGCATCAGCGGCGGCAGCGTCACACCCGAGCAAATTGTGTGCGCTCCCTCGCTGCCCAGCAGCCCCTCGATGAGTCCGTCGCCCAAGCGACGTGCTTTAAGTCCACGCAGCTCCGGTGCCGGCAGCGCTTCATCGATGTCGCCACCGGCTACGCATCTGCTGGACAATCTGCCGCCCTTGCGTTCCATGCTGCCCGCGGAATTTTCGTTGTCCGAATCGCTCCTGGCAAAGACTAATCCTGAGCTGGCGCTCAAgttggcggcagcagctgcggcgGCAGTAGCAGGCAGCAGCTCAGCGGAGCTGGCCAAGCTAGGATTTGGAGTTGCCCCAGCTCAAAATCCTACCTCCGCTGCTGCTCAACCAGCCAACCCGCCGAATGCACCGCAGATCTATGTCAAGCAGGGCGTCTCCAAGTGCAAGGAGTGCAACATTGTTTTCTGCAAGTATGAGAACTATTTGGCCCACAAGCAACACTATTGCTCCGCGCGTAACCAGGATACGGGACTGGATGGGGACTCCAACAAGAATTCGGTGACGCCACCGAATGCCGGCGTCGCGGCTGGCGCCTCTGCAGCAGAAACCACTCCGGTAGCTTATCAGCAGCTCATTTGCGCAGCCTGCGGCATTAAGTACACCTCGCTGGATAATCTGCGTGCGCATCAGAACTACTACTGTCCCAAaggtggcgctgctgctgccgccgctgcagccgctgccgctgccacgcccactgctgAGCCCACGCCAGCACCACAGCTCGTCGTACCCAAGGAGAAGTGTATGAAGTGCAAAACGCACCATGAGCATGGCCAGAATTGTCCAGCGCCTCCAGCCACACCTCAGCTGCCACCCTCCTCCGTCTCCAACAGCGTCAACAAGTGTCCCGTTTGTGGCGTCGTTAGCCCCACCGCAGCCCTGGCCCGCAAGCACATGGAGATGCATGGCACAGTGAAGGCTTTTCGCTGCAGCATCTGTCAGTACAAGGGGAACACGTTGCGCGGCATGCGCACCCACATCCGCACCCATTTCGATAAGAAGACCAGCGATGTCAACGAGGAGCACTACATGACTTGCATCTTCGAGGAGGATGCGGCCGCTGTggcagcggcggctgctgctgctgctgcagctgctgcagttgctgctgcagtgcctCCTCAGGCTTTGGATATGCCAACTGTGGCAGCGGCTCAAGAGCAACTAGACCAGCATCCGGCCCAGCTCTTCAACTGCGATCACTGCAATTACGCCTCTACATACAAGGGCAATGTGCTGCGCCACATGAAACTACTGCATCCGCACGTGGCCATTAGTTCACCCTCCATTTCACCCGAGTCCCGCGAACAGGACGCCAATCCTCATGTCCTCATGCCTGAAGTAGCGCTGGTTAACGGGGAGAGAGAGGCAGCTGCTGTGGCTAGCTTTCACATTAAAACGGAACCTTTGGATCAGCCCGTGGCAACGTTGAGCCTGGTGCATGAGAACAACAACTCACCCATTGGAACACCGCACACGCACATTAAAGCTGAGCCCATGGACGTGGGTGTCGAGGTGCCAGCACCTGTGCTGCCCCCACCAATTGCCAACTCCCCGCTGGGACTCAGCGCCGCGGAGGCAATGAAGAAATACTGCTCCACCTGCGACATATCCTTCAACTATGTAAAGACCTTCCTTGCCCACAAGCAGTTCTACTGCAAGAGCAAGCTGCAGCGACCCGAAGCCAATGATAGCCCCAGTCCCACGGTGGGTGGCATGGCATCGATGCCGCTGCAGTCACCCAgcgagctgctgttgctgcagaaGAACAAGGAGAATCTGCAGGAGGCGGCCATTTGA
Protein Sequence
MRWNAPKQQHQQQQQQKTPKRADGSREKPWGSLRADAVDYSKDLSAHELSEEKQQQQQQQLEDQPEDEQLDQQLSSNSSEQPIETDMEQDLDMETQTAQEASEQKLADNSTTPPRSPTPELVPKLERADTPPSVTATPSPPPTPTPPMVLPKLRLNALLASDPALKPDAKELNLHESRLLGPPSKPEQQQQQPDVEPLLKPTRFMCLPCGIAFSSPSTLEAHQAYYCSHRNKDAEEETPSGDKATPGSGGATNANANSSSSGSSGGTGSEPPNKVSRMGKQYACTQCSYSADKKVSLNRHMRMHQTSPATPSLNSLSSFTANGVVAAAAAAAAAAAAAGALEESSSQQIDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGQLTPKPEAGATGAAAAAAAGAAVAAGKHSPQTRNKTPTPAMVAAAAAAAAAAAAAAASLQVTPPEPFLALPTNPIIIVPCSLIRAARLIPGPLTTSTSGIVNPESTCFTLDNGALKPLATALNINALTGSATPTPTPTPMPSSNQLAMPALEPDRPTAPSNVSSLLEAEAKSSPPESSKRKEASVMRETTPLDLSLRRSPISALLQRQRLVRSAAALLDAEDAAGKDHVESISGGSVTPEQIVCAPSLPSSPSMSPSPKRRALSPRSSGAGSASSMSPPATHLLDNLPPLRSMLPAEFSLSESLLAKTNPELALKLAAAAAAAVAGSSSAELAKLGFGVAPAQNPTSAAAQPANPPNAPQIYVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQDTGLDGDSNKNSVTPPNAGVAAGASAAETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGAAAAAAAAAAAATPTAEPTPAPQLVVPKEKCMKCKTHHEHGQNCPAPPATPQLPPSSVSNSVNKCPVCGVVSPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDAAAVAAAAAAAAAAAAVAAAVPPQALDMPTVAAAQEQLDQHPAQLFNCDHCNYASTYKGNVLRHMKLLHPHVAISSPSISPESREQDANPHVLMPEVALVNGEREAAAVASFHIKTEPLDQPVATLSLVHENNNSPIGTPHTHIKAEPMDVGVEVPAPVLPPPIANSPLGLSAAEAMKKYCSTCDISFNYVKTFLAHKQFYCKSKLQRPEANDSPSPTVGGMASMPLQSPSELLLLQKNKENLQEAAI